Surgical Management of Epilepsy

  • Patti L. Batchelder


Epilepsy is the most common neurologic disorder of childhood, affecting 1 in every 100 children. This chapter discusses the different types of epilepsy, surgical management, and selection criteria for surgical patients. Preoperative preparation and postoperative nursing considerations, including nursing care in the epilepsy monitoring unit (EMU), are also addressed. The importance of a multidisciplinary team approach is emphasized, particularly nursing’s role as communicator and family advocate. Quality of life outcomes with a patient case study illustrate the goals of surgical management.


Tuberous Sclerosis Complex Seizure Onset Epilepsy Surgery Intractable Epilepsy Cortical Dysplasia 
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Video 13.1

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  1. Aldenkamp A, Besag F, Gobbi G, Caplan R, Dunn D, Sillanpaa (2016) Psychiatric and behavioral disorders in children with epilepsy (ILAE Task Force Report): adverse cognitive and behavioural effects of antiepileptic drugs in children. Epileptic Disord 18(supplement):555–567Google Scholar
  2. Alonso F, Sweet J, Miller J (2016) Speech mapping using depth electrodes: the “electric wada”. Clin Neurol Neurosurg 144:88–90PubMedCrossRefGoogle Scholar
  3. Asano E, Brown EC, Csaba J (2013) How to establish causality in epilepsy surgery. Brain Dev 35:706–720PubMedPubMedCentralCrossRefGoogle Scholar
  4. Beier AD, Rutka JT (2013) Hemispherectomy: historical review and recent technical advances. Neurosurg Focus 34:E11PubMedCrossRefGoogle Scholar
  5. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, vanEmde BW, Engel J, French J, Glauser TA, Mathern GW, Moshe SL, Nordli D, Plouin P (2010) Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology 2005–2009. Epilepsia 51:676–685PubMedCrossRefGoogle Scholar
  6. Berg AT, Zelko FA, Levy SR, Testa FM (2012) Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes. Neurology 79:1384–1388PubMedPubMedCentralCrossRefGoogle Scholar
  7. Bien CG, Granata T, Antozzi C, Cross JH Dulac O, Kurthen M, Lassman H, Mantegazza R, Villemure JG, Spreafico R, Elger CE (2005) Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement. 128(3):454–471Google Scholar
  8. Blumcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G, Barkovich AJ, Battaglia G, Becker A, Cepeda C, Cendes F, Colombo N, Crino P, Cross JH, Delalande O, Dubeau F, Duncan J, Guerrini R, Kahane P, Mathern G, Najm I, Ozkara C, Raybaud C, Represa A, Roper SN, Salamon N, Schulze-Bonhage A, Tassi L, Vessani A, Spreafico R (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia 52:158–174PubMedCrossRefGoogle Scholar
  9. Bodin E, Le Moing AG, Bourel-Ponchel E, Quere L, Toussaint P, Berquin P (2016) Vagus nerve stimulation in the treatment of drug-resistant epilepsy in 29 children. Eur J Pediatr Neurol 20:346–351CrossRefGoogle Scholar
  10. Bower RS, Wirrell EC, Eckel LJ, Wong-Kisiel LC, Nickels KC, Wetjen NM (2015) Repeat resective surgery in complex pediatric refractory epilepsy: lessons learned. J Neurosurg Pediatr 16:94–100PubMedCrossRefGoogle Scholar
  11. Brodie MJ, Barry SJ, Bamagous GA, Kwan P (2013) Effect of doasage failed of first antiepileptic drug on subsequent outcome. Epilepsia 54:194–198PubMedCrossRefGoogle Scholar
