Higher Complex Carbohydrate Diets in Gestational Diabetes

Chapter
Part of the Nutrition and Health book series (NH)

Abstract

Nutrition therapy is the single treatment component that will reach every woman with GDM independent of diagnostic criteria. Despite the adaptive insulin resistance of pregnancy, an optimal mixture of higher quality complex carbohydrates with less glycemic potential, lower fat, and appropriate protein in the context of higher overall diet quality holds potential for promotion of good glycemic health while meeting pregnancy nutritional goals. The preponderance of evidence from randomized trials in GDM to date suggests that a balanced liberalization of higher quality complex carbohydrates results in good glycemic control, improved insulin action and improved maternal glucose tolerance, improved lipemia, and vascular benefits, while low-GI diets in particular may reduce the need for insulin, and lower postprandial glycemia. Identifying a diet for GDM that can alter maternal/fetal metabolism in late pregnancy when fetal growth accelerates are critical to reducing short- and long-term metabolic risk in this growing cohort of mothers and infants. Nutrition therapy in GDM holds great potential to effectively treat this population by optimizing the intrauterine environment.

Keywords

Gestational diabetes Diet Nutrition Glycemic index Complex carbohydrates Diet quality Glucose Insulin resistance Glycemia 

Abbreviations

AUC

Area-under-the-curve

BMI

Body mass index

DASH

Dietary approaches to stop hypertension diet

FFA

Free fatty acids

GDM

Gestational diabetes mellitus

GI

Glycemic index

GL

Glycemic load

LGA

Large-for-gestational-age

RCT

Randomized clinical trial

TG

Triglycerides

References

  1. 1.
    Sacks DA, Hadden DR, Maresh M, Deerochanawong C, Dyer AR, Metzger BE, et al. Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Diabetes Care. 2012;35(3):526–8.PubMedPubMedCentralCrossRefGoogle Scholar
  2. 2.
    Hernandez TL, Anderson MA, Chartier-Logan C, Friedman JE, Barbour LA. Strategies in the nutritional management of gestational diabetes. Clin Obstet Gynecol. 2013;56(4):803–15.PubMedPubMedCentralCrossRefGoogle Scholar
  3. 3.
    Barker DJ, Thornburg KL. The obstetric origins of health for a lifetime. Clin Obstet Gynecol. 2013;56(3):511–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Mestman JH. Historical notes on diabetes and pregnancy. Endocrinol. 2002;12:224–42.CrossRefGoogle Scholar
  5. 5.
    Jovanovic-Peterson L, Peterson CM. Dietary manipulation as a primary treatment strategy for pregnancies complicated by diabetes. J Am Coll Nutr. 1990;9(4):320–5.PubMedCrossRefGoogle Scholar
  6. 6.
    Hernandez TL. Nutrition therapy in gestational diabetes: the case for complex carbohydrates. Diabetes Spectr. 2016;29(2):82–8.PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    Westman EC, Yancy WS Jr, Humphreys M. Dietary treatment of diabetes mellitus in the pre-insulin era (1914–1922). Perspect Biol Med. 2006;49(1):77–83.PubMedCrossRefGoogle Scholar
  8. 8.
    Metzger BE, Buchanan TA, Coustan D, de Leiva A, Dunger DB, Hadden DR, et al. Summary and recommendations of the fifth international workshop-conference on Gestational Diabetes Mellitus. Diabetes Care. 2007;30(Suppl 2):S251–60.PubMedCrossRefGoogle Scholar
  9. 9.
    Han S, Crowther CA, Middleton P, Heatley E. Different types of dietary advice for women with gestational diabetes mellitus. Cochrane Database Syst Rev. 2013;3:CD009275.Google Scholar
  10. 10.
    Barrett HL, Dekker NM, McIntyre HD, Callaway LK. Normalizing metabolism in diabetic pregnancy: is it time to target lipids? Diabetes Care. 2014;37(5):1484–93.PubMedCrossRefGoogle Scholar
  11. 11.
    Schaefer-Graf UM, Graf K, Kulbacka I, Kjos SL, Dudenhausen J, Vetter K, et al. Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus. Diabetes Care. 2008;31(9):1858–63.PubMedPubMedCentralCrossRefGoogle Scholar
  12. 12.
