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Pathophysiology of Carpal Tunnel Syndrome

  • Scott F. M. DuncanEmail author
  • Oam Bhate
  • Hatim Mustaly
Chapter

Abstract

This chapter discusses the pathophysiological mechanisms and contributing factors underlying the etiology of carpal tunnel syndrome. The etiology of carpal tunnel syndrome is complex and still has not been fully elucidated. Many factors have been implicated in the development and progression of carpal tunnel syndrome. Injury due to repetitive mechanical stress and resulting nerve injury has been historically thought to be the cause of carpal tunnel syndrome. Additionally, systemic disease states including diabetes, acromegaly, thyroid dysfunction, and rheumatoid arthritis among others have been linked to carpal tunnel syndrome. Age, gender, and genetic factors have also been associated with the development of carpal tunnel syndrome. The various elements that may predispose to carpal tunnel syndrome have been explored in depth in this chapter.

Keywords

Nerve tethering Blood-nerve barrier Obesity Diabetes Thyroid Acromegaly Rheumatoid arthritis 

Abbreviations

BMI

Body mass index

CTS

Carpal tunnel syndrome

IGF-1

Insulin-like growth factor 1

IL-6

Interleukin 6

mRNA

Messenger ribonucleic acid

NCS

Nerve conduction studies

PGE2

Prostaglandin E2

TMNST

Tethered median nerve stress test

VEGF

Vascular endothelial growth factor

VGSC

Voltage-gated sodium channel

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Scott F. M. Duncan
    • 1
    Email author
  • Oam Bhate
    • 2
  • Hatim Mustaly
    • 2
  1. 1.Department of Orthopedic SurgeryBoston University/Boston Medical CenterBostonUSA
  2. 2.Boston University School of MedicineBostonUSA

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