  12. Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O’Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE (2013) Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia 54(suppl 4):44–60PubMedPubMedCentralCrossRefGoogle Scholar
  13. Comi A (2015) Current therapeutic options in Sturge-Weber syndrome. Semin Pediatr Neurol 22:295–301PubMedPubMedCentralCrossRefGoogle Scholar
  14. Comi AM, Sahin M, Hammill A, Kaplan EH, Juhasz C, North P, Ball KL, Levin AV, Cohen B, Morris J, Lo W, Roach ES (2016) 2015 Sturge-Weber syndrome research workshop. Pediatr Neurol 58:12–24PubMedCrossRefGoogle Scholar
  15. Connolly MB, Hendson G, Steinbok P (2006) Tuberous sclerosis complex: a review of the management of epilepsy with emphasis on surgical aspects. Childs Nerv Syst 22:896–908PubMedCrossRefGoogle Scholar
  16. Cross JH, Jayakar P, Nordli D, Delalande O, Duchowny M, Wieser HG, Guerrini R, Mathern G (2006) Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission of Pediatric Epilepsy Surgery. Epilepsia 47:952–959PubMedCrossRefGoogle Scholar
  17. Curatolo P, Moavero R, Roberto D, Graziola F (2015) Genotype/phenotype correlations in tuberous sclerosis complex. Semin Pediatr Neurol 22:259–273PubMedCrossRefGoogle Scholar
  18. Curatolo P, Aronica E, Jansen A, Jansen F, Kotulska K, Lagae L, Moavero R, Jozwiak S (2016) Early onset epileptic encephalopathy or genetically determined encephalopathy with early onset epilepsy? Eur J Pediatr Neurol 20:203–211CrossRefGoogle Scholar
  19. Deleo F, Garbelli R, Milesi G, Gozzo F, Bramerio M, Villani F, Cardinale F, Trinagali G, Spreafico R, Tassi L (2016) Short-and long-term surgical outcomes of temporal lobe epilepsy associated with hippocampal sclerosis: relationships with neuropathology. Epilepsia 57:306–315PubMedCrossRefGoogle Scholar
  20. Di Rocco C, Tamburrini G (2006) Sturge-Weber syndrome. Childs Nerv Syst 22:909–921PubMedCrossRefGoogle Scholar
  21. Diaz RJ, Sherman EMS, Hader WJ (2008) Surgical treatment of intractable epilepsy associated with focal cortical dysplasia. Neurosurg Focus 25:E6PubMedCrossRefGoogle Scholar
  22. Dubeau F (2011) Rasmussen encephalitis (chronic focal encephalitis). In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  23. Durnford AJ, Rodgers W, Kirkham FJ, Mullee MA, Whitney A, Previtt M, Kinton L, Harris M, Gray WP (2011) Very good inter-rater reliability of Engel and ILAE epilepsy surgery outcome classifications in a series of 76 patients. Seizure. doi: 10.1016/j.seizure.2011.08.004 PubMedGoogle Scholar
  24. Dym RJ, Burns J, Lipton ML (2011) Is functional MR imaging assessment of hemispheric language dominance as good as WADA test? Radiology 261:446–455PubMedCrossRefGoogle Scholar
  25. El Tahry R, Hirsch M, Van Rijckevorsel K, Santos SF, de Tourtchaninoff M, Rooijakkers H, Coenen V, Schulze-Bonhage A (2016) Early experiences with tachycardia-triggered vagus nerve stimulation using the AspireSR stimulator. Epileptic Disord 18:155–162PubMedGoogle Scholar
  26. Engel JJ (2013) Why is there still doubt to cut it out? Epilepsy Curr 13:198–204PubMedPubMedCentralCrossRefGoogle Scholar
  27. Engel JJ, Van Ness PC, Rasmussen TB, Ojemann LM (1993) Outcome with respect to epileptic seizures. In: Engel JJ (ed) Surgical treatment of the epilepsies, 2nd edn. Raven Press, New York, pp 609–621Google Scholar
  28. Englot DJ, Breshears JK, Sun PP, Chang EF, Auguste KI (2013) Seizure outcomes after resective surgery for extra-temporal lobe epilepsy in pediatric patients. J Neurosurg Pediatr 12:126–133PubMedCrossRefGoogle Scholar