    Wolever TM. Is glycaemic index (GI) a valid measure of carbohydrate quality? Eur J Clin Nutr. 2013;67(5):522–31.PubMedCrossRefGoogle Scholar
  13. 13.
    Augustin LS, Kendall CW, Jenkins DJ, Willett WC, Astrup A, Barclay AW, et al. Glycemic index, glycemic load and glycemic response: an International Scientific Consensus Summit from the International Carbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis. 2015;25(9):795–815.PubMedCrossRefGoogle Scholar
  14. 14.
    U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015–2020 Dietary guidelines for Americans. 2015. Report No.: 8th ed.Google Scholar
  15. 15.
    Small P, Brand-Miller JC. From complex carbohydrate to glycemic index: tracing the controversy. Nutr Today. 2009;44(6):236–43.CrossRefGoogle Scholar
  16. 16.
    Freinkel N. Banting lecture 1980. Of pregnancy and progeny. Diabetes. 1980;29(12):1023–35.PubMedCrossRefGoogle Scholar
  17. 17.
    Di Cianni G, Miccoli R, Volpe L, Lencioni C, Del Prato S. Intermediate metabolism in normal pregnancy and in gestational diabetes. Diabetes Metab Res Rev. 2003;19(4):259–70.PubMedCrossRefGoogle Scholar
  18. 18.
    Buchanan TA, Xiang A, Kjos SL, Watanabe RM. What is gestational diabetes. Diabetes Care. 2007;30(Suppl 2):S105–11.PubMedCrossRefGoogle Scholar
  19. 19.
    Butte NF. Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr. 2000;71(5 Suppl):1256S–61S.PubMedGoogle Scholar
  20. 20.
    Sivan E, Chen X, Homko CJ, Reece EA, Boden G. Longitudinal study of carbohydrate metabolism in healthy obese pregnant women. Diabetes Care. 1997;20(9):1470–5.PubMedCrossRefGoogle Scholar
  21. 21.
    Sivan E, Homko CJ, Whittaker PG, Reece EA, Chen X, Boden G. Free fatty acids and insulin resistance during pregnancy. J Clin Endocrinol Metab. 1998;83(7):2338–42.PubMedGoogle Scholar
  22. 22.
    Metzger BE. Long-term outcomes in mothers diagnosed with gestational diabetes mellitus and their offspring. Clin Obstet Gynecol. 2007;50(4):972–9.PubMedCrossRefGoogle Scholar
  23. 23.
    Lauenborg J, Hansen T, Jensen DM, Vestergaard H, Molsted-Pedersen L, Hornnes P, et al. Increasing incidence of diabetes after gestational diabetes: a long-term follow-up in a Danish population. Diabetes Care. 2004;27(5):1194–9.PubMedCrossRefGoogle Scholar
  24. 24.
    Rogers I. The influence of birthweight and intrauterine environment on adiposity and fat distribution in later life. Int J Obes Relat Metab Disord. 2003;27(7):755–77.PubMedCrossRefGoogle Scholar
  25. 25.
    Vohr BR, McGarvey ST, Tucker R. Effects of maternal gestational diabetes on offspring adiposity at 4-7 years of age. Diabetes Care. 1999;22(8):1284–91.PubMedCrossRefGoogle Scholar
  26. 26.
    Catalano PM, Thomas A, Huston-Presley L, Amini SB. Increased fetal adiposity: a very sensitive marker of abnormal in utero development. Am J Obstet Gynecol. 2003;189(6):1698–704.PubMedCrossRefGoogle Scholar
  27. 27.
    Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism. Diabetes Care. 1995;18(5):611–7.PubMedCrossRefGoogle Scholar
  28. 28.
    Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290–6.PubMedCrossRefGoogle Scholar
  29. 29.
    Dabelea D, Mayer-Davis EJ, Lamichhane AP, D’Agostino RB Jr, Liese AD, Vehik KS, et al. Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH Case-Control Study. Diabetes Care. 2008;31(7):1422–6.PubMedPubMedCentralCrossRefGoogle Scholar
  30. 30.
    Wells JC, Chomtho S, Fewtrell MS. Programming of body composition by early growth and nutrition. Proc Nutr Soc. 2007;66(3):423–34.PubMedCrossRefGoogle Scholar
  31. 31.
    Ahlsson F, Gustafsson J, Tuvemo T, Lundgren M. Females born large for gestational age have a doubled risk of giving birth to large for gestational age infants. Acta Paediatr. 2007;96(3):358–62.PubMedCrossRefGoogle Scholar
  32. 32.
    Barbour LA. Changing perspectives in pre-existing diabetes and obesity in pregnancy: maternal and infant short- and long-term outcomes. Curr Opin Endocrinol Diabetes Obes. 2014;21(4):257–63.PubMedCrossRefGoogle Scholar
  33. 33.
