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Factor XI Deficiency

  • James P. R. BrownEmail author
  • Joanne Douglas
Chapter

Abstract

This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of factor XI deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor XI deficiency, including treatment of acute hemorrhage.

Keywords

Factor XI deficiency Hemophilia C Inherited bleeding disorder Inherited coagulopathy 

References

  1. 1.
    Pike G, Bolton-Maggs P. Factor deficiencies in pregnancy. Hematol Oncol Clin N Am. 2011;25:359–78.CrossRefGoogle Scholar
  2. 2.
    Peyvandi F, Garagiola I, Menegatti M. Gynecological and obstetrical manifestations of inherited bleeding disorders in women. J Thromb Haemost. 2011;9:236–45.CrossRefGoogle Scholar
  3. 3.
    Katz D, Beilin Y. Disorders of coagulation in pregnancy. Br J Anaesth. 2015;115:ii75–88.CrossRefGoogle Scholar
  4. 4.
    Silver R, Major H. Maternal coagulation disorders and postpartum hemorrhage. Clin Obstet Gynecol. 2010;53:252–64.CrossRefGoogle Scholar
  5. 5.
    Bolton-Maggs P. Bleeding problems in factor XI deficient women. Haemophilia. 1999;5:155–9.CrossRefGoogle Scholar
  6. 6.
    David A, Paterson-Brown S, Letsky E. Factor XI deficiency presenting in pregnancy: diagnosis and management. Br J Obstet Gynecol. 2002;109:840–3.CrossRefGoogle Scholar
  7. 7.
    Kadir R, Lee C, Sabin C, Pollard D, Economides D. Pregnancy in women with von Willebrand’s disease or factor XI deficiency. Br J Obstet Gynecol. 1998;105:314–21.CrossRefGoogle Scholar
  8. 8.
    Reuveni A, Orbach-Zinger S, Eidelman L, Ginosar Y, Ioscovich A. Peripartum anesthetic management of patients with Factor XI deficiency. J Perinat Med. 2014;42:295–300.CrossRefGoogle Scholar
  9. 9.
    Chi C, Kulkarni A, Lee C, Kadir R. The obstetric experience of women with factor XI deficiency. Acta Obstet Gynecol. 2009;88:1095–100.CrossRefGoogle Scholar
  10. 10.
    Myers B, Pavord S, Kean L, Hill M, Dolan G. Pregnancy outcomes in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency. Br J Obstet Gynecol. 2007;114:643–6.CrossRefGoogle Scholar
  11. 11.
    Singh A, Harnett M, Connors J, Camann W. Factor XI deficiency and obstetrical anesthesia. Anesth Analg. 2009;108:1882–5.CrossRefGoogle Scholar
  12. 12.
    Setty S, Reddell A, England A, Gomez K, Kadir R. The role of recombinant factor VIIa for obstetric block in women with severe factor XI deficiency. Haemophilia. 2011;17:906–9.CrossRefGoogle Scholar
  13. 13.
    Connelly N, Brull S. Anesthetic management of a patient with Factor XI deficiency and Factor XI inhibitor undergoing a cesarean section. Anesth Analg. 1993;76:1365.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.UBC Department of Anesthesiology, Pharmacology and TherapeuticsBC Women’s HospitalVancouverCanada
  2. 2.Department of AnesthesiaBC Women’s HospitalVancouverCanada

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