  29. Englot DJ, Rolston JD, Wang DD, Sun PP, Chang EF, Auguste KI (2013) Seizure outcomes after temporal lobectomy in pediatric patients: a systematic review. J Neurosurg Pediatr 12:134–141PubMedCrossRefGoogle Scholar
  30. Englot DJ, Seunggu JH, Rolston JD, Ivan ME, Kuperman RA, Chang EF, Gupta N, Sullivan JE, Auguste KI (2014) Epilepsy surgery failure in children: a quantitative and qualitative analysis. J Neurosurg Pediatr 14:386–395PubMedPubMedCentralCrossRefGoogle Scholar
  31. Englot DJ, Nagarajan SS, Imber BS, Raygor KP, Honma SM, Mizuiri D, Mantle M, Knowlton RC, Kirsch HE, Chang EF (2015) Epileptogenic zone localization using magnetoencephalography predicts seizure freedom in epilepsy surgery. Epilepsia 56:949–958PubMedPubMedCentralCrossRefGoogle Scholar
  32. Englot DJ, Harjus B, Chang EF (2016) Seizure outcomes in nonresective epilepsy surgery: an update.Google Scholar
  33. Fallah A, Rodgers SD, Weil AG, Vadera S, Monsouri A, Connolly MB, Major P, Ma T, Devinsky O, Weiner HL, Gonzalez-Martinez JA, Bingaman WE, Najm I, Gupta A, Ragheb J, Bhatia S, Steinbok P, Witiw CD, Widjaja E, Snead OC, Rutka JT (2015) Resective epilepsy surgery for tuberous sclerosis in children: determining predictors of seizure outcomes in a multicenter retrospective cohort study. Neurosurgery 77:517–524PubMedCrossRefGoogle Scholar
  34. Farwell JR, Dodrill CB, Batzel LW (1985) Neuropsychological abilities of children with epilepsy. Epilepsia 26:395–400PubMedCrossRefGoogle Scholar
  35. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel JJ, Forsgren L, French JA, Glynn M, Hesdorffer C, Lee BI, Mathern GW, Moshe SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S (2014) A practical clinical definition of epilepsy. Epilepsia 55:475–482PubMedCrossRefGoogle Scholar
  36. Go C, Snead OC (2008) Pharmacologically intractable epilepsy in children: diagnosis and preoperative evaluation. Neurosurg Focus 25(E2):1–7Google Scholar
  37. Gonzalez-Martinez J, Bulacio J, Alexopoulos A, Jehi L, Bingaman W, Najm I (2013) Stereoencephalography in the “difficult to localize” refractory focal epilepsy: early experience from a North American epilepsy center. Epilepsia 54:323–330PubMedCrossRefGoogle Scholar
  38. Gonzalez-Martinez J, Mullin J, Bulacio J, Gupta A, Enatsu R, Najm I, Bingaman W, Wyllie E, Lachhwani D (2014) Stereoelectroencephalography in children and adolescents with difficult to localize refractory focal epilepsy. Neurosurgery 75:258–267PubMedCrossRefGoogle Scholar
  39. Graham D, Tisdall MM, Gill D (2016) Corpus callosotomy outcomes in pediatric patients: a systematic review. Epilepsia 57:1053–1068PubMedCrossRefGoogle Scholar
  40. Guan J, Karsy M, Ducis K, Bollo R (2016) Surgical strategies for pediatric epilepsy. Transl Pediatr 5:55–66PubMedPubMedCentralCrossRefGoogle Scholar
  41. Gupta A (2011) Epilepsy in the setting of neurocutaneous syndromes. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  42. Hao X, Wong ISM, Kwan P (2011) Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study. Epilepsy Behav 22:388–390PubMedCrossRefGoogle Scholar
  43. Harvey S, Cross JH, Shinnar S, Mathern BW, ILAE Pediatric Epilepsy Surgery Survey Taskforce (2008) Defining the spectrum of international practice in pediatric epilepsy surgery patients. Epilepsia 49:146–155PubMedCrossRefGoogle Scholar
  44. Hirfanoglu T, Serdaroglu A, Cansu A, Bilir E, Gucleyener K (2006) Semiological seizure classification: before and after video-EEG monitoring of seizures. Pediatr Neurol 36:231–235CrossRefGoogle Scholar