    Friedman JE. Obesity and gestational diabetes mellitus pathways for programming in mouse, monkey, and man-where do we go next? The 2014 Norbert Freinkel Award Lecture. Diabetes Care. 2015 Aug;38(8):1402–11.Google Scholar
  34. 34.
    Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011;478(7367):110–3.PubMedPubMedCentralCrossRefGoogle Scholar
  35. 35.
    Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, et al. Dynamics of fat cell turnover in humans. Nature. 2008;453(7196):783–7.PubMedCrossRefGoogle Scholar
  36. 36.
    Lawson EJ, Rajaram S. A transformed pregnancy: the psychosocial consequences of gestational diabetes. Sociol Health Illn. 1994;16(4):536–62.CrossRefGoogle Scholar
  37. 37.
    Hui AL, Sevenhuysen G, Harvey D, Salamon E. Stress and anxiety in women with gestational diabetes during dietary management. Diabetes Educ. 2014;40(5):668–77.PubMedCrossRefGoogle Scholar
  38. 38.
    Smith-Morris CM. Diagnostic controversy: gestational diabetes and the meaning of risk for pima Indian women. Med Anthropol. 2005;24(2):145–77.PubMedCrossRefGoogle Scholar
  39. 39.
    Hui AL, Sevenhuysen G, Harvey D, Salamon E. Food choice decision-making by women with gestational diabetes. Can J Diabetes. 2014;38(1):26–31.PubMedCrossRefGoogle Scholar
  40. 40.
    Teixeira PJ, Carraca EV, Marques MM, Rutter H, Oppert JM, De Bourdeaudhuij I, et al. Successful behavior change in obesity interventions in adults: a systematic review of self-regulation mediators. BMC Med. 2015;13:84.Google Scholar
  41. 41.
    Institute of Medicine, National Research Council. Weight gain during pregnancy: Reexamining the guidelines. Committee to reexamine IOM pregnancy weight gain guidelines. National Academies Press, Washington, D.C.: Institute of Medicine and National Research Council of the National Academies; 2009.Google Scholar
  42. 42.
    Magee MS, Knopp RH, Benedetti TJ. Metabolic effects of 1200-kcal diet in obese pregnant women with gestational diabetes. Diabetes. 1990;39(2):234–40.PubMedCrossRefGoogle Scholar
  43. 43.
    Frayn K. Metabolic regulation: a human perspective. 2nd ed. Oxford, UK: Blackwell Science; 2003.Google Scholar
  44. 44.
    Holme AM, Roland MC, Lorentzen B, Michelsen TM, Henriksen T. Placental glucose transfer: a human in vivo study. PLoS ONE. 2015;10(2):e0117084.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Simpson SJ, Raubenheimer D. Obesity: the protein leverage hypothesis. Obes Rev. 2005;6(2):133–42.PubMedCrossRefGoogle Scholar
  46. 46.
    Hernandez TL, Sutherland JP, Wolfe P, Allian-Sauer M, Capell WH, Talley ND, et al. Lack of suppression of circulating free fatty acids and hypercholesterolemia during weight loss on a high-fat, low-carbohydrate diet. Am J Clin Nutr. 2010;91(3):578–85.PubMedPubMedCentralCrossRefGoogle Scholar
  47. 47.
    Gropper SS, Smith JL, Groff JL. Advanced nutrition and human metabolism. 4th ed. Belmont, CA, USA: Thomson Wadsworth; 2005.Google Scholar
  48. 48.
    Aziz A, Dumais L, Barber J. Health Canada’s evaluation of the use of glycemic index claims on food labels. Am J Clin Nutr. 2013;98(2):269–74.PubMedCrossRefGoogle Scholar
  49. 49.
    Bao J, Atkinson F, Petocz P, Willett WC, Brand-Miller JC. Prediction of postprandial glycemia and insulinemia in lean, young, healthy adults: glycemic load compared with carbohydrate content alone. Am J Clin Nutr. 2011;93(5):984–96.PubMedCrossRefGoogle Scholar
  50. 50.
    Brand-Miller JC, Buyken AE. The glycemic index issue. Curr Opin Lipidol. 2012;23(1):62–7.PubMedCrossRefGoogle Scholar
  51. 51.
    Moses RG, Brand-Miller JC. The use of a low glycaemic index diet in pregnancy: an evolving treatment paradigm. Diabetes Res Clin Pract. 2011;91(1):13–4.PubMedCrossRefGoogle Scholar
  52. 52.
    International Organization for Standardization. Determination of glycaemic index and recommendation for food classification. International Organization for Standardization 2010(ISO 26642:2010). Available from: URL: https://www.iso.org/obp/ui/#iso:std:iso:26642:ed-1:v1:en.
  53. 53.
