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Role of Vitamin D in Rheumatoid Arthritis

  • Mattia BellanEmail author
  • Pier Paolo Sainaghi
  • Mario Pirisi
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 996)

Abstract

Vitamin D is a fat soluble hormone, with a well described role in bone health and calcium/phosphate metabolism. Recent evidences have related vitamin D to other physiological functions and pathological conditions. Specifically, vitamin D has widely proven activities on immune system and evidences suggest that it may be implicated in the pathogenesis of rheumatoid arthritis (RA). The relationship between vitamin D and RA is complex, also because a deficitary vitamin D status, which is very common in RA patients, can contribute to the increased risk of osteoporosis typical of RA. In this chapter, will be described and discussed the main aspects of the relationship between RA and vitamin D.

Keywords

Vitamin D Rheumatoid arthritis Hypovitaminosis D 

List of Abbreviations

1,25(OH)2 vitamin D

1,25-dihydroxyvitamin D

25(OH) vitamin D

25-hydroxyvitamin D

APC

Antigen presenting cells

ARD

Autoimmune rheumatic diseases

BMD

Bone mineral density

BMI

Bone mass index

CD

Cluster of differentiation

C-EBP

CCAAT-enhancer-binding proteins

CRP

C-reactive protein

CTLA-4

Cytotoxic T-Lymphocyte Antigen 4

DC

Dendritic cells

Dkk-1

Dickkopf-related protein 1

EGFR

Epidermal growth factor receptor

Foxp3

Forkhead box P3

HIV

Human immunodeficiency virus

IBD

Inflammatory bowel diseases

IFN-γ

Interferon γ

IL

Interleukin

IU

International units

JAK

Janus kinase

MAPK

Mitogen-activated protein kinase

MHC

Major histocompatibility complex

MS

Multiple sclerosis

NF-kB

nuclear factor kappa-light-chain-enhancer of activated B cells

OPG

Osteoprotegerin

PTH

Parathyroid hormone

RA

Rheumatoid Arthritis

RANK

Receptor activator of nuclear factor kappa-B

RANKL

Receptor activator of nuclear factor kappa-B ligand

RCT

Randomized clinical trial

RXR

Retinoid X receptor

SLE

Systemic lupus erythematosus

STAT1α

Signal transducer and activator of transcription 1

T1DM

Type 1 diabetes mellitus

TGFα

Transforming growth factor α

Th

T helper

TLR

Toll like receptor

TNFα

Tumor necrosis factor α

Treg

Regulatory T cells

UCTD

Undifferentiated connective tissue disease

UV

Ultraviolet

VDR

Vitamin D receptor

VDRE

Vitamin D Responsive Elements

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Mattia Bellan
    • 1
    • 2
    Email author
  • Pier Paolo Sainaghi
    • 2
  • Mario Pirisi
    • 1
    • 2
  1. 1.Department of Translational MedicineUniversità del Piemonte Orientale UPONovaraItaly
  2. 2.Immunorheumatology Unit, Internal Medicine DivisionAOU Maggiore della CaritàNovaraItaly

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