Skip to main content
SpringerLink
Log in

Extracorporeal Photopheresis in Hematopoietic Cell Transplantation

  • Chapter
  • First Online:
Best Practices of Apheresis in Hematopoietic Cell Transplantation

  • 504 Accesses

Abstract

Extracorporeal photopheresis (ECP) combines the collection of white blood cells treated with 8-methoxypsoralen (8-MOP), photoactivation with ultraviolet A, and reinfusion of the treated cells into the patient. It was primarily developed for the treatment of cutaneous T-cell lymphoma but now has been established as a second-line treatment for acute and chronic graft-versus-host disease (GvHD). ECP can either be performed “in-line” by a single instrument or “off-line” by the combination of a blood cell separator with a photoactivation device. Side effects of ECP are usually mild and not associated with systemic immunosuppression. The mechanism of action is still incompletely understood. The efficacy of ECP in acute GvHD has been shown both in animal models and in clinical studies. Clinical response to ECP in patients with acute GvHD is significantly associated with a lower transplant-related mortality (TRM). The therapeutic action of ECP in steroid-dependent and steroid-refractory chronic GvHD has been demonstrated by a large body of clinical data including a prospective randomized trial. Steroid-sparing effect is a key feature of this therapeutic modality. Future perspectives of ECP comprise its introduction into first-line GvHD treatment and prevention strategies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abu-Dalle I, Reljic T, Nishihori T et al (2014) Extracorporeal photopheresis in steroid-refractory acute or chronic graft-versus-host disease: results of a systematic review of prospective studies. Biol Blood Marrow Transplant 20:1677–1686

    Article  PubMed  Google Scholar 

  • Alfred A, Taylor PC, Dignan F et al (2017) The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society. Brit J Haematol 177:287–310

    Article  Google Scholar 

  • Andreu G, Leon A, Heshmati F et al (1994) Extracorporeal photochemotherapy: evaluation of two techniques and use in connective tissue disorders. Transfus Sci 15:443–454

    Article  CAS  PubMed  Google Scholar 

  • Apisarnthanarax N, Donato M, Korbling M et al (2003) Extracorporeal photopheresis therapy in the management of steroid-refractory or steroid-dependent cutaneous chronic graft-versus-host disease after allogeneic stem cell transplantation: feasibility and results. Bone Marrow Transplant 31:459–465

    Article  CAS  PubMed  Google Scholar 

  • Apsner R, Uenver B, Sunder-Plassmann G et al (2002) Regional anticoagulation with acid citrate dextrose-A for extracorporeal photoimmunochemotherapy. Vox Sang 83:222–226

    Article  CAS  PubMed  Google Scholar 

  • Berger C, Hoffmann K, Vasquez JG (2010) Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy. Blood 116:4838–4847

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berger M, Albiani R, Sini B, Fagioli F (2015) Extracorporeal photopheresis for graft-versus-host disease: the role of patient, transplant, and classification criteria and hematologic values on outcome-results from a large single-center study. Transfusion 55:736–747

    Article  PubMed  Google Scholar 

  • Besnier DP, Chabannes D, Mahe B et al (1997) Treatment of graft-versus-host disease by extracorporeal photochemotherapy. Transplantation 64:49–54

    Article  CAS  PubMed  Google Scholar 

  • Bethge W, Kerbauy FR, Santos EB (2014) Extracorporeal photopheresis combined with pentostatin in the conditioning regimen for canine hematopoietic cell transplantation does not prevent GVHD. Bone Marrow Transplant 49:1198–1204

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Biagi E, Di Biaso I, Leoni V et al (2007) Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+Foxp3 + CD62L+ functional regulatory T-cells in patients with graft-versus-host disease. Transplantation 84:31–39

    Article  CAS  PubMed  Google Scholar 

  • Bisaccia E, Palangio M, Gonzalez J et al (2006) Treatment of extensive chronic graft-versus-host disease with extracorporeal photochemotherapy. J Clin Apher 21:181–187

