Uropathogenic Escherichia coli: An Ideal Resource for DNA Microarray Probe Designing
Uropathogenic Escherichia coli (UPEC) is the most important bacterial agent causing urinary tract infections (UTIs) in patients around the world. The UTIs rank second among different types of infectious diseases. So, there is an urgent need to have a rapid and accurate diagnostic method for detecting UTIs. DNA microarray is an advanced pan-genomic technique which can be used as a rapid and accurate diagnostic method with high specificity and sensitivity. Designing a collection of DNA microarray probes enables us to have a sharp methodology for detection and identification of UPEC pathotypes. For this reason, the authors of the present review literature have tried to represent a vast range of availabilities regarding UPEC recognition by DNA microarray probe designing.
UPEC encompasses a wide range of virulence genes which are contributed to UTIs. This characteristic makes UPEC an ideal resource for DNA microarray probe designing to have a reliable UTIs diagnostic method.
Besides, UPEC possesses different pathogenic strains which are distributed worldwide. And individual strain has its particular conserved sequences within the virulence genes. In other word, DNA microarray probes can be designed for specific UPEC strains within different geographical regions.
In conclusion, UPEC is a living accessible genomic treasure which can be used for designing a diversity of DNA microarray probes with a high specificity and sensitivity.
KeywordsMicroarray Urinary tract infection Uropathogenic Escherichia coli Probe Pangenome
We are obliged to Shahr-e-Qods Branch, Islamic Azad University as the financial supporter of this paper for presenting in IWBBIO 2017, Granada, Spain.
We also have special thanks to Profs. Ignacio Rojas and Francisco Ortuño for their kind helps and collaborations.
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