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Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice

  • Kohji FukunagaEmail author
  • Shigeki Moriguchi
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 964)

Abstract

Sigma-1 receptor (Sig-1R) is molecular chaperone regulating calcium efflux from the neuronal endoplasmic reticulum to mitochondria. Recent studies show that Sig-1R stimulation antagonizes depressive-like behaviors in animal models, but molecular mechanisms underlying this effect remain unclear. Here, we focus on the effects of Sig-1R ligands on hippocampal neurogenesis and depressive-like behaviors. Sig-1R stimulation also enhances CaMKII /CaMKIV and protein kinase B (Akt) activities in hippocampus. Therefore, we discuss the fundamental roles of Sig-1R, CaMKII /CaMKIV and protein kinase B (Akt) signaling in amelioration of depressive-like behaviors following Sig-1R stimulation.

Keywords

CaMKII CaMKIV BDNF Neurogenesis Depression Sigma-1 receptor 

Abbreviations

Akt

protein kinase B

BDNF

brain-derived neurotrophic factor

BrdU

bromodeoxyuridine

CaMKII

calcium/calmodulin-dependent protein kinase II

CaMKIV

calcium/calmodulin-dependent protein kinase IV

CREB

cAMP-responsive element binding protein

DG

dentate gyrus

DHEA

dehydroepiandrosterone

ER/SR

endoplasmic/sacroplasmic reticulum

ERK

extracellular signal-regulated kinase

LTP

long-term potentiation

NMDAR

N-methyl-D-aspartate receptor

SERCA

sarcoplasmic/endoplasmic Ca2+-ATPase

Sig-1R

sigma-1 receptor

SSRIs

selective serotonin reuptake inhibitors

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Copyright information

© Springer International Publishing AG (outside the USA) 2017

Authors and Affiliations

  1. 1.Department of Pharmacology, Graduate School of Pharmaceutical SciencesTohoku UniversitySendaiJapan

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