Mitochondrial Dynamics in Cardiovascular Medicine pp 431-450 | Cite as
MitomiRs Keep the Heart Beating
Chapter
First Online:
Abstract
In this chapter, we focus on the microRNAs (miRNAs or miRs) that have been found in the mitochondrial compartment, and target either mitochondrial or nuclear encoded genes present in mitochondria, leading to an alteration of mitochondrial function. We term this subset of miRNAs as “MitomiRs”.
Keywords
Electron Transport Chain Fetal Heart Diabetic Cardiomyopathy Beating Heart Mitochondrial Fission
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Notes
Acknowledgments
This work was supported by a Scientist Development Grant from the American Heart Association 14SDG18890049 (S.D.).
References
- 1.Rottiers V, Naar AM. MicroRNAs in metabolism and metabolic disorders. Nat Rev Mol Cell Biol. 2012;13:239–50.PubMedPubMedCentralCrossRefGoogle Scholar
- 2.Wronska A, Kurkowska-Jastrzebska I, Santulli G. Application of microRNAs in diagnosis and treatment of cardiovascular disease. Acta Physiol (Oxford). 2015;213:60–83.CrossRefGoogle Scholar
- 3.Hulsmans M, Holvoet P. MicroRNAs as early biomarkers in obesity and related metabolic and cardiovascular diseases. Curr Pharm Des. 2013;19:5704–17.PubMedCrossRefGoogle Scholar
- 4.Novak J, Kruzliak P, Bienertova-Vasku J, Slaby O, Novak M. MicroRNA-206: a promising theranostic marker. Theranostics. 2014;4:119–33.PubMedPubMedCentralCrossRefGoogle Scholar
- 5.Sayed D, Rane S, Abdellatif M. MicroRNAs challenge the status quo of therapeutic targeting. J Cardiovasc Transl Res. 2009;2:100–7.PubMedCrossRefGoogle Scholar
- 6.Ambros V. The functions of animal microRNAs. Nature. 2004;431:350–5.PubMedCrossRefGoogle Scholar
- 7.Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–97.PubMedCrossRefGoogle Scholar
- 8.Hwang HW, Wentzel EA, Mendell JT. A hexanucleotide element directs microRNA nuclear import. Science. 2007;315:97–100.PubMedCrossRefGoogle Scholar
- 9.Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 2014;15:509–24.PubMedCrossRefGoogle Scholar
- 10.Bruneau BG. Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol. 2013;5:a008292.PubMedPubMedCentralCrossRefGoogle Scholar
- 11.Lopaschuk GD, Collins-Nakai RL, Itoi T. Developmental changes in energy substrate use by the heart. Cardiovasc Res. 1992;26:1172–80.PubMedCrossRefGoogle Scholar
- 12.Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J. MicroRNAs in the human heart. A clue to fetal gene reprogramming in heart failure. Circulation. 2007;116:258–67.Google Scholar
- 13.Chistiakov DA, Orekhov AN, Bobryshev YV. Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction). J Mol Cell Cardiol. 2016;94:107–21.PubMedCrossRefGoogle Scholar
- 14.Romaine SP, Tomaszewski M, Condorelli G, Samani NJ. MicroRNAs in cardiovascular disease: an introduction for clinicians. Heart. 2015;101:921–8.PubMedPubMedCentralCrossRefGoogle Scholar
- 15.Xin M, Olson EN, Bassel-Duby R. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat Rev Mol Cell Biol. 2013;14:529–41.PubMedPubMedCentralCrossRefGoogle Scholar
- 16.Tirziu D, Giordano FJ, Simons M. Cell communications in the heart. Circulation. 2010;122:928–37.PubMedPubMedCentralCrossRefGoogle Scholar
- 17.Santulli G. MicroRNAs and endothelial (dys)function. J Cell Physiol. 2016;231:1638–44.PubMedCrossRefGoogle Scholar
- 18.Santulli G, Nakashima R, Yuan Q, Marks AR. Intracellular calcium release channels: an update. J Physiol. 2017 (in press). doi: 10.1113/JP272781.
