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Outcome of Critically Ill Allogeneic Hematopoietic Stem-Cell Transplantation Recipients

  • Darius Seidler
  • Alex H. GiffordEmail author
Chapter

Abstract

Allogeneic hematopoietic stem cell transplant (HSCT) has become a standard treatment modality for hematological malignancies. Chemotherapy toxicity, infection, and syndromes associated with the graft and host interaction frequently jeopardize the health of these patients so significantly that they require admission to the intensive care unit (ICU). Despite improvements in the delivery of critical care services to allogeneic HSCT patients, ICU mortality rates remain high. Certain complications, particularly those involving the respiratory system, are strongly influenced by the length of time that has elapsed since transplant. Most allogeneic HSCT patients should receive critical care services, contrary to a widely held belief that excessive ICU-related morbidity and mortality preclude any meaningful chance of recovery.

Keywords

Allogeneic hematopoietic stem cell transplant Mortality Complications Critical illness 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Section of Pulmonary and Critical Care MedicineDartmouth-Hitchcock Medical CenterLebanonUSA

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