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Histone Posttranslational Modifications in Schizophrenia

  • Elizabeth A. Thomas
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 978)

Abstract

Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms. Epigenetic modifications, such as histone acetylation and methylation, as well as DNA methylation, can induce lasting changes in gene expression and have therefore been implicated in promoting the behavioral and neuronal behaviors that characterize this disorder. Importantly, because epigenetic processes are potentially reversible, they might serve as targets in the design of novel therapies in psychiatry. This chapter will review the current information regarding histone modifications in schizophrenia and the potential therapeutic relevance of such marks.

Keywords

Epigenetic Psychiatric CNS Therapeutic 

Abbreviations

HAT

histone acetyltransferase

HDAC

histone deacetylase

KDMs

lysine demethylases

KMT

lysine methyltransferases

polyI:C

polyinosinic-polycytidylic acid

PRMT

protein arginine methyltransferases

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Molecular and Cellular NeuroscienceThe Scripps Research InstituteLa JollaUSA

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