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Early Purkinje Cell Development and the Origins of Cerebellar Patterning

  • Filippo Casoni
  • Laura Croci
  • Ottavio Cremona
  • Richard HawkesEmail author
  • G. Giacomo ConsalezEmail author
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

This chapter explores the mechanisms that regulate Purkinje cell neurogenesis, revealing the finely timed contribution of many regulatory genes in the control of PC progenitor specification, proliferation, subtype differentiation, migration, and survival from the cerebellar primordium to the end of prenatal embryogenesis, discussing some of the key molecules involved and the ways they combine to generate the complex adult cerebellar architecture.

Keywords

Zebrin Transverse zone Stripe Ventricular zone Ebf2 Reelin 

Notes

Acknowledgments

The authors’ research is funded through grants provided by the Italian Telethon Foundation (to GGC) and by the Italian Ministry of Health (to OC).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Università Vita-Salute San RaffaeleMilanItaly
  2. 2.Division of NeuroscienceSan Raffaele Scientific InstituteMilanItaly
  3. 3.Department of Cell Biology and Anatomy, and Hotchkiss Brain Institute, Cumming School of MedicineUniversity of CalgaryCalgaryCanada

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