Differential Diagnosis of Inflammatory Bowel Disease

  • Thierry LamireauEmail author
  • Raphael Enaud


Numerous diseases can present with symptoms similar to IBD. In case of acute-onset diarrhea, infectious or allergic diseases and acute appendicitis should be ruled out before considering the diagnosis of IBD. Chronic or recurrent intestinal symptoms are more suggestive of IBD. Infection, celiac disease, or food allergy should all be entertained in the differential diagnosis in this situation. Neoplasm and vasculitic disorders are more rarely involved. Disorders of the immune system should be sought after, especially in cases of early-onset (<6 years) symptoms, as numerous monogenic disorders are currently being discovered with specific therapeutic options available. Less classic presentations of IBD can be encountered, leading to consideration of other diagnoses such as tumors or tuberculosis in cases of an abdominal mass, peptic disease in cases of isolated esophagogastroduodenal involvement, immunodeficiency syndromes, or trauma in cases of isolated perianal/perineal disease.


Inflammatory bowel disease Diagnosis Infection Allergy Immunodeficiency Perianal disease 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Unit of Pediatric Gastroenterology and Nutrition, Children’s HospitalBordeauxFrance

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