    Article  PubMed  Google Scholar 

  • Bladon J, Taylor PC (1999) Extracorporeal photopheresis induces apoptosis in the lymphocytes of cutaneous T-cell lymphoma and graft-versus-host disease patients. Br J Haematol 107:707–711

    Article  CAS  PubMed  Google Scholar 

  • Brosig A, Hähnel V, Orsó E et al (2016) Technical comparison of four different photopheresis systems. Transfusion 56:2510–2519

    Article  CAS  PubMed  Google Scholar 

  • Brownback KR, Simpson SQ, Pitts LR et al (2016) Effect of extracorporeal photopheresis on lung function decline for severe bronchiolitis obliterans syndrome following allogeneic stem cell transplantation. J Clin Apher 31:347–352

    Article  PubMed  Google Scholar 

  • Budde H, Kolb S, Salinas Tejedor L et al (2014) Modified extracorporeal photopheresis with cells from a healthy donor for acute graft-versus-host disease in a mouse model. PLoS One 9:e105896

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Calore E, Calo A, Tridello G et al (2008) Extracorporeal photochemotherapy may improve outcome in children with acute GVHD. Bone Marrow Transplant 42:421–425

    Article  CAS  PubMed  Google Scholar 

  • Calore E, Marson P, Pillon M et al (2015) Treatment of acute graft-versus-host disease in childhood with extracorporeal photochemotherapy/photopheresis: the Padova experience. Biol Blood Marrow Transplant 21:1963–1972

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheung E, Baerlocher MO, Asch M et al (2009) Venous access. A practical review for 2009. Can Fam Physician 55:494–496

    PubMed  PubMed Central  Google Scholar 

  • Child FJ, Ratnavel R, Watkins P et al (1999) Extracorporeal photopheresis (ECP) in the treatment of chronic graft-versus-host disease (GVHD). Bone Marrow Transplant 23:881–887

    Article  CAS  PubMed  Google Scholar 

  • Cooke KR, Luznik L, Sarantopoulos S et al (2017) The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. Biol Blood Marrow Transplant 23:211–234

    Article  PubMed  Google Scholar 

  • Couriel DR, Hosing C, Saliba R et al (2006) Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD. Blood 107:3074–3080

    Article  CAS  PubMed  Google Scholar 

  • Dall’Amico R, Messina C (2002) Extracorporeal photochemotherapy for the treatment of graft-versus-host disease. Ther Apher 6:296–304

    Article  PubMed  Google Scholar 

  • Dall’Amico R, Rosetti F, Zulian F et al (1997a) Photopheresis in pediatric patients with drug-resistant chronic graft-versus-host disease. Br J Hematol 97:848–854

    Article  Google Scholar 

  • Dall’Amico R, Rossetti F, Zulian F et al (1997b) Photopheresis in pediatric patients with drug-resistant chronic graft-versus-host disease. Brit J Haematol 97:848–854

    Article  Google Scholar 

  • Das-Gupta E, Greinix H, Jacobs R et al (2014) Extracorporeal photopheresis as second-line treatment for acute graft-versus-host disease: Impact on six month freedom from treatment failure. Haematologica 99:1746–1752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Del Fante C, Scudeller L, Virengo G et al (2012) Response and survival of patients with chronic graft-versus-host disease treated by extracorporeal photochemotherapy: a retrospective study according to classical and National Institutes of Health consensus. Transfusion 52:2007–2015

    Article  PubMed  Google Scholar 

  • Del Fante C, Scudeller L, Martinasso A et al (2016a) Comparison of two automated mononuclear cell collection systems in patients undergoing extracorporeal photopheresis: a prospective crossover equivalence study. Transfusion 56:2078–2084

    Article  PubMed  CAS  Google Scholar 

  • Del Fante C, Galasso T, Bernasconi P et al (2016b) Extracorporeal photopheresis as a new supportive therapy for bronchiolitis obliterans syndrome after allogeneic stem cell transplantation. Bone Marrow Transplant 51:728–731

    Article  PubMed  CAS  Google Scholar 

  • Dignan FL, Greenblatt D, Cox M et al (2012) Efficacy of bimonthly extracorporeal photopheresis in refractory chronic mucocutaneous GVHD. Bone Marrow Transplant 47:824–830