    Eckel RH. Role of glycemic index in the context of an overall heart-healthy diet. JAMA. 2014;312(23):2508–9.PubMedCrossRefGoogle Scholar
  54. 54.
    Nolan CJ. Improved glucose tolerance in gestational diabetic women on a low fat, high unrefined carbohydrate diet. Aust N Z J Obstet Gynaecol. 1984;24(3):174–7.PubMedCrossRefGoogle Scholar
  55. 55.
    Hu ZG, Tan RS, Jin D, Li W, Zhou XY. A low glycemic index staple diet reduces postprandial glucose values in Asian women with gestational diabetes mellitus. J Investig Med. 2014;62(8):975–9.PubMedCrossRefGoogle Scholar
  56. 56.
    Hernandez TL, van Pelt RE, Anderson MA, Daniels LJ, West NA, Donahoo WT, et al. A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: a randomized crossover study. Diabetes Care. 2014;37(5):1254–62.PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    Hernandez TL, van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, et al. Women With gestational diabetes mellitus randomized to a higher-complex carbohydrate/low-fat diet manifest lower adipose tissue insulin resistance, inflammation, glucose, and free fatty acids: a pilot study. Diabetes Care. 2016;39(1):39–42.PubMedCrossRefGoogle Scholar
  58. 58.
    Louie JC, Markovic TP, Perera N, Foote D, Petocz P, Ross GP, et al. A randomized controlled trial investigating the effects of a low-glycemic index diet on pregnancy outcomes in gestational diabetes mellitus. Diabetes Care. 2011;34(11):2341–6.PubMedPubMedCentralCrossRefGoogle Scholar
  59. 59.
    Reece EA, Hagay Z, Gay LJ, O’Connor T, Degennaro N, Homko CJ, et al. A randomized clinical trial of a fiber-enriched diabetic diet vs. the standard American Diabetes Association-recommended diet in the management of diabetes mellitus in pregnancy. J Matern Fetal Invest. 1995;5:8–12.Google Scholar
  60. 60.
    Cypryk K, Kaminska P, Kosinski M, Pertynska-Marczewska M, Lewinski A. A comparison of the effectiveness, tolerability and safety of high and low carbohydrate diets in women with gestational diabetes. Endokrynol Pol. 2007;58(4):314–9.PubMedGoogle Scholar
  61. 61.
    Moreno-Castilla C, Hernandez M, Bergua M, Alvarez MC, Arce MA, Rodriguez K, et al. Low-carbohydrate diet for the treatment of gestational diabetes: a randomized controlled trial. Diabetes Care. 2013 Apr 5.Google Scholar
  62. 62.
    Asemi Z, Tabassi Z, Samimi M, Fahiminejad T, Esmaillzadeh A. Favourable effects of the dietary approaches to stop hypertension diet on glucose tolerance and lipid profiles in gestational diabetes: a randomised clinical trial. Br J Nutr. 2013;109(11):2024–30.PubMedCrossRefGoogle Scholar
  63. 63.
    Asemi Z, Samimi M, Tabassi Z, Sabihi SS, Esmaillzadeh A. A randomized controlled clinical trial investigating the effect of DASH diet on insulin resistance, inflammation, and oxidative stress in gestational diabetes. Nutrition. 2013;29(4):619–24.PubMedCrossRefGoogle Scholar
  64. 64.
    Asemi Z, Samimi M, Tabassi Z, Esmaillzadeh A. The effect of DASH diet on pregnancy outcomes in gestational diabetes: a randomized controlled clinical trial. Eur J Clin Nutr. 2014;68(4):490–5.PubMedCrossRefGoogle Scholar
  65. 65.
    Hernandez TL. Glycemic targets in pregnancies affected by diabetes: historical perspective and future directions. Curr Diab Rep. 2015;15(1):565.PubMedCrossRefGoogle Scholar
  66. 66.
    McFarland MB, Langer O, Conway DL, Berkus MD. Dietary therapy for gestational diabetes: how long is long enough? Obstet Gynecol. 1999;93(6):978–82.PubMedGoogle Scholar
  67. 67.
    American College of Obstetricians and Gynecologists. ACOG practice bulletin: gestational diabetes, Report number 30; September, 2001. Obstet Gynecol. 2001;98(3):525–38.Google Scholar
  68. 68.
    Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996;97(12):2859–65.PubMedPubMedCentralCrossRefGoogle Scholar
  69. 69.
    Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30(Supplement 2):S1–8.CrossRefGoogle Scholar
  70. 70.