- 19.Marín-García J, Goldenthal MJ. The mitochondrial organelle and the heart. Rev Esp Cardiol. 2002;55:1293–310.PubMedCrossRefGoogle Scholar
- 20.Sack MN, Harrington LS, Jonassen AK, Mjøs OD, Yellon DM. Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy in spontaneously hypertensive rats. Cardiovasc Drugs Ther. 2000;14:31–9.PubMedCrossRefGoogle Scholar
- 21.Tiivel T, Kadaya L, Kuznetsov A, Käämbre T, Peet N, Sikk P, Braun U, Ventura-Clapier R, Saks V, Seppet EK. Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Mol Cell Biochem. 2000;208:119–28.PubMedCrossRefGoogle Scholar
- 22.Hoerter JA, Kuznetsov A, Ventura-Clapier R. Functional development of the creatine kinase system in perinatal rabbit heart. Circ Res. 1991;69:665–76.PubMedCrossRefGoogle Scholar
- 23.Dröse S, Brandt U. Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv Exp Med Biol. Mitochondrial Oxidative Phosphorylation: Springer. 2012;748:145–69.Google Scholar
- 24.Marín-García J. Heart failure: bench to bedside. New York: Humana Press; 2010.CrossRefGoogle Scholar
- 25.Nulton-Persson AC, Szweda LI. Modulation of mitochondrial function by hydrogen peroxide. J Biol Chem. 2001;276:23357–61.PubMedCrossRefGoogle Scholar
- 26.Wang JX, Jiao JQ, Li Q, Long B, Wang K, Liu JP, Li YR, Li PF. miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nat Med. 2011;17:71–8.PubMedCrossRefGoogle Scholar
- 27.Li J, Donath S, Li Y, Qin D, Prabhakar BS, Li P. miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway. PLoS Genet. 2010;6:e1000795.PubMedPubMedCentralCrossRefGoogle Scholar
- 28.Long B, Wang K, Li N, Murtaza I, Xiao JY, Fan YY, Liu CY, Li WH, Cheng Z, Li P. miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor. Free Radic Biol Med. 2013;65:371–9.PubMedPubMedCentralCrossRefGoogle Scholar
- 29.Li J, Li Y, Jiao J, Wang J, Li Y, Qin D, Li P. Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis. Mol Cell Biol. 2014;34:1788–99.PubMedPubMedCentralCrossRefGoogle Scholar
- 30.Das S, Ferlito M, Kent OA, Fox-Talbot K, Wang R, Liu D, Raghavachari N, Yang Y, Wheelan SJ, Murphy E, Steenbergen C. Nuclear miRNA regulates the mitochondrial genome in the heart. Circ Res. 2012;110:1596–603.PubMedPubMedCentralCrossRefGoogle Scholar
- 31.Barrey E, Saint-Auret G, Bonnamy B, Damas D, Boyer O, Gidrol X. Pre-microRNA and mature microRNA in human mitochondria. PLoS ONE. 2011;6:e20220.PubMedPubMedCentralCrossRefGoogle Scholar
- 32.Das S, Bedja D, Campbell N, Dunkerly B, Chenna V, Maitra A, Steenbergen C. miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo. PLoS ONE. 2014;9:e96820.PubMedPubMedCentralCrossRefGoogle Scholar
- 33.Dasgupta N, Peng Y, Tan Z, Ciraolo G, Wang D, Li R. miRNAs in mtDNA-less cell mitochondria. Cell Death Discov. 2015;1:15004.PubMedPubMedCentralCrossRefGoogle Scholar
- 34.Jagannathan R, Thapa D, Nichols CE, Shepherd DL, Stricker JC, Croston TL, Baseler WA, Lewis SE, Martinez I, Hollander JM. Translational regulation of the mitochondrial genome following redistribution of mitochondrial microRNA in the diabetic heart. Circ Cardiovasc Genet. 2015;8:785–802.PubMedPubMedCentralCrossRefGoogle Scholar
- 35.Srinivasan H, Das S. Mitochondrial miRNA (MitomiR): a new player in cardiovascular health. Can J Physiol Pharmacol. 2015;93:855–61.PubMedCrossRefGoogle Scholar
- 36.Zhang X, Zuo X, Yang B, Li Z, Xue Y, Zhou Y, Huang J, Zhao X, Zhou J, Yan Y, Zhang H, Guo P, Sun H, Guo L, Zhang Y, Fu XD. MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell. 2014;158:607–19.PubMedPubMedCentralCrossRefGoogle Scholar