    Article  CAS  PubMed  Google Scholar 

  • Dignan FL, Aguilar S, Scarisbrick JJ et al (2014) Impact of extracorporeal photopheresis on skin scores and quality of life in patients with steroid-refractory chronic GVHD. Bone Marrow Transplant 49:704–708

    Article  CAS  PubMed  Google Scholar 

  • Dittberner T, Schöttler E, Ranze O et al (2002) Heparin-induced thrombocytopenia: a complication in extracorporeal photochemotherapy (photopheresis). J Am Acad Dermatol 47:452–453

    Article  PubMed  Google Scholar 

  • Edelson RL (2014) Mechanistic insights into extracorporeal photochemotherapy: efficient induction of monocyte-to-dendritic cell maturation. Transfus Apher Sci 50:322–329

    Article  PubMed  Google Scholar 

  • Edelson R, Berger C, Gasparro F et al (1987) Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results. N Engl J Med 316:297–303

    Article  CAS  PubMed  Google Scholar 

  • Enomoto DNH, Schellekens PTA, Yong S-L et al (1997) Extracorporeal photochemotherapy (photopheresis) induces apoptosis in lymphocytes: a possible mechanism of action of PUVA therapy. Photochem Photobiol 65:177–180

    Article  CAS  PubMed  Google Scholar 

  • Ferrara JL, Levine JE, Reddy P, Holler E (2009) Graft-versus-host disease. Lancet 373:1550–1561

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Filipovich AH, Weisdorf D, Pavletic S et al (2005) National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant 11:945–955

    Article  PubMed  Google Scholar 

  • Flinn AM, Gennery AR (2017) Treatment of pediatric acute graft-versus-host disease-lessons from primary immunodeficiency? Front Immunol 8:328–338

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Florek M, Sega EI, Leveson-Gower DB et al (2014) Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models. Blood 124:1832–1842

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Flowers MED, Apperley J, von Besien K et al (2008) A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease. Blood 112:2667–2674

    Article  CAS  PubMed  Google Scholar 

  • Flowers MED, Inamoto Y, Carpenter PA et al (2011) Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institute of Health consensus criteria. Blood 117:3214–3219

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Foss FM, DiVenuti GM, Chin K et al (2005) Prospective study of extracorporeal photopheresis in steroid-refractory or steroid-resistant extensive chronic graft-versus-host disease: analysis of response and survival incorporating prognostic factors. Bone Marrow Transplant 35:1187–1193

    Article  CAS  PubMed  Google Scholar 

  • Franklin C, Cesko E, Hillen U et al (2015) Modulation and apoptosis of neutrophil granulocytes by extracorporeal photopheresis in the treatment of chronic graft- versus-host disease. PLoS One 10(8):e0134518. https://doi.org/10.1371/journal.pone.0134518

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Galloway S, Bodenham A (2004) Long-term central venous access. Br J Anaesth 92:722–734

    Article  CAS  PubMed  Google Scholar 

  • Garban F, Drillat P, Makowski C et al (2005) Extracorporeal chemophototherapy for the treatment of graft-versus-host disease: hematologic consequences of short-term, intensive courses. Haematologica 90:1096–1101

    PubMed  Google Scholar 

  • Garban F, Makowski C, Carras S et al (2014) Extracorporeal photopheresis: scientific and technical considerations for improving clinical management of patients. J Stem Cell Res Ther 4:232–236

    Google Scholar 

  • Gatza E, Rogers CE, Clouthier SG et al (2008) Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood 112:1515–1521

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gerber M, Gmeinhart B, Volc-Platzer B et al (1997) Complete remission of lichen-planus-like graft-versus-host-disease (GVHD) with extracorporeal photochemotherapy (ECP). Bone Marrow Transplant 19:517–519

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez-Vicent M, Ramirez M, Perez A et al (2008) Extracorporeal photochemotherapy for steroid-refractory graft-versus-host disease in low-weight pediatric patients. Immunomodulatory effects and clinical outcome. Haematologica 93:1278–1280