  45. Hoffman CE, Ochi A, Snead BC, Widjaja E, Hawkins C, Tisdal M, Rutka JT (2016) Rasmussen’s encephalitis: advances in management and outcomes. Childs Nerv Syst 32:629–640PubMedCrossRefGoogle Scholar
  46. Holmes G (2002) Epilepsy surgery in children: when, why, and how. Neurology 58(suppl 7):S13–S20PubMedCrossRefGoogle Scholar
  47. Jalilian L, Limbrick DD, Steger-May K, Johnston J, Powers AK, Smyth MD (2010) Complete versus two-thirds corpus callosotomy in children: analysis of outcome. J Neurosurg Pediatr 6:257–266PubMedCrossRefGoogle Scholar
  48. Jehi L, Martinez-Gonzalez J, Bingaman W (2011) Outcome and complications of epilepsy surgery. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  49. Jenny B, Smoll N, Hassani YE, Momkian S, Pollo C, Korff CM, Seeck M, Schaller K (2016) Pediatric epilepsy surgery: could age be a predictor of outcomes? J Neurosurg Pediatr 29:1–7Google Scholar
  50. Jette N, Wiebe S (2016) Initial evaluation of the patient with suspected epilepsy. Neurol Clinics 34:339–350CrossRefGoogle Scholar
  51. Johnston JM, Mangano FT, Ojemann JG, Park TS, Trevathan E, Smyth M (2006) Complications of invasive subdural electrode monitoring at St. Louis Children’s Hospital 1994–2005. J Neurosurg 105(5 Suppl):343–347PubMedGoogle Scholar
  52. Kabir SMR, Rajaraman C, Ritty C, Zaki HS, Kemeny AA, McMullan J (2009) Vagus nerve stimulation in children with intractable epilepsy: indications, complications, and outcome. Childs Nerv Syst 25:1097–1100PubMedCrossRefGoogle Scholar
  53. Karsy M, Guan J, Ducis K, Bollo RJ (2016) Emerging surgical therapies in the treatment of pediatric epilepsy. Transl Pediatr 5:67–78PubMedPubMedCentralCrossRefGoogle Scholar
  54. Kellinghaus C, Luders HO (2011) Classification of seizures. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  55. Kim EH, Ko TS (2016) Cognitive impairment in childhood onset epilepsy: up-to-date information about its cause. Kor J Pediatr 59:155–164CrossRefGoogle Scholar
  56. Kim KJ, Lee R, Chae JH, Hwang YS (2002) Application of semiological seizure classification to epileptic seizures in children. Seizure 11:281–284PubMedCrossRefGoogle Scholar
  57. Kunieda T, Mikuni N, Shibata S, Inano R, Yamao Y, Kikuchi T, Matsumoto R, Takahashi J, Ikeda A, Fukuyama H, Miyamoto S (2013) Long-term seizure outcome following resective surgery for epilepsy: to be or not to be completely cured? Neurol Med Chir (Tokyo) 53:805–813CrossRefGoogle Scholar
  58. Kwan P, Brodie M (2000) Early identification of refractory epilepsy. N Engl J Med 342:314–319PubMedCrossRefGoogle Scholar
  59. Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Hauser WA, Mathern G, Moshe SL, Perucca E, Wiebe S, French J (2010) Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilespia 51:1069–1077CrossRefGoogle Scholar
  60. Lee J, Adelson P (2004) Neurosurgical management of pediatric epilepsy. Pediatr Clin N Am 51:441–456CrossRefGoogle Scholar
  61. Lee YJ, Kang HC, Kim HD, Kim DS, Shim KW, Ma SE, Lee JS (2015) Neurocognitive function in children after anterior temporal lobectomy with amygdalohippocampectomy. Pediatr Neurol 52:88–93PubMedCrossRefGoogle Scholar
  62. Lewis EC, Weil AG, Duchowny M, Bhatia S, Ragheb J, Miller I (2015) MR-guided laster interstitial thermal therapy for pediatric drug-resistant lesional epilepsy. Epilepsia 56:1590–1598PubMedCrossRefGoogle Scholar