- 37.Li H, Zhang X, Wang F, Zhou L, Yin Z, Fan J, Nie X, Wang P, Fu XD, Chen C, Wang DW. MicroRNA-21 lowers blood pressure in spontaneous hypertensive rats by upregulating mitochondrial translation. Circulation. 2016;134:734–51.PubMedCrossRefGoogle Scholar
- 38.Beitzinger M, Peters L, Zhu JY, Kremmer E, Meister G. Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol. 2007;4:76–84.PubMedCrossRefGoogle Scholar
- 39.Hock J, Weinmann L, Ender C, Rudel S, Kremmer E, Raabe M, Urlaub H, Meister G. Proteomic and functional analysis of argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007;8:1052–60.PubMedPubMedCentralCrossRefGoogle Scholar
- 40.Maniataki E, Mourelatos Z. Human mitochondrial tRNAMet is exported to the cytoplasm and associates with the argonaute 2 protein. RNA. 2005;11:849–52.PubMedPubMedCentralCrossRefGoogle Scholar
- 41.Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008;132:875–86.PubMedPubMedCentralCrossRefGoogle Scholar
- 42.Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry Jr AV, Gardiner K, Head E, Feldman DS, Elton TS. Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun. 2008;370:473–7.PubMedPubMedCentralCrossRefGoogle Scholar
- 43.Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007;129:303–17.PubMedCrossRefGoogle Scholar
- 44.Moreadith RW, Batshaw ML, Ohnishi T, Kerr D, Knox B, Jackson D, Hruban R, Olson J, Reynafarje B, Lehninger AL. Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase (complex I) in an infant with congenital lactic acidosis. J Clin Invest. 1984;74:685–97.PubMedPubMedCentralCrossRefGoogle Scholar
- 45.Feinberg MW, Moore KJ. MicroRNA regulation of atherosclerosis. Circ Res. 2016;118:703–20.PubMedPubMedCentralCrossRefGoogle Scholar
- 46.Novak J, Olejnickova V, Tkacova N, Santulli G. Mechanistic role of microRNAs in coupling lipid metabolism and atherosclerosis. Adv Exp Med Biol. 2015;887:79–100.PubMedPubMedCentralCrossRefGoogle Scholar
- 47.Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Naar AM. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010;328:1566–9.PubMedCrossRefGoogle Scholar
- 48.Ramirez CM, Davalos A, Goedeke L, Salerno AG, Warrier N, Cirera-Salinas D, Suarez Y, Fernandez-Hernando C. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2011;31:2707–14.PubMedPubMedCentralCrossRefGoogle Scholar
- 49.Kim J, Yoon H, Ramirez CM, Lee SM, Hoe HS, Fernandez-Hernando C, Kim J. MiR-106b impairs cholesterol efflux and increases Abeta levels by repressing ABCA1 expression. Exp Neurol. 2012;235:476–83.PubMedCrossRefGoogle Scholar
- 50.de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldan A, Esau C, Edwards PA. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res. 2013;112:1602–12.PubMedPubMedCentralCrossRefGoogle Scholar
- 51.Ramirez CM, Goedeke L, Rotllan N, Yoon JH, Cirera-Salinas D, Mattison JA, Suarez Y, de Cabo R, Gorospe M, Fernandez-Hernando C. MicroRNA 33 regulates glucose metabolism. Mol Cell Biol. 2013;33:2891–902.PubMedPubMedCentralCrossRefGoogle Scholar
- 52.Goedeke L, Rotllan N, Canfran-Duque A, Aranda JF, Ramirez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasuncion MA, Naar AM, Suarez Y, Fernandez-Hernando C. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med. 2015;21:1280–9.PubMedPubMedCentralCrossRefGoogle Scholar
- 53.Meiler S, Baumer Y, Toulmin E, Seng K, Boisvert WA. MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:323–31.PubMedCrossRefGoogle Scholar
- 54.Rayner KJ, Suarez Y, Davalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernandez-Hernando C. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570–3.PubMedPubMedCentralCrossRefGoogle Scholar
