Tricuspid Regurgitation in Patients with Heart Transplant

  • Kadir CaliskanEmail author
  • Mihai Strachinaru
  • Osama I. Soliman


In this chapter, an overview of the epidemiology, the pathophysiology, the clinical features, management and prognosis of tricuspid regurgitation in patients post heart transplant will be discussed. An overview of the natural history of severe tricuspid regurgitation and treatment options will be illustrated via a clinical case.


Tricuspid Regurgitation Heart transplant Echocardiography Therapy Outcome 

Supplementary material

Video S1

(MP4 140 kb)

Video S2

(MP4 139 kb)

Video S3

(MP4 0.98 MB)

Video S4

(MP4 301 kb)

Video S5

(MP4 471 kb)

Video S6

(MP4 274 kb)


  1. 1.
    Wong RC, Abrahams Z, Hanna M, Pangrace J, Gonzalez-Stawinski G, Starling R, et al. Tricuspid regurgitation after cardiac transplantation: an old problem revisited. J Heart Lung Transplant. 2008;27(3):247–52.CrossRefPubMedGoogle Scholar
  2. 2.
    Chan MC, Giannetti N, Kato T, Kornbluth M, Oyer P, Valantine HA, et al. Severe tricuspid regurgitation after heart transplantation. J Heart Lung Transplant. 2001;20(7):709–17.CrossRefPubMedGoogle Scholar
  3. 3.
    Berger Y, Har Zahav Y, Kassif Y, Kogan A, Kuperstein R, Freimark D, et al. Tricuspid valve regurgitation after orthotopic heart transplantation: prevalence and etiology. J Transp Secur. 2012;120702:2012.Google Scholar
  4. 4.
    Birnbaum J, Ulrich SM, Schramm R, Hagl C, Lehner A, Fischer M, et al. Transient severe tricuspid regurgitation after transplantation of an extremely oversized donor heart in a child-does size matter? A case report. Pediatr Transplant. 2017;21(1)Google Scholar
  5. 5.
    Cooper LT, Baughman KL, Feldman AM, Frustaci A, Jessup M, Kuhl U, et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation. 2007;116(19):2216–33.CrossRefPubMedGoogle Scholar
  6. 6.
    Fiorelli AI, Coelho GH, Aiello VD, Benvenuti LA, Palazzo JF, Santos Junior VP, et al. Tricuspid valve injury after heart transplantation due to endomyocardial biopsy: an analysis of 3550 biopsies. Transplant Proc. 2012;44(8):2479–82.CrossRefPubMedGoogle Scholar
  7. 7.
    Alharethi R, Bader F, Kfoury AG, Hammond ME, Karwande SV, Gilbert EM, et al. Tricuspid valve replacement after cardiac transplantation. J Heart Lung Transplant. 2006;25(1):48–52.CrossRefPubMedGoogle Scholar
  8. 8.
    Aziz TM, Burgess MI, Rahman AN, Campbell CS, Deiraniya AK, Yonan NA. Risk factors for tricuspid valve regurgitation after orthotopic heart transplantation. Ann Thorac Surg. 1999;68(4):1247–51.CrossRefPubMedGoogle Scholar
  9. 9.
    Wartig M, Tesan S, Gabel J, Jeppsson A, Selimovic N, Holmberg E, et al. Tricuspid regurgitation influences outcome after heart transplantation. J Heart Lung Transplant. 2014;33(8):829–35.CrossRefPubMedGoogle Scholar
  10. 10.
    Filsoufi F, Salzberg SP, Anderson CA, Couper GS, Cohn LH, Adams DH. Optimal surgical management of severe tricuspid regurgitation in cardiac transplant patients. J Heart Lung Transplant. 2006;25(3):289–93.CrossRefPubMedGoogle Scholar
  11. 11.
    Bollano E, Karason K, Liden H, Dellgren G. How should we manage early tricuspid valve regurgitation after heart transplantation? Int J Cardiol. 2016;214:191–3.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Kadir Caliskan
    • 1
    Email author
  • Mihai Strachinaru
    • 1
  • Osama I. Soliman
    • 1
  1. 1.Department of Cardiology, Unit Heart Failure, Heart Transplantation & Mechanical Circulatory SupportThe Thoraxcenter, Erasmus MC: University Medical Center RotterdamRotterdamThe Netherlands

Personalised recommendations