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Upper Urinary Tract Carcinoma In Situ

  • Jay D. Raman
  • Joshua L. Warrick
  • Grant P. Redrow
  • Surena F. Matin
Chapter

Abstract

Upper tract carcinoma in situ (UTCIS) is a non-muscle invasive, high-grade cancer involving the epithelial lining of the renal pelvis, calyces, and ureter. While progression to muscle invasion or metastasis occurs infrequently, UTCIS remains a vexing clinical conundrum for diagnosis, therapy, and subsequent surveillance. Organ preservation remains a central tenet in the management of UTCIS with topical intracavitary instillation playing a critical role to achieve this goal. Nonetheless, owing to the uncommon presentation of UTCIS, treatment paradigms and algorithms are often extrapolated from management of bladder CIS. In that regard, acknowledging that the clinical behavior between these two entities is distinct, prospective evaluation focusing on the UTCIS patient cohort is critical for the future.

Keywords

Urothelial carcinoma Upper tract Carcinoma in situ (CIS) BCG 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Jay D. Raman
    • 1
  • Joshua L. Warrick
    • 2
  • Grant P. Redrow
    • 3
  • Surena F. Matin
    • 4
  1. 1.Division of UrologyPenn State Milton S. Hershey Medical CenterHersheyUSA
  2. 2.Department of PathologyPenn State Milton S. Hershey Medical CenterHersheyUSA
  3. 3.Department of Surgery (Urology)University of Texas HoustonHoustonUSA
  4. 4.Department of UrologyUniversity of Texas MD Anderson Cancer CenterHoustonUSA

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