    Article  CAS  PubMed  Google Scholar 

  • Greinix HT, Volc-Platzer B, Rabitsch W et al (1998) Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood 92:3098–3104

    Article  CAS  PubMed  Google Scholar 

  • Greinix HT, Knobler RM, Worel N et al (2006a) The effect of intensified extracorporeal photochemotherapy on long-term survival in patients with severe acute graft-versus-host disease. Haematol 91:405–408

    Google Scholar 

  • Greinix HT, Socie G, Bacigalupo A et al (2006b) Assessing the potential role of photopheresis in hematopoietic stem cell transplant. Bone Marrow Transplant 38:265–273

    Article  CAS  PubMed  Google Scholar 

  • Greinix HT, Worel N, Knobler R (2010) Role of extracorporeal photopheresis (ECP) in treatment of steroid-refractory acute graft-versus-host disease. Biol Blood Marrow Transplant 16:1747–1748

    Article  PubMed  Google Scholar 

  • Greinix HT, van Besien K, Elmaagacli AH et al (2011) Progressive improvement in cutaneous and extracutaneous chronic graft-versus-host disease after a 24-week course of extracorporeal photopheresis–results of a crossover randomized study. Biol Blood Marrow Transplant 17:1775–1782

    Article  PubMed  Google Scholar 

  • Greinix HAT, Kuzmina Z, Weigl R et al (2015) CD19+CD21low B cells and CD4+CD45RA+CD31+ T cells correlate with first diagnosis of chronic graft-versus-host disease. Biol Blood Marrow Transplant 21:250–258

    Article  CAS  PubMed  Google Scholar 

  • Hackstein H, Amoros JJV, Bein G et al (2014) Successful use of miniphotopheresis for the treatment of graft-versus-host disease. Transfusion 54:2022–2027

    Article  PubMed  Google Scholar 

  • Hannani D (2015) Extracorporeal photopheresis: tolerogenic or immunogenic cell death? Beyond current dogma. Front Immunol 6:349–352

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hautmann AH, Wolff D, Hahn J et al (2013) Extracorporeal photopheresis in 62 patients with acute and chronic GVHD: Results of treatment with the COBE Spectra system. Bone Marrow Transplant 48:439–445

    Article  CAS  PubMed  Google Scholar 

  • Heng AE, Sauvezie B, Genestier L et al (2003) PUVA apoptotic response in activated and resting human lymphocytes. Transfus Apher Sci 28:43–50

    Article  CAS  PubMed  Google Scholar 

  • Ivancic E, Knobler R, Quehenberger P et al (2005) The course of anticoagulation after extracorporeal photochemotherapy. Photoderm Photoimmunol Photomed 21:150–151

    Article  CAS  Google Scholar 

  • Jagasia MH, Savani BN, Stricklin G et al (2009) Classic and overlap chronic graft-versus-host disease (cGVHD) is associated with superior outcome after extracorporeal photopheresis (ECP). Biol Blood Marrow Transplant 15:1288–1295

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jagasia M, Arora M, Flowers MED et al (2012) Risk factors for acute GVHD and survival after hematopoietic cell transplantation. Blood 119:296–307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jagasia M, Greinix H, Robin M et al (2013) Extracorporeal photopheresis versus anticytokine therapy as a second-line treatment for steroid-refractory acute GVHD: A multicentre comparative analysis. Biol Blood Marrow Transplant 19:1124–1133

    Article  CAS  Google Scholar 

  • Jagasia MH, Greinix HT, Arora M et al (2015) National Institutes of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant 21:389–401

    Article  PubMed  Google Scholar 

  • Jagasia M, Greinix H, Scheid C et al (2017) A randomized controlled study of extracorporeal photopheresis (ECP) therapy with UVADEX (methoxsalen) for National Institutes of Health (NIH)-graded moderate to severe chronic graft-versus-host disease (cGvHD). Blood 130:1970

    Google Scholar 

  • Joly E, Hudrisier D (2003) What is trogocytosis and what is its purpose? Nat Immunol 4:815

