Sometimes, recruiting is the most important step in “filling a study.” The team should have two goals: a must-fill goal and an optimal goal, remembering that start-up costs are the same regardless of which goal is met. Flyers for medical facilities have a modicum of success as do giving presentations at medical speaking events, booths at health fairs or senior centers, or discussions at medical staff in-services. Referral letters to physicians can extend the site’s reputation. Electronic health records remain the biggest breakthrough in recruiting subjects, as long as some specific rules are followed. The future lies in social media, where the motivated subjects can self-select.