Complications of Upper Endoscopy and Their Management

  • C. Andrew Kistler
  • Aaron Martin
  • Jeremy Kaplan
  • Joseph Yoo
  • Ali A. SiddiquiEmail author


Esophagoduodenoscopy (EGD) is one of the most frequently utilized procedures by gastroenterologists. Although upper endoscopy is considered one of the safest gastroenterology procedures, it is still associated with complications (1 in 200–10,000). Major adverse events related to upper endoscopy are rare and include cardiopulmonary adverse events, infection, perforation, and bleeding. As endoscopy assumes a more therapeutic role in the management of GI disorders, the potential for adverse events will increase. It is vital that the endoscopist has knowledge of potential endoscopic adverse events, what their frequency is, and the risk factors for their occurrence. Endoscopists need to select patients for the appropriate intervention and be prepared to manage any adverse events that may arise. Once an adverse event occurs, early recognition and prompt intervention may minimize the morbidity and mortality associated with that adverse event.


Upper endoscopy Adverse events Bleeding Infection Perforation 

Supplementary material

This video demonstrated the control of hemostasis with endoscopic hemoclips due to biopsy of an antral submucosal mass after unroofing of this lesion (MP4 58416 kb)


  1. 1.
    Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–87 (e1–3).Google Scholar
  2. 2.
    Committee ASoP, Ben-Menachem T, Decker GA, Early DS, Evans J, Fanelli RD, et al. Adverse events of upper GI endoscopy. Gastrointest Endosc. 2012;76(4):707–18.Google Scholar
  3. 3.
    Park WG, Shaheen NJ, Cohen J, Pike IM, Adler DG, Inadomi JM, et al. Quality indicators for EGD. Am J Gastroenterol. 2015;110(1):60–71.PubMedCrossRefGoogle Scholar
  4. 4.
    Silvis SE, Nebel O, Rogers G, Sugawa C, Mandelstam P. Endoscopic complications. Results of the 1974 American Society for gastrointestinal endoscopy survey. JAMA. 1976;235(9):928–30.PubMedCrossRefGoogle Scholar
  5. 5.
    Wolfsen HC, Hemminger LL, Achem SR, Loeb DS, Stark ME, Bouras EP, et al. Complications of endoscopy of the upper gastrointestinal tract: a single-center experience. Mayo Clin Proc. 2004;79(10):1264–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Zubarik R, Eisen G, Mastropietro C, Lopez J, Carroll J, Benjamin S, et al. Prospective analysis of complications 30 days after outpatient upper endoscopy. Am J Gastroenterol. 1999;94(6):1539–45.PubMedGoogle Scholar
  7. 7.
    Sharma VK, Nguyen CC, Crowell MD, Lieberman DA, de Garmo P, Fleischer DE. A national study of cardiopulmonary unplanned events after GI endoscopy. Gastrointest Endosc. 2007;66(1):27–34.PubMedCrossRefGoogle Scholar
  8. 8.
    Quine MA, Bell GD, McCloy RF, Charlton JE, Devlin HB, Hopkins A. Prospective audit of upper gastrointestinal endoscopy in two regions of England: safety, staffing, and sedation methods. Gut. 1995;36(3):462–7.PubMedPubMedCentralCrossRefGoogle Scholar
  9. 9.
    Sieg A, Hachmoeller-Eisenbach U, Eisenbach T. Prospective evaluation of complications in outpatient GI endoscopy: a survey among German gastroenterologists. Gastrointest Endosc. 2001;53(6):620–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Froehlich F, Gonvers JJ, Fried M. Conscious sedation, clinically relevant complications and monitoring of endoscopy: results of a nationwide survey in Switzerland. Endoscopy. 1994;26(2):231–4.PubMedCrossRefGoogle Scholar
  11. 11.
    O’Connor HJ, Hamilton I, Lincoln C, Maxwell S, Axon AT. Bacteraemia with upper gastrointestinal endoscopy–a reappraisal. Endoscopy. 1983;15(1):21–3.PubMedCrossRefGoogle Scholar
  12. 12.
