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Adipose Tissue-Derived Stem Cells in Regenerative Medicine and Plastic Surgery: Perspective from Personal Practice

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Pancreas, Kidney and Skin Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

Clinical observations of improvement of soft tissues after lipo-filling led to the hypothesis that adipose tissue is more than a filler. It is known that fat tissue has a complex cellular composition being a rich source of mesenchymal multipotent stem cells. These qualities make fat an important tool both in tissue regeneration and in regenerative plastic surgery (RPS). RPS in our practice is oriented toward reconstruction, correction, and rejuvenation of soft tissues of different anatomic areas, neck, hands, limbs, and abdomen, affected by congenital, oncological, posttraumatic, or aging conditions. Our focus is a closed surgery that has visible regenerative outcomes explained by the synergic action of three main agents combined in a single surgical session, under general anesthesia: autologous microfat graft, fractional CO2 laser (superficial ablative resurfacing), and PRP. Additional optimizing factors can be used as ADSC enrichment of fat and laser-assisted lipolysis. The equipment that we use is based on microcannulas and lasers (fractional CO2 and diode). The result consists in regeneration of normal, pathological skin, underlying soft tissues and improved safety.

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Notes

  1. 1.

    This work was funded by the Romanian Academy. Alina Constantin acknowledges the financial support of the European Social Found within the Sectorial Operational Program Human Resources Development 2007-2013 (ID: POSDRU/159/1.5/S/133391).

Abbreviations

ADSCs:

Adipose-derived stem cells

AFT:

Autologous fat transfer

BM:

Bone marrow

BMSCs:

Bone marrow stem cells

EM:

Electromagnetic

HLLT:

High-level laser treatment

HSCs:

Hematopoietic stem cells

LAL:

Laser-assisted lipolysis

LLLT:

Low-level laser treatment

MSCs:

Mesenchymal stem cells

PRP:

Platelet-rich plasma

PS:

Plastic surgery

RM:

Regenerative medicine

RPS:

Regenerative plastic surgery

SCNs:

Stem cells niches

SVF:

Stromal vascular fraction

TM:

Translational medicine

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Authors and Affiliations

  1. ProEstetica Hospital, Research Center in Regenerative Medicine and Surgery of Romanian Academy of Medical Sciences, 38-40, Tudor Stefan Street, Bucharest, Romania

    Dana Jianu MD, PhD, Oltjon Cobani & Stefan Jianu

Authors
  1. Dana Jianu MD, PhD
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  2. Oltjon Cobani
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  3. Stefan Jianu
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Corresponding author

Correspondence to Dana Jianu MD, PhD .

Editor information

Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam

    Phuc Van Pham

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Jianu, D., Cobani, O., Jianu, S. (2017). Adipose Tissue-Derived Stem Cells in Regenerative Medicine and Plastic Surgery: Perspective from Personal Practice. In: Pham, P. (eds) Pancreas, Kidney and Skin Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-55687-1_12

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