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The Embryology and Anatomy of the Cerebellum

  • Maryam Rahimi Balaei
  • Niloufar Ashtari
  • Hugo BergenEmail author
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

The cerebellum is an important structure in the central nervous system that controls and regulates motor and non-motor functions. It is located beneath the occipital lobe and dorsal to the brainstem. Today, we know much about its complex circuitry and physiology. The cerebellum has a well-defined and highly organized structure. The cortex of the cerebellum contains eight neuronal cell types and receives input from a variety of sites within the CNS and processes the information in a uniform manner. The cerebellum projects to a variety of different sites within the CNS to regulate motor function. Although much has been discovered regarding the complex architecture of the cerebellum, there are significant gaps in our understanding of the broader role of the cerebellum in brain function. In this chapter, we will review briefly the embryological development of the cerebellum and provide an overview of the anatomy of the cerebellum.

Keywords

Cerebellum Embryology Anatomy Histology Function 

References

  1. 1.
    Morriss-Kay GM, Wilkie AO. Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies. J Anat. 2005;207:637–53.CrossRefGoogle Scholar
  2. 2.
    Sgaier SK, Millet S, Villanueva MP, Berenshteyn F, Song C, Joyner AL. Morphogenetic and cellular movements that shape the mouse cerebellum: insights from genetic fate mapping. Neuron. 2005;45:27–40.PubMedGoogle Scholar
  3. 3.
    Louvi A, Alexandre P, Métin C, Wurst W, Wassef M. The isthmic neuroepithelium is essential for cerebellar midline fusion. Development. 2003;130:5319–30.CrossRefGoogle Scholar
  4. 4.
    Fink AJ, Englund C, Daza RA, Pham D, Lau C, Nivison M, et al. Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip. J Neurosci. 2006;26:3066–76.CrossRefGoogle Scholar
  5. 5.
    Marzban H, Del Bigio MR, Alizadeh J, Ghavami S, Zachariah RM, Rastegar M. Cellular commitment in the developing cerebellum. Front Cell Neurosci. 2015;8:450.CrossRefGoogle Scholar
  6. 6.
    Ito M. Cerebellar circuitry as a neuronal machine. Prog Neurobiol. 2006;78:272–303.CrossRefGoogle Scholar
  7. 7.
    Haines DE, Dietrichs E. The cerebellum – structure and connections. Handb Clin Neurol. 2012;103:3–36.CrossRefGoogle Scholar
  8. 8.
    Apps R, Garwicz M. Anatomical and physiological foundations of cerebellar information processing. Nat Rev Neurosci. 2005;6:297–311.CrossRefGoogle Scholar
  9. 9.
    Shinoda Y, Sugihara I, Wu HS, Sugiuchi Y. The entire trajectory of single climbing and mossy fibers in the cerebellar nuclei and cortex. Prog Brain Res. 2000;124:173–86.CrossRefGoogle Scholar
  10. 10.
    Uusisaari M, De Schutter E. The mysterious microcircuitry of the cerebellar nuclei. J Physiol. 2011;589:3441–57.CrossRefGoogle Scholar
  11. 11.
    Voogd J, Ruigrok TJH. The human nervous system. 3rd ed. San Diego: Elsevier; 2012.Google Scholar
  12. 12.
    Tatu L, Moulin T, Bogousslavsky J, Duvernoy H. Arterial territories of human brain: brainstem and cerebellum. Neurology. 1996;47:1125–35.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Maryam Rahimi Balaei
    • 1
  • Niloufar Ashtari
    • 1
  • Hugo Bergen
    • 1
    Email author
  1. 1.Department of Human Anatomy and Cell Science, Max Rady College of Medicine,Rady Faculty of Health ScienceUniversity of ManitobaWinnipegCanada

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