Biocompatible Magnesium Alloy ZNdK100—Adaptation of Extrusion Parameters to Tailor the Mechanical Properties to Different Implant Applications

  • Rainer Eifler
  • Florian Schäfke
  • Hans Jürgen Maier
  • Christian KloseEmail author
Conference paper
Part of the The Minerals, Metals & Materials Series book series (MMMS)


Neodymium containing magnesium alloys like MgNd2 and ZNdK100 offer high corrosion resistance and biocompatibility due to low amounts of alloying elements, and are thus attractive for biomedical applications. Compared with common bioresorbable magnesium alloys, which frequently contain mischmetal, the use of neodymium as a single rare earth element provides for good reproducibility of the degradation behavior while improving the ductility, leading to high fracture strains of 25–30%. Thus, stents made from these alloys allowed dilatation without failure. The MgNd2 alloy’s strength, however, turned out to be low. Recent investigations proved that the strength of a ZNdK100 alloy can be significantly increased by an adaptation of the extrusion parameters, such as billet temperature and extrusion ratio, which govern recrystallization of the microstructure. In the current study, it is demonstrated how the mechanical properties can be adjusted by the extrusion process, allowing the future use of the same alloy for both bone implants and soft tissue implants.


Bioresorbable implants Magnesium Neodymium Extrusion 



Part of this research was sponsored by the German Research Foundation (DFG) within the subproject R1 of the Collaborative Research Centre SFB 599.


  1. 1.
    C.M. Campos, T. Muramatsu, J. Iqbal, Y.-J. Zhang, Y. Onuma, H.M. Garcia-Garcia, M. Haude, P.A. Lemos, B. Warnack, P.W. Serruys, Bioresorbable drug-eluting magnesium-alloy scaffold for treatment of coronary artery disease. Int. J. Mol. Sci. 14, 24492–24500 (2013)CrossRefGoogle Scholar
  2. 2.
    J.-M. Seitz, A. Lucas, M. Kirschner, Magnesium-based compression screws: a novelty in the clinical use of implants. JOM 68, 1177–1182 (2016)CrossRefGoogle Scholar
  3. 3.
    X.-N. Gu, Y.-F. Zheng, A review on magnesium alloys as biodegradable materials. Front. Mater. Sci. Chin. 4, 111–115 (2010)CrossRefGoogle Scholar
  4. 4.
    J. Hofstetter, M. Becker, E. Martinelli, A.-M. Weinberg, B. Mingler, H. Kilian, S. Pogatscher, P.J. Uggowitzer, J.F. Löffler, High-strength low-alloy (HSLA) Mg–Zn–Ca alloys with excellent biodegradation performance. JOM 66, 566–572 (2014)CrossRefGoogle Scholar
  5. 5.
    I.S. Berglund, H.S. Brar, N. Dolgova, A.P. Acharya, B.G. Keselowsky, M. Sarntinoranont, M.V. Manuel, Synthesis and characterization of Mg-Ca-Sr alloys for biodegradable orthopedic implant applications. J. Biomed. Mater. Res. Part B 100B, 1524–1534 (2012)CrossRefGoogle Scholar
  6. 6.
    F. Witte, N. Hort, C. Vogt, S. Cohen, K.U. Kainer, R. Willumeit, F. Feyerabend, Degradable biomaterials based on magnesium corrosion. Curr. Opin. Solid State Mater. Sci. 12, 63–72 (2008)CrossRefGoogle Scholar
  7. 7.
    J.-M. Seitz, R. Eifler, J. Stahl, M. Kietzmann, F.-W. Bach, Characterization of MgNd2 alloy for potential applications in bioresorbable implantable devices. Acta Biomater. 8, 3852–3864 (2012)CrossRefGoogle Scholar
  8. 8.
    F. Feyerabend, J. Fischer, J. Holtz, F. Witte, R. Willumeit, H. Drücker, C. Vogt, N. Hort, Evaluation of short-term effects of rare earth and other elements used in magnesium alloys on primary cells and cell lines. Acta Biomater. 6, 1834–1842 (2010)CrossRefGoogle Scholar
  9. 9.
    M. Durisin, J.-M. Seitz, J. Reifenrath, C.M. Weber, R. Eifler, H.J. Maier, T. Lenarz, C. Klose, A novel biodegradable frontal sinus stent (MgNd2): a long-term animal study. Eur. Arch. Otorhinolaryngol. 273, 1455–1467 (2016)CrossRefGoogle Scholar
  10. 10.
    R. Eifler, J.-M. Seitz, C.M. Weber, S. Grundke, J. Reifenrath, M. Kietzmann, T. Lenarz, H.J. Maier, C. Klose, M. Durisin, MgNd2 alloy in contact with nasal mucosa. An in vivo and in vitro approach. J. Mater. Sci. Mater. Med. 27, 25 (2016)CrossRefGoogle Scholar
  11. 11.
    S.E. Ion, F.J. Humphreys, S.H. White, Dynamic recrystallisation and the development of microstructure during the high temperature deformation of magnesium. Acta Metall. 30, 1909–1919 (1982)CrossRefGoogle Scholar
  12. 12.
    A.C. Hänzi, A.S. Sologubenko, P. Gunde, M. Schinhammer, P.J. Uggowitzer, Design considerations for achieving simultaneously high-strength and highly ductile magnesium alloys. Philos. Mag. Lett. 92, 417–427 (2012)CrossRefGoogle Scholar

Copyright information

© The Minerals, Metals & Materials Society 2017

Authors and Affiliations

  • Rainer Eifler
    • 1
  • Florian Schäfke
    • 1
  • Hans Jürgen Maier
    • 1
  • Christian Klose
    • 1
    Email author
  1. 1.Institut für Werkstoffkunde (Materials Science)Leibniz Universität HannoverGarbsenGermany

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