    Article  CAS  PubMed  Google Scholar 

  • Kanold J, Merlin E, Halle P et al (2007) Photopheresis in pediatric graft-versus-host disease after allogeneic marrow transplantation: clinical practice guidelines based on field experience and review of the literature. Transfusion 47:2276–2289

    Article  PubMed  Google Scholar 

  • Kitko CL, Levine JE (2015) Extracorporeal photopheresis in prevention and treatment of acute GVHD. Transfus Apher Sci 52:151–156

    Article  PubMed  Google Scholar 

  • Kitko CL, Braun T, Couriel DR et al (2016) Combination therapy for graft-versus-host disease prophylaxis with etanercept and extracorporeal photopheresis: results of a phase II clinical trial. Biol Blood Marrow Transplant 22:862–868

    Article  CAS  PubMed  Google Scholar 

  • Knobler RM, Trautinger F, Graninger W et al (1993) Parenteral application of 8-methoxypsoralen during photopheresis. J Am Acad Dermatol 28:580–584

    Article  CAS  PubMed  Google Scholar 

  • Knobler R, Berlin G, Calzavara-Pinton P et al (2014) Guidelines on the use of extracorporeal photopheresis. J Eur Acad Dermatol Venereol 28(Suppl 1):1–37

    Article  CAS  PubMed  Google Scholar 

  • Kuzmina Z, Greinix HT, Weigl R et al (2011) Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia. Blood 117:2265–2274

    Article  CAS  PubMed  Google Scholar 

  • Lamioni A, Parisi F, Isacchi G et al (2005) The immunological effects of extracorporeal photopheresis unraveled: induction of tolerogenic dendritic cells in vitro and regulatory T-cells in vivo. Transplantation 79:846–850

    Article  PubMed  Google Scholar 

  • Lee SJ, Klein JP, Barrett AJ et al (2002) Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood 100:406–414

    Article  CAS  PubMed  Google Scholar 

  • Levine JE, Logan B, Wu J et al (2010) Graft-versus-host disease treatment: predictors of survival. Biol Blood Marrow Transplant 16:1693–1699

    Article  PubMed  PubMed Central  Google Scholar 

  • Lucid CE, Savani BN, Engelhardt BG et al (2011) Extracorporeal photopheresis in patients with refractory bronchiolitis obliterans developing after allo-SCT. Bone Marrow Transplant 46:426–429

    Article  CAS  PubMed  Google Scholar 

  • MacMillan M, DeFor TE, Weisdorf DJ (2010) The best endpoint for acute GVHD treatment trials. Blood 115:5412–5417

    Article  CAS  PubMed  Google Scholar 

  • Malagola M, Cancelli V, Skert C et al (2016) Extracorporeal photopheresis for treatment of acute and chronic graft versus host disease: an Italian multicentric retrospective analysis on 94 patients on behalf of the Gruppo Italiano Trapianto di Midollo Osseo. Transplantation 100:e147–e155

    Article  PubMed  Google Scholar 

  • Malik MI, Litzow M, Hogan W et al (2014) Extracorporeal photopheresis for chronic graft-versus-host disease: a systematic review and meta-analysis. Blood Res 49:100–106

    Article  PubMed  PubMed Central  Google Scholar 

  • Martin PJ, Carpenter PA, Sanders JE, Flowers ME (2004) Diagnosis and clinical management of chronic graft-versus-host disease. Int J Hematol 79:221–228

    Article  PubMed  Google Scholar 

  • Martin PJ, Rizzo JD, Wingard JR et al (2012) First-and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant 18:1150–1163

    Article  PubMed  PubMed Central  Google Scholar 

  • Martin PJ, Storer BE, Inamoto Y et al (2017) An endpoint associated with clinical benefit after initial treatment of chronic graft-versus-host disease. Blood 130:360–367

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Merlin E, Goncalves-Mendes N, Hannani D et al (2011) Extracorporeal photochemotherapy induces arginase 1 in patients with graft versus host disease. Transplant Immunol 24:100–106

