Assessment of Haemodynamic Remodeling in Fetal Aortic Coarctation Using a Lumped Model of the Circulation

  • Paula Giménez MínguezEmail author
  • Bart Bijnens
  • Gabriel Bernardino
  • Èric Lluch
  • Iris Soveral
  • Olga Gómez
  • Patricia Garcia-Canadilla
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10263)


Introduction: Aortic coarctation is one of the most difficult cardiac defects to diagnose before birth, and it accounts for 8% of congenital heart diseases. Antenatal diagnosis is crucial for early treatment of the neonate and to decrease the risk of morbidity and mortality; however the fetal hemodynamic changes are not fully understood and current imaging methods are limited to accurately diagnosis this congenital defect. Objective: We propose to use a lumped model of the fetal circulation to provide insights into the hemodynamic changes in fetuses with aortic coarctation, and thus helping to improve its diagnosis. Methods: To achieve this goal a patient-specific lumped model of the fetal circulation was implemented in OpenCOR, including the modeling of different types and degrees of aortic coarctation. A parametric study of degree and type of coarctation was performed, where blood flow distribution, cerebroplacental ratio, pressure drop over the coarctation and left ventricular pressure were quantified. Results: Obvious changes in the fetal hemodynamics were observed only from 80% of coarctation, corresponding to the clinically used cut-off for pressure drop of 20 mmHg. Furthermore, the observed hemodynamic changes were different depending on the location and degree of the coarctation.


Fetal circulation Modeling Aortic coarctation 



This study was partially supported by the Spanish Ministry of Economy and Competitiveness (grant TIN2014-52923-R; Maria de Maeztu Units of Excellence Programme - MDM-2015-0502), FEDER and the European Union Horizon 2020 Programme for Research and Innovation, under grant agreement No. 642676 (CardioFunXion).


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Paula Giménez Mínguez
    • 1
    Email author
  • Bart Bijnens
    • 1
  • Gabriel Bernardino
    • 1
  • Èric Lluch
    • 2
  • Iris Soveral
    • 3
  • Olga Gómez
    • 3
  • Patricia Garcia-Canadilla
    • 1
  1. 1.Univesitat Pompeu FabraBarcelonaSpain
  2. 2.Philips Research MedisysSuresnesFrance
  3. 3.Fetal i+D Fetal Medical Research CenterBarcelonaSpain

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