- 55.Marquart TJ, Allen RM, Ory DS, Baldan A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci U S A. 2010;107:12228–32.PubMedPubMedCentralCrossRefGoogle Scholar
- 56.Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, Leclercq IA, MacDougald OA, Bommer GT. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem. 2010;285:33652–61.PubMedPubMedCentralCrossRefGoogle Scholar
- 57.Bommer GT, MacDougald OA. Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus. Cell Metab. 2011;13:241–7.PubMedPubMedCentralCrossRefGoogle Scholar
- 58.Xu X, So JS, Park JG, Lee AH. Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP. Semin Liver Dis. 2013;33:301–11.PubMedPubMedCentralCrossRefGoogle Scholar
- 59.Goedeke L, Vales-Lara FM, Fenstermaker M, Cirera-Salinas D, Chamorro-Jorganes A, Ramirez CM, Mattison JA, de Cabo R, Suarez Y, Fernandez-Hernando C. A regulatory role for microRNA 33* in controlling lipid metabolism gene expression. Mol Cell Biol. 2013;33:2339–52.PubMedPubMedCentralCrossRefGoogle Scholar
- 60.Tibiche C, Wang E. MicroRNA regulatory patterns on the human metabolic network. Open Syst Biol J. 2008;1:1–8.CrossRefGoogle Scholar
- 61.Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124–36.PubMedCrossRefGoogle Scholar
- 62.Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res. 1990;66:913–31.PubMedCrossRefGoogle Scholar
- 63.Steenbergen C, Perlman ME, London RE, Murphy E. Mechanism of preconditioning. Ionic alterations. Circ Res. 1993;72:112–25.PubMedCrossRefGoogle Scholar
- 64.He B, Xiao J, Ren AJ, Zhang YF, Zhang H, Chen M, Xie B, Gao XG, Wang YW. Role of miR-1 and miR-133a in myocardial ischemic postconditioning. J Biomed Sci. 2011;18:22.PubMedPubMedCentralCrossRefGoogle Scholar
- 65.Zhu WS, Guo W, Zhu JN, Tang CM, Fu YH, Lin QX, Tan N, Shan ZX. Hsp90aa1: a novel target gene of miR-1 in cardiac ischemia/reperfusion injury. Sci Rep. 2016;6:24498.PubMedPubMedCentralCrossRefGoogle Scholar
- 66.Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev. 2008;88:581–609.PubMedPubMedCentralCrossRefGoogle Scholar
- 67.Steenbergen C, Das S, Su J, Wong R, Murphy E. Cardioprotection and altered mitochondrial adenine nucleotide transport. Basic Res Cardiol. 2009;104:149–56.PubMedPubMedCentralCrossRefGoogle Scholar
- 68.Luo R, Wang Y, Xu P, Cao G, Zhao Y, Shao X, Li YX, Chang C, Peng C, Wang YL. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. Sci Rep. 2016;6:19588.PubMedPubMedCentralCrossRefGoogle Scholar
- 69.Fasanaro P, D’Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem. 2008;283:15878–83.PubMedPubMedCentralCrossRefGoogle Scholar
- 70.Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation. 2010;122:S124–31.PubMedPubMedCentralCrossRefGoogle Scholar
- 71.Mutharasan RK, Nagpal V, Ichikawa Y, Ardehali H. microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects. Am J Physiol Heart Circ Physiol. 2011;301:H1519–30.PubMedPubMedCentralCrossRefGoogle Scholar
- 72.Chen Z, Li Y, Zhang H, Huang P, Luthra R. Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene. 2010;29:4362–8.PubMedCrossRefGoogle Scholar
- 73.Colleoni F, Padmanabhan N, Yung HW, Watson ED, Cetin I, Tissot van Patot MC, Burton GJ, Murray AJ. Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition. PLoS ONE. 2013;8:e55194.PubMedPubMedCentralCrossRefGoogle Scholar
- 74.Bienertova-Vasku J, Sana J, Slaby O. The role of microRNAs in mitochondria in cancer. Cancer Lett. 2013;336:1–7.PubMedCrossRefGoogle Scholar
- 75.Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, Han S, Li S, Li J. Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing beclin 1-mediated autophagy. Neurochem Res. 2014;39:1279–91.PubMedCrossRefGoogle Scholar
