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Combining Anatomy, Measurements and Manipulation of Neuronal Activity to Interrogate Circuit Function in Drosophila

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Decoding Neural Circuit Structure and Function

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Abstract

In this chapter we will discuss the application of genetics to the interrogation of neuronal function in fruit flies from a historical and modern perspective. We will review the current state-of-the-art tool kit for circuit dissection including neuronal measurements, manipulation and quantitative behavioral assessment. We will then discuss how these approaches can be productively applied to the interrogation of circuit computation by discussing recent discoveries in visual circuitry. Due to dramatic progress in recent years, these new tools have greatly expanded our understanding of the cell types and algorithmic transformations that underpin the detection of visual motion.

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Authors and Affiliations

  1. Department of Neurobiology, Harvard Medical School, Boston, USA

    Yvette E. Fisher

  2. Department of Neurobiology, Stanford University, Stanford, USA

    Thomas R. Clandinin

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Correspondence to Thomas R. Clandinin .

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Editors and Affiliations

  1. Department of Molecular Biology and Genetics, Boğaziçi University, Bebek, Istanbul, Turkey

    Arzu Çelik

  2. Fachbereich Biologie, Chemie, Pharmazie, Institut für Biologie—Neurobiologie, Freie Universität Berlin, Berlin, Germany

    Mathias F. Wernet

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Fisher, Y.E., Clandinin, T.R. (2017). Combining Anatomy, Measurements and Manipulation of Neuronal Activity to Interrogate Circuit Function in Drosophila . In: Çelik, A., Wernet, M. (eds) Decoding Neural Circuit Structure and Function. Springer, Cham. https://doi.org/10.1007/978-3-319-57363-2_15

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