    Shull HJ Jr, Greene BM, Allen SD, Dunn GD, Schenker S. Bacteremia with upper gastrointestinal endoscopy. Ann Intern Med. 1975;83(2):212–4.PubMedCrossRefGoogle Scholar
  13. 13.
    Mellow MH, Lewis RJ. Endoscopy—related bacteremia. Incidence of positive blood cultures after endoscopy of upper gastrointestinal tract. Arch Intern Med. 1976;136(6):667–9.PubMedCrossRefGoogle Scholar
  14. 14.
    Baltch AL, Buhac I, Agrawal A, O’Connor P, Bram M, Malatino E. Bacteremia after upper gastrointestinal endoscopy. Arch Intern Med. 1977;137(5):594–7.PubMedCrossRefGoogle Scholar
  15. 15.
    Nelson DB. Infectious disease complications of GI endoscopy: Part I, endogenous infections. Gastrointest Endosc. 2003;57(4):546–56.PubMedCrossRefGoogle Scholar
  16. 16.
    Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116(15):1736–54.PubMedCrossRefGoogle Scholar
  17. 17.
    Asge Standards of Practice C, Banerjee S, Shen B, Baron TH, Nelson DB, Anderson MA, et al. Antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc. 2008;67(6):791–8.Google Scholar
  18. 18.
    Nelson DB. Infectious disease complications of GI endoscopy: Part II, exogenous infections. Gastrointest Endosc. 2003;57(6):695–711.PubMedCrossRefGoogle Scholar
  19. 19.
    Muscarella LF. Risk of transmission of carbapenem-resistant enterobacteriaceae and related “superbugs” during gastrointestinal endoscopy. World J Gastrointest Endosc. 2014;6(10):457–74.PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    ASGE Press Release: Transmission of CRE bacteria through endoscopic retrograde cholangiopancreatography (ERCP) [press release]. Feb 2015.Google Scholar
  21. 21.
    Penston JG, Boyd EJ, Wormsley KG. Mallory-Weiss tears occurring during endoscopy: a report of seven cases. Endoscopy. 1992;24(4):262–5.PubMedCrossRefGoogle Scholar
  22. 22.
    Montalvo RD, Lee M. Retrospective analysis of iatrogenic Mallory-Weiss tears occurring during upper gastrointestinal endoscopy. Hepatogastroenterology. 1996;43(7):174–7.PubMedGoogle Scholar
  23. 23.
    Chu DZ, Shivshanker K, Stroehlein JR, Nelson RS. Thrombocytopenia and gastrointestinal hemorrhage in the cancer patient: prevalence of unmasked lesions. Gastrointest Endosc. 1983;29(4):269–72.PubMedCrossRefGoogle Scholar
  24. 24.
    Abbas G, Schuchert MJ, Pettiford BL, Pennathur A, Landreneau J, Landreneau J, et al. Contemporaneous management of esophageal perforation. Surgery. 2009;146(4):749–55 (discussion 55–6).Google Scholar
  25. 25.
    Brinster CJ, Singhal S, Lee L, Marshall MB, Kaiser LR, Kucharczuk JC. Evolving options in the management of esophageal perforation. Ann Thorac Surg. 2004;77(4):1475–83.PubMedCrossRefGoogle Scholar
  26. 26.
    Hasimoto CN, Cataneo C, Eldib R, Thomazi R, Pereira RS, Minossi JG, et al. Efficacy of surgical versus conservative treatment in esophageal perforation: a systematic review of case series studies. Acta Cir Bras. 2013;28(4):266–71.PubMedCrossRefGoogle Scholar
  27. 27.
    Pettersson G, Larsson S, Gatzinsky P, Sudow G. Differentiated treatment of intrathoracic oesophageal perforations. Scand J Thorac Cardiovasc Surg. 1981;15(3):321–4.PubMedCrossRefGoogle Scholar
  28. 28.
    Larsen K, Skov Jensen B, Axelsen F. Perforation and rupture of the esophagus. Scand J Thorac Cardiovasc Surg. 1983;17(3):311–6.PubMedCrossRefGoogle Scholar
  29. 29.
