Factor VII Deficiency

  • James P. R. BrownEmail author
  • Joanne Douglas


This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of factor VII deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor VII deficiency, including treatment of acute hemorrhage.


Factor VII deficiency Inherited bleeding disorder Inherited coagulopathy 


  1. 1.
    Mumford A, Ackroyd S, Alikhan R, Bowles L, Chowdary P, Grainger J, et al. Guideline for the diagnosis and management of the rare coagulation disorders. A United Kingdom Haemophilia Centre Doctors’ Organization guideline on behalf of the British Committee for Standards in Haematology. Br J Haematol. 2014;167:304–26.CrossRefGoogle Scholar
  2. 2.
    Pike G, Bolton-Maggs P. Factor deficiencies in pregnancy. Hematol Oncol Clin N Am. 2011;25:359–78.CrossRefGoogle Scholar
  3. 3.
    Baumann Kreuziger L, Morton C, Reding M. Is prophylaxis required for delivery in women with factor VII deficiency? Haemophilia. 2013;19:827–32.CrossRefGoogle Scholar
  4. 4.
    Matei A, Dolan S, Andrews J, Rivard G. Management of labour and delivery in a patient with acquired factor VII deficiency with inhibitor: a case report. J Obster Gynaecol Can. 2016;38:160–3.CrossRefGoogle Scholar
  5. 5.
    Chi C, Lee C, England A, Hingorani J, Paintsil J, Kadir R. Obstetric analgesia and anaesthesia in women with inherited bleeding disorders. Thromb Haemost. 2009;101:1104–11.CrossRefGoogle Scholar
  6. 6.
    Kulkarni A, Lee C, Kadir R. Pregnancy in women with congenital factor VII deficiency. Haemophilia. 2006;12:413–6.CrossRefGoogle Scholar
  7. 7.
    Peyvandi F, Garagiola I, Menegatti M. Gynecological and obstetrical manifestations of inherited bleeding disorders in women. J Thromb Haemost. 2011;9:236–45.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.UBC Department of Anesthesiology, Pharmacology and TherapeuticsBC Women’s HospitalVancouverCanada
  2. 2.Department of AnesthesiaBC Women’s HospitalVancouverCanada

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