ICIAR 2017: Image Analysis and Recognition pp 541-550 | Cite as

Retinal Biomarkers of Alzheimer’s Disease: Insights from Transgenic Mouse Models

  • Rui Bernardes
  • Gilberto Silva
  • Samuel Chiquita
  • Pedro Serranho
  • António Francisco Ambrósio
Conference paper
First Online:
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10317)

Abstract

In this paper, we use the retina as a window into the central nervous system and in particular to assess changes in the retinal tissue associated with the Alzheimer’s disease. We imaged the retina of wild-type (WT) and transgenic mouse model (TMM) of Alzheimer’s disease with optical coherence tomography and classify retinas into the WT and TMM groups using support vector machines with the radial basis function kernel. Predictions reached an accuracy over 80% at the age of 4 months and over 90% at the age of 8 months. Texture analysis of computed fundus reference images suggests a more heterogeneous organization of the retina in transgenic mice at the age of 8 months in comparison to controls.

Keywords

Alzheimer’s disease 3xTg mouse model Optical coherence tomography Retina Classification 
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Notes

Acknowledgements

This study was supported by the Neuroscience Mantero Belard Prize 2015 (Santa Casa da Misericórdia)(MB-1049-2015), by The Portuguese Foundation for Science and Technology (PEst-UID/NEU/04539/2013), by FEDER-COMPETE (POCI-01-0145-FEDER-007440) and Centro 2020 Regional Operational Programme (CENTRO-01-0145-FEDER-000008: BrainHealth 2020).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Rui Bernardes
    • 1
    • 2
  • Gilberto Silva
    • 1
  • Samuel Chiquita
    • 1
  • Pedro Serranho
    • 1
    • 2
    • 3
  • António Francisco Ambrósio
    • 1
  1. 1.Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  2. 2.Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), ICNASUniversity of CoimbraCoimbraPortugal
  3. 3.Department of Sciences and TechnologyUniversidade AbertaLisboaPortugal

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