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Motor Circuit Abnormalities During Cerebellar Development

  • Elizabeth P. Lackey
  • Roy V. SillitoeEmail author
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

The cerebellum controls ongoing motor function and motor learning. Therefore, damage to its circuits causes a number of movement disorders such as ataxia, dystonia, and tremor. Cerebellar connectivity in both normal and abnormal states has been intensely studied. As a result, its anatomy, circuitry, and neuronal firing properties are among the best understood in the brain. This knowledge has directly facilitated efforts to uncover the mechanisms that cause motor dysfunction. Here, we discuss several mouse models of cerebellar disease. We focus on how cerebellar development depends on genes and neural activity to assemble circuits for behavior.

Keywords

Cerebellum Circuitry Ataxia Purkinje cell Cerebellar nuclei Inferior olive 

Notes

Acknowledgments

This work was supported by funds from Baylor College of Medicine (BCM) and Texas Children’s Hospital. R.V.S. received support from the National Institutes of Neurological Disorders and Stroke (NINDS) R01NS089664. The BCM IDDRC Neuropathology Sub-Core performed the tissue staining (the BCM IDDRC Neurovisualization Core is supported by U54HD083092). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH). We thank Amanda M. Brown for suggestions and comments on an earlier version of the manuscript.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Pathology & ImmunologyBaylor College of MedicineHoustonUSA
  2. 2.Department of NeuroscienceBaylor College of MedicineHoustonUSA
  3. 3.The Jan and Dan Duncan Neurological Research Institute at Texas Children’s HospitalHoustonUSA
  4. 4.Program in Developmental BiologyBaylor College of MedicineHoustonUSA

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