Gastroesophageal Reflux Disease and Helicobacter pylori in Children

  • Nicolas KalachEmail author


There is a complex relationship among H. pylori, gastric acid production, and the development of reflux symptoms and disease. Studies that fail to address this complexity will not provide clear information on which to base clinical decisions and still not well understood in adults as well as in children.

The implications of H. pylori infection for the acquisition of GERD are a matter of current controversy. Some studies suggest a causative association between H. pylori infection and GERD, whereas others postulate a protective role for H. pylori infection. On balance and based on the pediatric published data, we consider that H. pylori eradication more likely to provide benefits than harm in children with GERD.

Frequency of GERD and clinical manifestations of H. pylori infection; relationship of H. pylori and erosive reflux disease; relationship of GERD and H. pylori CagA and VacA and other genes’ status; effect of H. pylori and type of gastritis on gastrin, ghrelin, motilin, and GERD; influence of H. pylori eradication on GERD symptoms; and, finally, influence of H. pylori on the development of EoE in children were all summarized in this chapter.


GER H. pylori Child Esophagitis 



Cytotoxin-associated gene A


Duodenal ulcers


Eosinophilic esophagitis


Ear nose throat


Eosinophils per high-power field


Gastroesophageal reflux disease


Gastroesophageal reflux

H. pylori

Helicobacter pylori


Immunoglobulin E


Lower esophageal sphincter pressure


Non-ulcer dyspepsia


Nonerosive reflux disease


Rapid urease test


Recurrent abdominal pain


Reflux esophagitis


Polymerase chain reaction


Proton pump inhibitor

upper GI endoscopy

Upper gastrointestinal endoscopy


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Clinique Pédiatrique St AntoineHôpital St Vincent de Paul, Groupement des Hôpitaux de l’Institut Catholique de Lille (GHICL), Catholic University of LilleLille CedexFrance

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