Clinical Aspects of Alzheimer’s Disease

  • Fiona KumforEmail author
  • Glenda M. Halliday
  • Olivier Piguet
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 15)


Alzheimer’s disease is the most common form of dementia accounting for 50–60% of all dementia cases. This chapter briefly reviews the history of Alzheimer’s disease and provides an overview of the clinical syndromes associated with Alzheimer pathology and their associated neuroimaging findings. This chapter also reviews the neuropathology and genetics of Alzheimer’s disease and concludes by discussing current work undertaken to identify suitable in vivo biomarkers for the disease.


Biomarkers Cognition Genes Logopenic progressive aphasia Memory Neuroimaging Posterior cortical atrophy 



ATP-binding cassette, subfamily A, member 7


Alzheimer’s disease




Amyloid precursor protein


Bridging integrator 1


Complement component receptor 1


Cerebrospinal fluid


Computer tomography


18F fluorodeoxyglucose positron emission tomography


Major histocompatibility complex class II


Logopenic progressive aphasia


Mild cognitive impairment


Magnetic resonance imaging


Posterior cortical atrophy


11C-labelled Pittsburgh compound B


Presenilin 1


Presenilin 2


Single photon emission computed tomography



This work was supported by funding to Forefront, a collaborative research group dedicated to the study of frontotemporal dementia and motor neurone disease, from the National Health and Medical Research Council (NHMRC) of Australia program grant (#1037746) and the Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Node (#CE110001021) and other grants/sources that are applicable. We thank Heidi Cartwright for the artwork. FK is supported by an Alzheimer’s Australia Dementia Research Foundation Postdoctoral Fellowship and an NHMRC-ARC Dementia Research Development Fellowship (APP1097026). GMH is an NHMRC Senior Principal Research Fellow (APP1079679). OP is an NHMRC Senior Research Fellow (APP1103258).

Conflict of Interest

The authors have no conflict of interest.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Fiona Kumfor
    • 1
    Email author
  • Glenda M. Halliday
    • 1
  • Olivier Piguet
    • 1
  1. 1.School of Psychology, Central Medical School and Brain & Mind CentreUniversity of SydneySydneyAustralia

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