    Article  CAS  Google Scholar 

  • Messina C, Locatelli F, Lanino E et al (2003) Extracorporeal photochemotherapy for paediatric patients with graft-versus-host disease after haematopoietic stem cell transplantation. Br J Haematol 122:118–127

    Article  CAS  PubMed  Google Scholar 

  • Michallet M, Sobh M, Garban F et al (2018) Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study. Leuk Lymph 59:372–380

    Article  Google Scholar 

  • Miller KB, Roberts TF, Chan G et al (2004) A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease. Bone Marrow Transplant 33:881–889

    Article  CAS  PubMed  Google Scholar 

  • Nedelcu E, Ziman A, Fernando LP et al (2008) Exclusive use of acid citrate dextrose for extracorporeal photopheresis in patients with contraindications to heparin: an effective protocol. J Clin Aph 23:66–73

    Article  Google Scholar 

  • Perfetti P, Carlier P, Strada P et al (2008) Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD. Bone Marrow Transplant 42:609–617

    Article  CAS  PubMed  Google Scholar 

  • Perotti C, Del Fante C, Tinelli C et al (2010) Extracorporeal photochemotherapy in graft-versus-host disease: a longitudinal study on factors influencing the response and survival in pediatric patients. Transfusion 50:1359–1369

    Article  PubMed  Google Scholar 

  • Perseghin P, Galimberti S, Balduzzi A et al (2007) Extracorporeal photochemotherapy for the treatment of chronic graft-versus-host disease: trend for a possible cell dose-related effect? Ther Apher Dial 11:85–93

    Article  PubMed  Google Scholar 

  • Pierelli L, Perseghin P, Marchetti M et al (2013) Extracorporeal photopheresis for the treatment of acute and chronic graft-versus-host disease in adults and children: best practice recommendations from an Italian Society of Hemapheresis and Cell Manipulation (SIdEM) and Italian Group for Bone Marrow Transplantation (GITMO) consensus process. Transfusion 53:2340–2352

    PubMed  Google Scholar 

  • Quaglino P, Comessatti A, Ponti R et al (2009) Reciprocal modulation of circulating CD4+CD25+bright T cells induced by extracorporeal photochemotherapy in cutaneous T-cell lymphoma and chronic graft-versus-host-disease patients. Int J Immunopathol Pharmacol 22:353–362

    Article  CAS  PubMed  Google Scholar 

  • Rieber N, Wecker I, Neri D et al (2014) Extracorporeal photopheresis increases neutrophilic myeloid-derived suppressor cells in patients with GvHD. Bone Marrow Transplant 49:545–552

    Article  CAS  PubMed  Google Scholar 

  • Rubegni P, Cuccia A, Sbano P et al (2005) Role of extracorporeal photochemotherapy in patients with refractory chronic graft-versus-host disease. Br J Haematol 130:271–275

    Article  CAS  PubMed  Google Scholar 

  • Salvaneschi L, Perotti C, Zecca M et al (2001) Extracorporeal photochemotherapy for treatment of acute and chronic GVHD in childhood. Transfusion 41:1299–1305

    Article  CAS  PubMed  Google Scholar 

  • Schmitt S, Johnson TS, Karakhanova S et al (2009) Extracorporeal photopheresis augments function of CD4 + CD25 + FoxP3 + regulatory T cells by triggering adenosine production. Transplantation 88:411–416

    Article  PubMed  Google Scholar 

  • Schooneman F (2003) Extracorporeal photopheresis technical aspects. Transfus Apher Sci 28:51–61

    Article  CAS  PubMed  Google Scholar 

  • Schwartz J, Winters JL, Padmanabhan A et al (2013) Clinical applications of therapeutic apheresis: an evidence based approach, 6th edition. J Clin Apheresis 28:145–284

    Article  PubMed  Google Scholar 

  • Seaton ED, Szydlo RM, Kanfer E et al (2003) Influence of extracorporeal photopheresis on clinical and laboratory parameters in chronic graft-versus-host disease and analysis of predictors of response. Blood 102:1217–1223