  63. Limbrick DD, Narayan P, Powers AK, Ojemann JG, Park TS, Bertrand M, Smyth MD (2011) Hemispherotomy: efficacy and analysis of seizure recurrence. J Neurosurg Pediatr 4:323–332CrossRefGoogle Scholar
  64. Linehan C, Berg AT (2011) Epidemiologic aspects of epilepsy. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  65. Loddenkemper T (2011) Classification of the epilepsies. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  66. Luders HO, Acharya J, Baumgartner C et al (1998) Semiological seizure classification. Epilepsia 39:1006–1013PubMedCrossRefGoogle Scholar
  67. Maguire MJ, Jackson CF, Marson AG, Nolan SJ (2016) Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). Cochrane Database Syst Rev (7):CD011792Google Scholar
  68. Malmgren K, Rydenhag B, Hallbook T (2015) Reappraisal of corpus callosotomy. Curr Opin Neurol 28:175–181PubMedCrossRefGoogle Scholar
  69. Mapstone TB (2008) Vagus nerve stimulation: current concepts. Neurosurg Focus 25(E9):1–4Google Scholar
  70. Meador KJ (2011) Cognitive effects of epilepsy and antiepileptic medications. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  71. Mikati MA, Ataya N, Ferzli J, Kurdi R, El-Banna D, Rahi A, Shamseddine A, Sinno D, Comair Y (2010) Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls. Epilepsy Res 90:207–213PubMedCrossRefGoogle Scholar
  72. Moosa A, Jehi L, Marashly A, Cosmo G, Lachhwani D, Wylie E, Kotagoal P, Bingaman W, Gupta A (2013) Long-term functional outcome and their predictors after hemispherectomy in 115 children. Epilepsia 54:1771–1779PubMedCrossRefGoogle Scholar
  73. Mullin JP, Sexton D, Al-Omar S, Bingaman W, Gonzalez-Martinez J (2016a) Outcomes of subdural grid electrode monitoring in the stereoencephalography era. World Neurosurg 89:255–258PubMedCrossRefGoogle Scholar
  74. Mullin JP, Shriver M, Alomar S, Najm I, Bulacio J, Chauvel P, Gonzalez-Martinez J (2016b) Is SEEG safe? A systematic review and meta-analysis of stereo-electroencephalography-related complications. Epilepsia 57:386–401PubMedCrossRefGoogle Scholar
  75. Neal EG, Chagge H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, Whitney A, Cross JH (2008) The ketogenic diet for the treatment of childhood epilepsy: a randomized control trial. Lancet Neurol 7:500–506PubMedCrossRefGoogle Scholar
  76. Neubauer BA, Hahn A, Tuxhorn I (2011) Progressive and infantile myoclonic epilepsies. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  77. Nissen IA, Stam CJ, Citroen J, Reijneveld JC, Hillebrand A (2016) Preoperative evaluation using magnetoencephalography: experience in 382 epilepsy patients. Epilepsy Res 124:23–33PubMedCrossRefGoogle Scholar
  78. Nordli DR, De Vivo DC (2011) The ketogenic diet. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  79. Panayiotopoulos CP (2012) The new ILAE report on terminology and concepts for the organization of epilepsies: critical review and contribution. Epilepsia 53:399–404PubMedCrossRefGoogle Scholar
  80. Parr J, Augustijn PB, Geerts Y, vanEmde BW (2001) Classification of epileptic seizures: a comparison of two systems. Epilepsia 42:476–482CrossRefGoogle Scholar
  81. Phi JH, Cho BK, Wang KC, Lee JY, Hwang YS, Kim KJ, Chae JH, Kim IO, Park SH, Kim SK (2010) Longitudinal analyses of the surgical outcomes of pediatric epilepsy patients with focal cortical dysplasia. J Neurosurg Pediatr 6:49–56PubMedCrossRefGoogle Scholar
