• Emily E. SharpeEmail author


Pheochromocytomas are catecholamine-secreting tumors that can lead to paroxysmal hypertension. These tumors are rare in pregnancy, but early diagnosis is important for improved maternal and fetal outcomes. Multidisciplinary management is essential and timing of resection depends on the gestational age at diagnosis. Primary goals include avoidance of a hypertensive crisis during delivery and definitive surgical resection. Cesarean delivery is the preferred mode in patients with an unresected pheochromocytoma and can be accomplished safely with general anesthesia, epidural anesthesia, or combined epidural-general anesthesia. The neonate and patient should be monitored closely in the postoperative period.


Pheochromocytoma Pregnancy Hypertension Adrenal gland neoplasm Preeclampsia Anesthesia Catecholamines Paraganglioma 



Multiple endocrine neoplasia


Magnetic resonance imaging


  1. 1.
    Kamoun M, Mnif MF, Charfi N, Kacem FH, Naceur BB, Mnif F, et al. Adrenal diseases during pregnancy: pathophysiology, diagnosis and management strategies. Am J Med Sci. 2014;347(1):64–73.CrossRefGoogle Scholar
  2. 2.
    Chen H, Sippel RS, O'Dorisio MS, Vinik AI, Lloyd RV, Pacak K. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas. 2010;39(6):775–83.CrossRefGoogle Scholar
  3. 3.
    Harper MA, Murnaghan GA, Kennedy L, Hadden DR, Atkinson AB. Phaeochromocytoma in pregnancy. Five cases and a review of the literature. Br J Obstet Gynaecol. 1989;96(5):594–606.CrossRefGoogle Scholar
  4. 4.
    Oliva R, Angelos P, Kaplan E, Bakris G. Pheochromocytoma in pregnancy: a case series and review. Hypertension. 2010;55(3):600–6.CrossRefGoogle Scholar
  5. 5.
    Prete A, Paragliola RM, Salvatori R, Corsello SM. Management of catecholamine-secreting tumors in pregnancy: a review. Endocr Pract. 2016;22(3):357–70.CrossRefGoogle Scholar
  6. 6.
    Schenker JG, Chowers I. Pheochromocytoma and pregnancy. Review of 89 cases. Obstet Gynecol Surv. 1971;26(11):739–47.CrossRefGoogle Scholar
  7. 7.
    Kinney MA, Narr BJ, Warner MA. Perioperative management of pheochromocytoma. J Cardiothorac Vasc Anesth. 2002;16(3):359–69.CrossRefGoogle Scholar
  8. 8.
    Johnson RL, Arendt KW, Rose CH, Kinney MA. Refractory hypotension during spinal anesthesia for cesarean delivery due to undiagnosed pheochromocytoma. J Clin Anesth. 2013;25(8):672–4.CrossRefGoogle Scholar
  9. 9.
    James MF. The use of magnesium sulfate in the anesthetic management of pheochromocytoma. Anesthesiology. 1985;62(2):188–90.CrossRefGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Anesthesiology and Perioperative MedicineMayo Clinic College of MedicineRochesterUSA

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