    Article  CAS  PubMed  Google Scholar 

  • Setterblad N, Garban F, Weigl R et al (2008) Extracorporeal photopheresis increases sensitivity of monocytes from patients with graft-versus-host disease to HLA-DR-mediated cell death. Transfusion 48:169–177

    PubMed  Google Scholar 

  • Shaughnessy PJ, Bolwell BJ, van Besien K et al (2009) Extracorporeal photopheresis for the prevention of acute GVHD in patients undergoing standard myeloablative conditioning and allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 45:1068–1076

    Article  PubMed  PubMed Central  Google Scholar 

  • Socie G, Stone JV, Wingard JR et al (1999) Long-term survival and late deaths after allogeneic bone marrow transplantation. Late effects working committee of the International bone marrow transplant registry. N Engl J Med 341:14–21

    Article  CAS  PubMed  Google Scholar 

  • Spisek R, Gasova Z, Bartunkova J (2006) Maturation state of dendritic cells during the extracorporeal photopheresis and its relevance for the treatment of chronic graft-versus-host disease. Transfusion 46:55–65

    Article  CAS  PubMed  Google Scholar 

  • Stewart BL, Storer B, Storek J et al (2004) Duration of immunosuppressive treatment for chronic graft-versus-host disease. Blood 104:3501–3506

    Article  CAS  PubMed  Google Scholar 

  • Tsirigotis P, Kapsimalli V, Baltadakis I et al (2012) Extracorporeal photopheresis in refractory chronic graft-versus-host disease: the influence on peripheral blood T cell subpopulations. A study by the Hellenic Association of Hematology. Transfus Apher Sci 46:181–188

    Article  PubMed  Google Scholar 

  • Ussowicz M, Musiał J, Mielcarek M et al (2013) Steroid-sparing effect of extracorporeal photopheresis in the therapy of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Transplant Proc 45:3375–3380

    Article  CAS  PubMed  Google Scholar 

  • Van Lint MT, Milone G, Leotta S et al (2006) Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti-thymocyte globulin. Blood 107:4177–4181

    Article  PubMed  CAS  Google Scholar 

  • Wolff D, Gerbitz A, Ayuk F et al (2010) Consensus Conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD. Biol Blood Marrow Transplant 16:1611–1628

    Article  PubMed  Google Scholar 

  • Wolff D, Schleuning M, von Harsdorf S et al (2011) Consensus conference on clinical practice in chronic GVHD: second-line treatment of chronic graft-versus-host disease. Biol Blood Marrow Transplant 17:1–17

    Article  PubMed  Google Scholar 

  • Wolff D, Ayuk F, Elmaagacli A et al (2013) Current practice in diagnosis and treatment of acute graft-versus-host disease: Results from a survey among German-Austrian-Swiss hematopoietic stem cell transplant centers. Biol Blood Marrow Transplant 19:767–776

    Article  PubMed  Google Scholar 

  • Yakut E, Jakobs C, Peric A et al (2015) Extracorporeal photopheresis promotes IL-1beta production. J Immunol 194:2569–2577

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinic of Internal Medicine I, Department of Transfusion Medicine, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany

    Kristina Hölig

  2. Division of Hematology, Medical University of Graz, Graz, Austria

    Hildegard Greinix

Authors
  1. Kristina Hölig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hildegard Greinix
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kristina Hölig .

Editor information

Editors and Affiliations

  1. Cancer Treatment Centers of America, Dept Hematology & Bone Marrow Transplantation, Deerfield, IL, USA

    Syed A. Abutalib

  2. BloodCenter of Wisconsin, Milwaukee, WI, USA

    Anand Padmanabhan

  3. Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA, USA

    Huy P. Pham

  4. Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria

    Nina Worel

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Hölig, K., Greinix, H. (2020). Extracorporeal Photopheresis in Hematopoietic Cell Transplantation. In: Abutalib, S., Padmanabhan, A., Pham, H., Worel, N. (eds) Best Practices of Apheresis in Hematopoietic Cell Transplantation. Advances and Controversies in Hematopoietic Transplantation and Cell Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-55131-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-55131-9_13

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55130-2

  • Online ISBN: 978-3-319-55131-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation