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Glucose 6 Phosphate Deficiency

  • Jerri Chen
  • Suzanne K. W. MankowitzEmail author
Chapter

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzyme defect with an X-linked recessive inheritance pattern that predisposes to hemolysis in response to certain triggers such as medications, infections, or diet (fava beans). The most important aspect in management of G6PD deficiency in both pregnant and nonpregnant patients is avoidance of triggers. Medications to avoid include antimalarials (dapsone, primaquine), antimycobacterials, antineoplastic agents, methylene blue, and antibiotics such as nitrofurantoin. Common anesthetic agents such as sevoflurane, ketamine, fentanyl, and benzodiazepines have not been reported to cause a hemolytic crisis in G6PD-deficient patients. Most pregnant women with G6PD deficiency can have neuraxial analgesia, and opioids and bupivacaine are safe to use.

Keywords

Glucose-6-phosphate dehydrogenase G6PD Hemolysis Hemolytic anemia Jaundice Pregnancy Anesthesia 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of AnesthesiologyColumbia University Medical CenterNew YorkUSA

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