- 76.Li W, Zhang X, Zhuang H, Chen HG, Chen Y, Tian W, Wu W, Li Y, Wang S, Zhang L, Chen Y, Li L, Zhao B, Sui S, Hu Z, Feng D. MicroRNA-137 is a novel hypoxia-responsive microRNA that inhibits mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX. J Biol Chem. 2014;289:10691–701.PubMedPubMedCentralCrossRefGoogle Scholar
- 77.Li RC, Tao J, Guo YB, Wu HD, Liu RF, Bai Y, Lv ZZ, Luo GZ, Li LL, Wang M, Yang HQ, Gao W, Han QD, Zhang YY, Wang XJ, Xu M, Wang SQ. In vivo suppression of microRNA-24 prevents the transition toward decompensated hypertrophy in aortic-constricted mice. Circ Res. 2013;112:601–5.PubMedPubMedCentralCrossRefGoogle Scholar
- 78.Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D. miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med. 2011;208:549–60.PubMedPubMedCentralCrossRefGoogle Scholar
- 79.van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA, Olson EN. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A. 2006;103:18255–60.PubMedPubMedCentralCrossRefGoogle Scholar
- 80.Li DF, Tian J, Guo X, Huang LM, Xu Y, Wang CC, Wang JF, Ren AJ, Yuan WJ, Lin L. Induction of microRNA-24 by HIF-1 protects against ischemic injury in rat cardiomyocytes. Physiol Res. 2012;61:555–65.PubMedGoogle Scholar
- 81.Gao P, Tchernyshyov I, Chang TC, Lee YS, Kita K, Ochi T, Zeller KI, De Marzo AM, Van Eyk JE, Mendell JT, Dang CV. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature. 2009;458:762–5.PubMedPubMedCentralCrossRefGoogle Scholar
- 82.Meloni M, Marchetti M, Garner K, Littlejohns B, Sala-Newby G, Xenophontos N, Floris I, Suleiman MS, Madeddu P, Caporali A, Emanueli C. Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction. Mol Ther. 2013;21:1390–402.PubMedPubMedCentralCrossRefGoogle Scholar
- 83.Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation. 2011;124:720–30.PubMedCrossRefGoogle Scholar
- 84.Yang KC, Bonini MG, Dudley Jr SC. Mitochondria and arrhythmias. Free Radic Biol Med. 2014;71:351–61.PubMedPubMedCentralCrossRefGoogle Scholar
- 85.Tong WH, Rouault T. Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. EMBO J. 2000;19:5692–700.PubMedPubMedCentralCrossRefGoogle Scholar
- 86.Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009;10:273–84.PubMedPubMedCentralCrossRefGoogle Scholar
- 87.Puissegur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouyssegur J, Gounon P, Hofman P, Barbry P, Mari B. miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ. 2011;18:465–78.PubMedCrossRefGoogle Scholar
- 88.Li Y, Park JS, Deng JH, Bai Y. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. J Bioenerg Biomembr. 2006;38:283–91.PubMedPubMedCentralCrossRefGoogle Scholar
- 89.Aschrafi A, Schwechter AD, Mameza MG, Natera-Naranjo O, Gioio AE, Kaplan BB. MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons. J Neurosci. 2008;28:12581–90.PubMedPubMedCentralCrossRefGoogle Scholar
- 90.Zheng SQ, Li YX, Zhang Y, Li X, Tang H. MiR-101 regulates HSV-1 replication by targeting ATP5B. Antivir Res. 2011;89:219–26.PubMedCrossRefGoogle Scholar
- 91.Willers IM, Martinez-Reyes I, Martinez-Diez M, Cuezva JM. miR-127-5p targets the 3′UTR of human beta-F1-ATPase mRNA and inhibits its translation. Biochim Biophys Acta. 2012;1817:838–48.PubMedCrossRefGoogle Scholar
- 92.Meng C, Jin X, Xia L, Shen SM, Wang XL, Cai J, Chen GQ, Wang LS, Fang NY. Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats. J Proteome Res. 2009;8:2463–75.PubMedCrossRefGoogle Scholar
- 93.Jullig M, Hickey AJ, Chai CC, Skea GL, Middleditch MJ, Costa S, Choong SY, Philips AR, Cooper GJ. Is the failing heart out of fuel or a worn engine running rich? A study of mitochondria in old spontaneously hypertensive rats. Proteomics. 2008;8:2556–72.PubMedCrossRefGoogle Scholar
