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Development of Sponge Structure and Casting Conditions for Absorbable Magnesium Bone Implants

  • Stefan JulmiEmail author
  • Christian Klose
  • Ann-Kathrin Krüger
  • Peter Wriggers
  • Hans Jürgen Maier
Conference paper
Part of the The Minerals, Metals & Materials Series book series (MMMS)

Abstract

In the case of bone defects, there are two different methods to close such defects. One option is to use bone autografts, but therefore the bone graft has to be cut off from the same person’s hip. In this case the patient has to undergo an additional surgery, which bears complications, like causing inflammations. Absorbable, open-pored implants minimize these risks. Synthetic bone implants are typically made of ceramics, bioglass or polymers. In this study, magnesium alloys were investigated as absorbable porous bone substitute materials in which the bone can grow into. The main advantages are the design flexibility to produce individual implants by investment casting and mechanical properties similar to the bone. In order to adapt the degradation behavior to the bone’s ingrowth behavior, the implant material has to be alloyed and coated. Moreover, to meet the mechanical requirements, finite element simulations of the sponge structure were used during the design phase of the structures and compression tests were conducted for experimental validation.

Keywords

Sponge structure Absorbable magnesium Bone implants 

Notes

Acknowledgements

This research is sponsored by the German Research Foundation (DFG) within the project “Interfacial effects and ingrowing behavior of magnesium-based foams as bioresorbable bone substitute material” (grant no. MA 1175/52-1).

References

  1. 1.
    S.C. Manolagas, Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr.Soc. 21(2), 115–137 (2000)Google Scholar
  2. 2.
    P.C. Missiuna et al., Anatomically safe and minimally invasive transcrestal technique for procurement of autogenous cancellous bone graft from the mid-iliac crest. Can. J. Surg. 54(5), 327–332 (2011)CrossRefGoogle Scholar
  3. 3.
    A.J. Salgado, O.P. Coutinho, R.L. Reis, Bone tissue engineering: state of the art and future trends. Macromol. Biosci. 4, 743–765 (2004)CrossRefGoogle Scholar
  4. 4.
    Bone regeneration and repair, Biology and Clinical Applications (Humana Press Inc, Totowa, NJ, 2005)Google Scholar
  5. 5.
    T.V. Thamaraiselvi, S. Rajeswari, Biological evaluation of bioceramic materials: a review. Trends Biomater. Artif. Organs 18(1), 9–17 (2004)Google Scholar
  6. 6.
    X. Gu, Y. Zheng, A review on magnesium alloys as biodegradable materials. Frontiers Mater. Sci. China 4(2), 111–115 (2010)CrossRefGoogle Scholar
  7. 7.
    F. Witte et al., In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials 26, 3557–3563 (2005)CrossRefGoogle Scholar
  8. 8.
    H. Haferkamp et al., Develompent, processing and applications range of magnesium lithium alloys. Mater. Sci. Forum 350–351, 31–42 (2000)CrossRefGoogle Scholar
  9. 9.
    T.L. Chia et al., The effect of alloy composition on the microstructure and tensile properties of binary Mg-rare earth alloys. Intermetallics 17, 481–490 (2009)CrossRefGoogle Scholar
  10. 10.
    N. Birbilis et al., On the corrosion of binary magnesium-rare earth alloys. Corros. Sci. 51, 683–689 (2009)CrossRefGoogle Scholar
  11. 11.
    F. Bach et al., Magnesium sponges as a bioabsorbable material: attributes and challanges. Int. J. Mater. Res. 98, 609–612 (2007)CrossRefGoogle Scholar
  12. 12.
    J. Seitz et al., The effect of different sterilization methods on the mechanical strength of magnesium based implant materials. Adv. Eng. Mater. 13, 1146–1151 (2011)CrossRefGoogle Scholar
  13. 13.
    A. Weizbauer et al., Novel magnesium alloy Mg–2La caused no cytotoxic effects on cells in physiological conditions. Mater. Sci. Eng. C 41, 267–273 (2014)CrossRefGoogle Scholar
  14. 14.
    J. Reifenrath et al., Axial forces and bending moments in the loaded rabbit tibia in vivo. Acta Vet. Scand. 54(21), 1–7 (2012)Google Scholar
  15. 15.
  16. 16.
    J. Seitz et al., Comparison of the corrosion behavior of coated and uncoated magnesium alloys in an in vitro corrosion environment. Adv. Biomater. 13, B1–B11 (2011)Google Scholar
  17. 17.
    X. Gu et al., In vitro corrosion and biocompatibility of binary magnesium alloys. Biomaterials 30, 484–498 (2009)CrossRefGoogle Scholar

Copyright information

© The Minerals, Metals & Materials Society 2017

Authors and Affiliations

  • Stefan Julmi
    • 1
    Email author
  • Christian Klose
    • 1
  • Ann-Kathrin Krüger
    • 2
  • Peter Wriggers
    • 2
  • Hans Jürgen Maier
    • 1
  1. 1.Leibniz Universität Hannover, Institut für Werkstoffkunde (Materials Science)GarbsenGermany
  2. 2.Leibniz Universität Hannover, Institute of Continuum MechanicsHannoverGermany

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