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Clinical Indices for Pediatric Inflammatory Bowel Disease Research

  • Dan TurnerEmail author
  • Oren Ledder
Chapter

Abstract

There is a large array of measurable parameters in inflammatory bowel disease (IBD), including symptoms and signs as well as endoscopic, serologic, and radiological findings. Therefore, generation of standardized multi-item outcome measure which accurately reflects disease state and response to interventions is critical for clinical research. Multiple instruments have been developed to assess various concepts of IBD both in Crohn’s disease and ulcerative colitis (UC) including clinical disease activity; patient-reported signs and symptoms; endoscopic, radiographic, and histologic appearance; and quality of life. These need to be modified, or often newly constructed, to more accurately reflect specific issues in the pediatric population. To be considered accurate, these measures must be evaluated for validity, reliability, responsiveness, and feasibility. This chapter provides an overview of the main instruments used in research and clinical practice, with an emphasis on assessing the specific utility of each.

Keywords

Crohn’s disease Ulcerative colitis Inflammatory bowel disease Pediatric Clinical indices Clinical research Outcome measure Activity index Endoscopic measurement Patient-reported outcome Quality of life 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, The Hebrew University of Jerusalem, Shaare Zedek Medical CenterJerusalemIsrael

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