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Molecular Pathogenesis and Signal Transduction by Helicobacter pylori pp 253–275Cite as

Impact of the Microbiota and Gastric Disease Development by Helicobacter pylori

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 400))

Abstract

Microorganisms in humans form complex communities with important functions and differences in each part of the body. The stomach was considered to be a sterile organ until the discovery of Helicobacter pylori, but nowadays, it is possible to demonstrate that other microorganisms beyond H. pylori can colonize the gastric mucosa and that the diverse microbiota ecosystem of the stomach is different from the mouth and the esophagus, and also from the small intestine and large intestine. H. pylori seems to be the most important member of the gastric microbiota with the highest relative abundance when present, but when it is absent, the stomach has a diverse microbiota. Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, and Fusobacteria are the most abundant phyla in both H. pylori-positive and H. pylori-negative patients. The gastric commensal flora may play some role in the H. pylori-associated carcinogenicity, and differences in the gastric microbiota composition of patients with gastric cancer, intestinal metaplasia, and chronic gastritis are described. The gastric microbiota changed gradually from non-atrophic gastritis to intestinal metaplasia, and to gastric cancer (type intestinal).

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Authors and Affiliations

  1. Department of Microbiology, Instituto de Investigación Sanitaria Princesa, Hospital Universitario La Princesa, Madrid, Spain

    Teresa Alarcón & Laura Llorca

  2. Department of Preventive Medicine, Public Health and Microbiology, Medical School, Autonomous University of Madrid, Madrid, Spain

    Teresa Alarcón

  3. Department of Medicine and Microbiology, New York University Langone Medical Center, New York, NY, USA

    Guillermo Perez-Perez

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  1. Teresa Alarcón
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  2. Laura Llorca
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  3. Guillermo Perez-Perez
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Correspondence to Guillermo Perez-Perez .

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  1. Division of Microbiology, Department of Biology, Friedrich Alexander University Erlangen/Nuremberg, Erlangen, Germany

    Nicole Tegtmeyer

  2. Divisioin of Microbiology, Department of Biology, Friedrich Alexander University Erlangen/Nuremberg, Erlangen, Germany

    Steffen Backert

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Alarcón, T., Llorca, L., Perez-Perez, G. (2017). Impact of the Microbiota and Gastric Disease Development by Helicobacter pylori . In: Tegtmeyer, N., Backert, S. (eds) Molecular Pathogenesis and Signal Transduction by Helicobacter pylori. Current Topics in Microbiology and Immunology, vol 400. Springer, Cham. https://doi.org/10.1007/978-3-319-50520-6_11

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