Computational Biosensors: Molecules, Algorithms, and Detection Platforms

  • Elebeoba E. May
  • Jason C. Harper
  • Susan M. Brozik
Part of the Modeling and Optimization in Science and Technologies book series (MOST, volume 9)


Advanced nucleic acid-based sensor-applications require computationally intelligent biosensors that are able to concurrently perform complex detection and classification of samples within an in vitro platform. Realization of these cutting-edge computational biosensor systems necessitates innovation and integration of three key technologies: molecular probes with computational capabilities, algorithmic methods to enable in vitro computational post processing and classification, and immobilization and detection approaches that enable the realization of deployable computational biosensor platforms. We provide an overview of current technologies, including our contributions towards the development of computational biosensor systems.


Biomolecular logic systems Digital biosensors DNA computing Computational biosensors Intelligent biosensor Application- and Substrate-specific algorithms DNA detection Deoxyribozymes Enzymes 



We would like to thank our colleagues who collaborated on our original computational biosensor work: P. Dolan, P. Crozier, M. Lee, M. Manginell, and R. Polsky.

Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Elebeoba E. May
    • 1
  • Jason C. Harper
    • 2
  • Susan M. Brozik
    • 2
  1. 1.University of HustonHustonUSA
  2. 2.Sandia National LaboratoriesAlbuquerqueUSA

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