    Panzini L, Burrell MI, Traube M. Instrumental esophageal perforation: chest film findings. Am J Gastroenterol. 1994;89(3):367–70.PubMedGoogle Scholar
  30. 30.
    Bladergroen MR, Lowe JE, Postlethwait RW. Diagnosis and recommended management of esophageal perforation and rupture. Ann Thorac Surg. 1986;42(3):235–9.PubMedCrossRefGoogle Scholar
  31. 31.
    Madanick RD. Medical management of iatrogenic esophageal perforations. Curr Treat Options Gastroenterol. 2008;11(1):54–63.PubMedCrossRefGoogle Scholar
  32. 32.
    Altorjay A, Kiss J, Voros A, Bohak A. Nonoperative management of esophageal perforations. Is it justified? Ann Surg. 1997;225(4):415–21.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Siersema PD, Homs MY, Haringsma J, Tilanus HW, Kuipers EJ. Use of large-diameter metallic stents to seal traumatic nonmalignant perforations of the esophagus. Gastrointest Endosc. 2003;58(3):356–61.PubMedCrossRefGoogle Scholar
  34. 34.
    Qadeer MA, Dumot JA, Vargo JJ, Lopez AR, Rice TW. Endoscopic clips for closing esophageal perforations: case report and pooled analysis. Gastrointest Endosc. 2007;66(3):605–11.PubMedCrossRefGoogle Scholar
  35. 35.
    van Heel NC, Haringsma J, Spaander MC, Bruno MJ, Kuipers EJ. Short-term esophageal stenting in the management of benign perforations. Am J Gastroenterol. 2010;105(7):1515–20.PubMedCrossRefGoogle Scholar
  36. 36.
    Richman DC. Ambulatory surgery: how much testing do we need? Anesthesiol Clin. 2010;28(2):185–97.PubMedCrossRefGoogle Scholar
  37. 37.
    Committee ASoP, Pasha SF, Acosta R, Chandrasekhara V, Chathadi KV, Eloubeidi MA, et al. Routine laboratory testing before endoscopic procedures. Gastrointest Endosc. 2014;80(1):28–33.Google Scholar
  38. 38.
    Lew RJ, Kochman ML. A review of endoscopic methods of esophageal dilation. J Clin Gastroenterol. 2002;35(2):117–26.PubMedCrossRefGoogle Scholar
  39. 39.
    Vogel SB, Rout WR, Martin TD, Abbitt PL. Esophageal perforation in adults: aggressive, conservative treatment lowers morbidity and mortality. Ann Surg. 2005;241(6):1016–21 (discussion 21–3).Google Scholar
  40. 40.
    Mandelstam P, Sugawa C, Silvis SE, Nebel OT, Rogers BH. Complications associated with esophagogastroduodenoscopy and with esophageal dilation. Gastrointest Endosc. 1976;23(1):16–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Pereira-Lima JC, Ramires RP, Zamin I Jr, Cassal AP, Marroni CA, Mattos AA. Endoscopic dilation of benign esophageal strictures: report on 1043 procedures. Am J Gastroenterol. 1999;94(6):1497–501.PubMedCrossRefGoogle Scholar
  42. 42.
    Hernandez LV, Jacobson JW, Harris MS. Comparison among the perforation rates of Maloney, balloon, and savary dilation of esophageal strictures. Gastrointest Endosc. 2000;51(4 Pt 1):460–2.PubMedCrossRefGoogle Scholar
  43. 43.
    Piotet E, Escher A, Monnier P. Esophageal and pharyngeal strictures: report on 1,862 endoscopic dilatations using the Savary-Gilliard technique. Eur Arch Otorhinolaryngol. 2008;265(3):357–64.PubMedCrossRefGoogle Scholar
  44. 44.
    Chuah SK, Hsu PI, Wu KL, Wu DC, Tai WC, Changchien CS. 2011 update on esophageal achalasia. World J Gastroenterol. 2012;18(14):1573–8.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Katzka DA, Castell DO. Review article: an analysis of the efficacy, perforation rates and methods used in pneumatic dilation for achalasia. Aliment Pharmacol Ther. 2011;34(8):832–9.PubMedCrossRefGoogle Scholar
  46. 46.