  82. Pittau F, Grouiller F, Spinelli L, Seeck M, Michel CM, Vulliemoz S (2014) The role of functional neuroimaging in pre-surgical epilepsy evaluation. Front Neurol 5:1–16Google Scholar
  83. Puka K, Smith ML (2015) Predictors of long-term quality of life after pediatric epilepsy surgery. Epilepsia 56:873–881PubMedCrossRefGoogle Scholar
  84. Ramey WL, Martirosyan NL, Lieu CM, Hasham HA, Lemole GM, Weinand ME (2013) Current management and surgical outcomes of medically intractable epilepsy. Clin Neurol Neurosurg 115:2411–2418PubMedCrossRefGoogle Scholar
  85. Revesz D, Rydenhag B, Ben-Menachem E (2016) Complications and safety of vagus nerve stimulation: 25 years of experience at a single center. J Neurosurg Pediatr 18:97–104PubMedCrossRefGoogle Scholar
  86. Rolston JD, Chang EF (2016) Stereotactic laser ablation for hypothalamic hamartoma. Neurosurg Clin N Am 27:59–67PubMedCrossRefGoogle Scholar
  87. Rowland NC, Englot DJ, Cage TA, Sughrue E, Barbaro NM, Chang EF (2012) A meta-analysis of predictors of seizure freedom in surgical management of focal cortical dysplasia. J Neurosurg 116:1035–1041PubMedCrossRefGoogle Scholar
  88. Ryvlin P, Rheims S (2016) Predicting epilepsy surgery outcome. Curr Opin Neurol 29:182–188PubMedCrossRefGoogle Scholar
  89. Rzezak P, Valente KD, Duchowny MS (2014) Temporal lobe epilepsy in children: executive and mnestic impairments. Epilepsy Behav 31:117PubMedCrossRefGoogle Scholar
  90. Sanchez F, An S, Loddenkemper T (2015) Pediatric refractory epilepsy: a decision analysis comparing medical versus surgical treatment. Epilepsia 56:263–272CrossRefGoogle Scholar
  91. Schevon CA, Carlson C, Zaroff C, Weiner HJ, Doyle WK, Miles D, Lajoie J, Kuzniecky R, Pacia S, Vazquez B, Luciano D, Najjar S, Devinsky O (2007) Pediatric language mapping: sensitivity of neurostimulation and WADA testing in epilepsy surgery. Epilepsia 48:539–545PubMedCrossRefGoogle Scholar
  92. Schramm J, Kuczaty S, Sassen R, Elger CE, von Lehe M (2012) Pediatric functional hemispherectomy: outcome in 92 patients. Acta Neurochir (Wien) 154:2017–2028CrossRefGoogle Scholar
  93. Schuele SU, Luders HO (2008) Intractable epilepsy: management and therapeutic alternatives. Lancet Neurol 7:514–524PubMedCrossRefGoogle Scholar
  94. Seneviratne U (2016) Sudden unexpected death in epilepsy: a silent killer. Ceylon Med J 61(2):47–51PubMedCrossRefGoogle Scholar
  95. Serdaroglu A, Arhan E, Kurt G, Erdem A, Hirfanoglu T, Aydin K, Bilir E (2016) Long term effect of vagus nerve stimulation in pediatric intractable epilepsy: an extended follow-up. Childs Nerv Syst 32:641–646PubMedCrossRefGoogle Scholar
  96. Shurtleff HA, Barry D, Firman T, Warner MH, Aguilar-Estrada RL, Saneto RP, Kuratani JD, Ellenbogen RG, Novotny EJ, Ojemann JG (2015) Impact of epilepsy surgery on development of preschool children: identification of a cohort likely to benefit from early intervention. J Neurosurg Pediatr 16:383–339PubMedCrossRefGoogle Scholar
  97. Sood S, Marupudi NI, Asano E, Haridas A, Ham SD (2015) Endoscopic corpus callosotomy and hemispherectomy. J Neurosurg Pediatr 16:681–686PubMedCrossRefGoogle Scholar
  98. Sudarsanam A, Arden-Holmes SL (2014) Sturge-Weber syndrome: from the past to the present. Eur J Pediatr Neurol 18:257–266CrossRefGoogle Scholar
  99. Tatum WO (2011) Atypical absence seizures, myoclonic, tonic, and atonic seizures. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  100. Tellez-Zenteno JF, Ronquillo LH, Moien-Afshari F, Wiebe S (2010) Surgical outcomes in lesional and non-lesional epilepsy: a systematic review and meta-analysis. Epilepsy Res 89:310–318PubMedCrossRefGoogle Scholar
