Metal Allergy pp 495-506 | Cite as

Metal Allergy in Children

  • Chandler Rundle
  • Nikoleta Brankov
  • Sharon E. JacobEmail author


Metals are significant provocateurs of allergic contact dermatitis in children. Skin barrier defects due to filaggrin gene mutations confer an increased risk of expression of atopic dermatitis, a potential for increased absorption of metals across a defective barrier, and a risk for contact sensitization to metals, particularly nickel. This chapter discusses the complex interplay of environmental and intrinsic factors with respect to metal contact sensitization in children.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Chandler Rundle
    • 1
  • Nikoleta Brankov
    • 2
  • Sharon E. Jacob
    • 3
    Email author
  1. 1.School of MedicineLoma Linda UniversityLoma LindaUSA
  2. 2.Department of DermatologyEastern Virginia Medical SchoolNorfolkUSA
  3. 3.Department of DermatologyLoma LindaUSA

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