    Major CA, Henry MJ, de Veciana M, Morgan MA. The effects of carbohydrate restriction in patients with diet-controlled gestational diabetes. Obstet Gynecol. 1998;91(4):600–4.PubMedGoogle Scholar
  71. 71.
    Moses RG, Barker M, Winter M, Petocz P, Brand-Miller JC. Can a low-glycemic index diet reduce the need for insulin in gestational diabetes mellitus? A randomized trial. Diabetes Care. 2009;32(6):996–1000.PubMedPubMedCentralCrossRefGoogle Scholar
  72. 72.
    Louie JC, Markovic TP, Ross GP, Foote D, Brand-Miller JC. Effect of a low glycaemic index diet in gestational diabetes mellitus on post-natal outcomes after 3 months of birth: a pilot follow-up study. Matern Child Nutr. 2015;11(3):409–14.PubMedCrossRefGoogle Scholar
  73. 73.
    Pastor-Villaescusa B, Rangel-Huerta OD, Aguilera CM, Gil A. A systematic review of the efficacy of bioactive compounds in cardiovascular disease: carbohydrates, active lipids and nitrogen compounds. Ann Nutr Metab. 2015;66(2–3):168–81.PubMedCrossRefGoogle Scholar
  74. 74.
    Grant SM, Wolever TM, O’Connor DL, Nisenbaum R, Josse RG. Effect of a low glycaemic index diet on blood glucose in women with gestational hyperglycaemia. Diabetes Res Clin Pract. 2011;91(1):15–22.PubMedCrossRefGoogle Scholar
  75. 75.
    Walsh JM, McGowan CA, Mahony R, Foley ME, McAuliffe FM. Low glycaemic index diet in pregnancy to prevent macrosomia (ROLO study): randomised control trial. BMJ. 2012;345:e5605.PubMedPubMedCentralCrossRefGoogle Scholar
  76. 76.
    McGowan CA, Walsh JM, Byrne J, Curran S, McAuliffe FM. The influence of a low glycemic index dietary intervention on maternal dietary intake, glycemic index and gestational weight gain during pregnancy: a randomized controlled trial. Nutr J. 2013;12(1):140.PubMedPubMedCentralCrossRefGoogle Scholar
  77. 77.
    Markovic TP, Muirhead R, Overs S, Ross GP, Louie JC, Kizirian N, et al. randomized controlled trial investigating the effects of a low-glycemic index diet on pregnancy outcomes in women at high risk of gestational diabetes mellitus: the GI baby 3 study. Diabetes Care. 2016;39(1):31–8.PubMedCrossRefGoogle Scholar
  78. 78.
    Kizirian NV, Kong Y, Muirhead R, Brodie S, Garnett SP, Petocz P, et al. Effects of a low-glycemic index diet during pregnancy on offspring growth, body composition, and vascular health: a pilot randomized controlled trial. Am J Clin Nutr. 2016;103(4):1073–82.PubMedCrossRefGoogle Scholar
  79. 79.
    Louie JC, Buyken AE, Brand-Miller JC, Flood VM. The link between dietary glycemic index and nutrient adequacy. Am J Clin Nutr. 2012;95(3):694–702.PubMedCrossRefGoogle Scholar
  80. 80.
    American College of Obstetricians and Gynecologists. ACOG Practice Bulletin: Gestational Diabetes Mellitus. Washington, DC: American College of Obstetricians and Gynecologists; 2013. Report No.: 137.Google Scholar
  81. 81.
    Blumer I, Hadar E, Hadden DR, Jovanovic L, Mestman JH, Murad MH, et al. Diabetes and pregnancy: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2013;98(11):4227–49.PubMedCrossRefGoogle Scholar
  82. 82.
    Evert AB, Boucher JL, Cypress M, Dunbar SA, Franz MJ, Mayer-Davis EJ, et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care. 2013;36(11):3821–42.PubMedPubMedCentralCrossRefGoogle Scholar
  83. 83.
    Eckel RH, Jakicic JM, Ard JD, Hubbard VS, de Jesus JM, Lee IM, et al. 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2013 Nov 12.Google Scholar
  84. 84.
    Food and Agriculture Organization of the United Nations. Carbohydrates in human nutrition. Food and Agriculture Organization of the United Nations 1997 (FAO Food and Nutrition Paper-66). Available from: URL: http://www.fao.org/docrep/W8079E/w8079e00.htm#Contents.
  85. 85.
    Nicklas JM, Barbour LA. Optimizing weight for maternal and infant health—tenable, or too late? Expert Rev Endocrinol Metab. 2015;10(2):227–42.Google Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Medicine, Division of Endocrinology, Metabolism, and DiabetesUniversity of ColoradoAuroraUSA

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