Tumor Oxygenation Status: Facts and Fallacies

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 977)

Abstract

In this chapter we allude to a series of facts and fallacies often encountered in the description of tumor hypoxia, a relevant trait of the tumor microenvironment and a paramount driver of tumor aggressiveness and treatment resistance. The critical role of diffusion distances, terminological inconsistencies considering O2 partial pressures vs. O2 concentrations and with it the use of inept units, the impact of O2 depletion on proliferation and cell viability, the switch in the Warburg dogma, the distribution of hypoxic subvolumes within a tumor, the involvement of O2 diffusion shunts in the development of chronic hypoxia, and the role of endogenous biomarkers as surrogates for the assessment of hypoxia are discussed in more detail. Special emphasis is put on the clinical relevance of these misconceptions and misinterpretations and their impact on the assessment of hypoxia as well as hypoxia-targeted treatment planning.

Keywords

Tumor hypoxia Oxygen diffusion distances Hypoxia- inducible factor (HIF) Hypoxia- inducible biomarkers Warburg dogma 

Notes

Acknowledgment

The authors would like to thank Professor Gabriele Multhoff, Dept. Radiooncology and Radiotherapy, Klinikum rechts der Isar, Technical University Munich, for providing FaDu tumors for hypoxia distance metrics.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Radiation Oncology and Radiotherapy, Tumor Pathophysiology DivisionUniversity Medical CenterMainzGermany

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