Inherited Thrombophilias

  • James P. R. BrownEmail author
  • Joanne Douglas


This chapter discusses the clinical presentation and incidence of complications from inherited thrombophilias during pregnancy. The changes in prothrombotic factor levels that occur in normal pregnancy are described as well as the effects of inherited thrombophilias on pregnancy. General principles of management are discussed, including testing and diagnosis, anesthetic options for labor and delivery, and postpartum care.


Thrombophilia Factor V Leiden Prothrombin gene mutation Antithrombin deficiency Protein C deficiency Protein S deficiency 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.UBC Department of Anesthesiology, Pharmacology and TherapeuticsBC Women’s HospitalVancouverCanada
  2. 2.Department of AnesthesiaBC Women’s HospitalVancouverCanada

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