Cell Death in Ischemia-Reperfusion-Induced Liver Injury

  • Julie Goswami
  • Heather Waring
  • Allan Tsung
  • Hai Huang
Chapter
First Online:
Part of the Cell Death in Biology and Diseases book series (CELLDEATH)

Abstract

Hepatic ischemia-reperfusion injury (IRI) is incurred in a variety of disease processes and leads to profound local and systemic effects through hepatic cell death and the associated inflammatory response. Understanding mechanisms of cell death after hepatic IRI is essential for developing strategies to ameliorate its widespread effects. Classically, cell death has been attributed to apoptotic and necrotic pathways, both of which remain important in IRI. However, as we describe, numerous other pathways, including necroptosis, ferroptosis, pyroptosis, autophagy, and NETosis, may also play a role in this disease process.

Keywords

Hepatic Stellate Cell Mitochondrial Permeability Transition Innate Immune Cell Reactive Oxidant Species Liver Sinusoidal Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ASC

Apoptosis-associated speck-like protein-containing CARD

Atg

Autophagy

ATP

Adenosine triphosphate

Bax

Bcl-2-associated X

Bcl-2

B-cell lymphoma 2

BECN1

Beclin-1

Bid

BH3-interacting domain

CARS

Cysteinyl-tRNA-synthetase

c-FLIP

Cellular FLICE-like inhibitory protein

DAMP

Damage-associated molecular pattern

DC

Dendritic cell

FADD

Fas-associated death domain

GPX4

Glutathione peroxidase 4

GSH

Glutathione

GSSG

Oxidized glutathione

HMGB1

High-mobility group box protein 1

HSPB1

Heat shock protein beta 1

IRI

Ischemia-reperfusion injury

LSEC

Liver sinusoidal endothelial cell

MLKL

Mixed linkage kinase domain-like

MPT

Mitochondrial permeability transition

NASH

Non-alcoholic steatohepatitis

NET

Neutrophil extracellular trap

NLRP3

Nucleotide-binding domain, leucine-rich repeat containing protein 3

NOX

Nitrogen oxide

NRF2

Nuclear respiratory factor 2

PAD4

Peptidyl-arginine-deaminase-4

PI3K

Phosphatidylinositol-3-kinase

PKB

Protein kinase B

PTEN

Phosphate and tensin homologue

RIPK

Receptor-interacting protein kinase

ROS

Reactive oxidant species

RSL

RAS-selective lethal

TFR1

Transferrin receptor 1

TLR

Toll-like receptor

TRADD

TNF-receptor-associated death domain

TRAIL

TNF-related apoptosis-inducing ligand

TUNEL

Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling

VDAC

Voltage-dependent anion channel

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Julie Goswami
    • 1
  • Heather Waring
    • 1
  • Allan Tsung
    • 1
    • 2
  • Hai Huang
    • 1
  1. 1.Department of SurgeryUniversity of Pittsburgh Medical CenterPittsburghUSA
  2. 2.Division of Hepatobiliary and Pancreatic SurgeryUniversity of PittsburghPittsburghUSA

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