  101. Tovar-Spinoza Z, Carter D, Ferrone D, Eksioglu Y, Huckins S (2013) The use of MRI-guided laser-induced thermal ablation for epilepsy. Childs Nerv Syst 29:2089–2094PubMedCrossRefGoogle Scholar
  102. Tsur VG, O’Dell C, Shinnar S (2011) Initiation and discontinuation of antiepileptic drugs. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5ths edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  103. Vadera S, Mullin J, Bulacio J, Najm I, Bingaman W, Gonzalez-Martinez J (2013) Stereoelectroencephalography following subdural grid placement in difficult to localize epilepsy. Neurosurgery 72:723–728PubMedCrossRefGoogle Scholar
  104. Vadera S, Griffith SD, Rosenbaum BP, Seicean A, Kshettry ML, Weil RJ, Bingaman W, Jehi L (2015) National trends and in-hospital complication rates in more than 1600 hemispherectomies from 1988 to 2010: a nationwide inpatient sample study. Neurosurgery 77:185–191PubMedCrossRefGoogle Scholar
  105. Varadkar S, Bien CG, Kruse CA, Jensen FE, Bauer J, Pardo CA, Vincent A, Mathem GW, Cross JH (2014) Rasmussen’s encephalitis: clinical features, pathobiology, and treatment advances. Lancet Neurology13(2):195–205Google Scholar
  106. Velasco TR, Mather GW (2011) Surgical treatment of refractory temporal lobe epilepsy. In: Wyllie E (ed) Wyllie’s treatment of epilepsy: principles and practice, 5th edn. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  107. Vendrame M, Loddenkemper T (2010) Surgical treatment of refractory status epilepticus in children: candidate selection and outcome. Semin Pediatr Neurol 17:182–189PubMedCrossRefGoogle Scholar
  108. Wasade VS, Elisevich K, Tahir R, Smith B, Schultz L, Schwalb J, Spanaki-Varelas M (2015) Long-term seizure and psychosocial outcomes after resective surgery for intractable epilepsy. Epilepsy Behav 43:122–127PubMedCrossRefGoogle Scholar
  109. Weiser HG, Blume WT, Fish D, Goldensohn E, Hufnagel A, King D, Sperling MR, Luders H (2001) ILAE commission report: proposal for a new classification of outcome with respect to epileptic seizures following epilepsy surgery. Epilepsia 42:282–286CrossRefGoogle Scholar
  110. West S, Nolan SJ, Newton R (2016) Surgery for epilepsy: a systematic review of current evidence. Epileptic Disord 18:113–120PubMedGoogle Scholar
  111. Widjaja E, Raybaud C (2008) Advances in neuroimaging in patients with epilepsy. Neurosurg Focus 25(E3):1–11Google Scholar
  112. Yang PF, Zhang HJ, Pei JS, Tian J, Lin Q, Mei Z, Zhong ZH, Jia YZ, Chen ZQ, Zheng ZY (2014) Intracranial electroencephalography with subdural and/or depth electrodes in children with epilepsy: techniques, complications, and outcomes. Epilepsy Res 108:1662–1670PubMedCrossRefGoogle Scholar
  113. Zupanc ML, dos Santos Rubio EJ, Werner RR, Schwabe MJ, Mueller WM, Lew SM, Marcuccilli CJ, O’Connor SE, Chico MS, Eggener KA, Hecox KE (2010) Epilepsy surgery outcomes: quality of life and seizure control. Pediatr Neurol 42:12–20PubMedCrossRefGoogle Scholar

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© Springer International Publishing AG 2017

Authors and Affiliations

  • Patti L. Batchelder
    • 1
  1. 1.Department of NeurosurgeryChildren’s Hospital Colorado, University of Colorado School of MedicineAuroraUSA

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