- 94.Ding Y, Xia B, Yu J, Leng J, Huang J. Mitochondrial DNA mutations and essential hypertension (review). Int J Mol Med. 2013;32:768–74.PubMedGoogle Scholar
- 95.Meyers DE, Basha HI, Koenig MK. Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management. Tex Heart Inst J. 2013;40:385–94.PubMedPubMedCentralGoogle Scholar
- 96.Casademont J, Miro O. Electron transport chain defects in heart failure. Heart Fail Rev. 2002;7:131–9.PubMedCrossRefGoogle Scholar
- 97.Marin-Garcia J, Goldenthal MJ. Understanding the impact of mitochondrial defects in cardiovascular disease: a review. J Card Fail. 2002;8:347–61.PubMedCrossRefGoogle Scholar
- 98.Wijnen WJ, van der Made I, van den Oever S, Hiller M, de Boer BA, Picavet DI, Chatzispyrou IA, Houtkooper RH, Tijsen AJ, Hagoort J, van Veen H, Everts V, Ruijter JM, Pinto YM, Creemers EE. Cardiomyocyte-specific miRNA-30c over-expression causes dilated cardiomyopathy. PLoS ONE. 2014;9:e96290.PubMedPubMedCentralCrossRefGoogle Scholar
- 99.Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van der Made I, Herias V, van Leeuwen RE, Schellings MW, Barenbrug P, Maessen JG, Heymans S, Pinto YM, Creemers EE. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res. 2009;104:170–8. 6p following 178PubMedCrossRefGoogle Scholar
- 100.Leptidis S, El Azzouzi H, Lok SI, de Weger R, Olieslagers S, Kisters N, Silva GJ, Heymans S, Cuppen E, Berezikov E, De Windt LJ, da Costa Martins P. A deep sequencing approach to uncover the miRNOME in the human heart. PLoS ONE. 2013;8:e57800.PubMedPubMedCentralCrossRefGoogle Scholar
- 101.Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation. 2007;116:258–67.PubMedCrossRefGoogle Scholar
- 102.Soh J, Iqbal J, Queiroz J, Fernandez-Hernando C, Hussain MM. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med. 2013;19:892–900.PubMedPubMedCentralCrossRefGoogle Scholar
- 103.Poggesi C, Ho CY. Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation? J Muscle Res Cell Motil. 2014;35:37–45.PubMedPubMedCentralCrossRefGoogle Scholar
- 104.Guclu A, Germans T, Witjas-Paalberends ER, Stienen GJ, Brouwer WP, Harms HJ, Marcus JT, Vonk AB, Stooker W, Yilmaz A, Klein P, Ten Berg JM, Kluin J, Asselbergs FW, Lammertsma AA, Knaapen P, van Rossum AC, van der Velden J. ENerGetIcs in hypertrophic cardiomyopathy: traNslation between MRI, PET and cardiac myofilament function (ENGINE study). Neth Heart J. 2013;21:567–71.PubMedPubMedCentralCrossRefGoogle Scholar
- 105.Song L, Su M, Wang S, Zou Y, Wang X, Wang Y, Cui H, Zhao P, Hui R, Wang J. MiR-451 is decreased in hypertrophic cardiomyopathy and regulates autophagy by targeting TSC1. J Cell Mol Med. 2014;18:2266–74.PubMedPubMedCentralCrossRefGoogle Scholar
- 106.Bagnall RD, Tsoutsman T, Shephard RE, Ritchie W, Semsarian C. Global microRNA profiling of the mouse ventricles during development of severe hypertrophic cardiomyopathy and heart failure. PLoS ONE. 2012;7:e44744.PubMedPubMedCentralCrossRefGoogle Scholar
- 107.Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD. Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes. 2014;63:3805–14.PubMedPubMedCentralCrossRefGoogle Scholar
- 108.Morita S, Horii T, Kimura M, Hatada I. MiR-184 regulates insulin secretion through repression of Slc25a22. Peer J. 2013;1:e162.PubMedPubMedCentralCrossRefGoogle Scholar
- 109.Barath R HJ, Hollander JM, Das S. Mitochondrial miRNAs in diabetes: just the tip of the iceberg. Can J Physiol Pharmacol. 2017. (in press).Google Scholar
Copyright information
© Springer International Publishing AG 2017