    Solt J, Bajor J, Szabo M, Horvath OP. Long-term results of balloon catheter dilation for benign gastric outlet stenosis. Endoscopy. 2003;35(6):490–5.PubMedCrossRefGoogle Scholar
  47. 47.
    Lau JY, Chung SC, Sung JJ, Chan AC, Ng EK, Suen RC, et al. Through-the-scope balloon dilation for pyloric stenosis: long-term results. Gastrointest Endosc. 1996;43(2 Pt 1):98–101.PubMedCrossRefGoogle Scholar
  48. 48.
    Kozarek RA, Botoman VA, Patterson DJ. Long-term follow-up in patients who have undergone balloon dilation for gastric outlet obstruction. Gastrointest Endosc. 1990;36(6):558–61.PubMedCrossRefGoogle Scholar
  49. 49.
    Rana SS, Bhasin DK, Chandail VS, Gupta R, Nada R, Kang M, et al. Endoscopic balloon dilatation without fluoroscopy for treating gastric outlet obstruction because of benign etiologies. Surg Endosc. 2011;25(5):1579–84.PubMedCrossRefGoogle Scholar
  50. 50.
    Lam YH, Lau JY, Fung TM, Ng EK, Wong SK, Sung JJ, et al. Endoscopic balloon dilation for benign gastric outlet obstruction with or without Helicobacter pylori infection. Gastrointest Endosc. 2004;60(2):229–33.PubMedCrossRefGoogle Scholar
  51. 51.
    Lin HH, Lee SC, Chu HC, Chang WK, Chao YC, Hsieh TY. Emergency endoscopic management of dietary foreign bodies in the esophagus. Am J Emerg Med. 2007;25(6):662–5.PubMedCrossRefGoogle Scholar
  52. 52.
    Ginsberg GG. Management of ingested foreign objects and food bolus impactions. Gastrointest Endosc. 1995;41(1):33–8.PubMedCrossRefGoogle Scholar
  53. 53.
    Webb WA. Management of foreign bodies of the upper gastrointestinal tract. Gastroenterology. 1988;94(1):204–16.PubMedCrossRefGoogle Scholar
  54. 54.
    Goh BK, Chow PK, Quah HM, Ong HS, Eu KW, Ooi LL, et al. Perforation of the gastrointestinal tract secondary to ingestion of foreign bodies. World J Surg. 2006;30(3):372–7.PubMedCrossRefGoogle Scholar
  55. 55.
    Webb WA. Management of foreign bodies of the upper gastrointestinal tract: update. Gastrointest Endosc. 1995;41(1):39–51.PubMedCrossRefGoogle Scholar
  56. 56.
    Mosca S, Manes G, Martino R, Amitrano L, Bottino V, Bove A, et al. Endoscopic management of foreign bodies in the upper gastrointestinal tract: report on a series of 414 adult patients. Endoscopy. 2001;33(8):692–6.PubMedCrossRefGoogle Scholar
  57. 57.
    Schwartz GF, Polsky HS. Ingested foreign bodies of the gastrointestinal tract. Am Surg. 1976;42(4):236–8.PubMedGoogle Scholar
  58. 58.
    Singh B, Kantu M, Har-El G, Lucente FE. Complications associated with 327 foreign bodies of the pharynx, larynx, and esophagus. Ann Otol Rhinol Laryngol. 1997;106(4):301–4.PubMedCrossRefGoogle Scholar
  59. 59.
    Athanassiadi K, Gerazounis M, Metaxas E, Kalantzi N. Management of esophageal foreign bodies: a retrospective review of 400 cases. Eur J Cardiothorac Surg. 2002;21(4):653–6.PubMedCrossRefGoogle Scholar
  60. 60.
    Al-Qudah A, Daradkeh S, Abu-Khalaf M. Esophageal foreign bodies. Eur J Cardiothorac Surg. 1998;13(5):494–8.PubMedCrossRefGoogle Scholar
  61. 61.
    Triadafilopoulos G, Roorda A, Akiyama J. Update on foreign bodies in the esophagus: diagnosis and management. Curr Gastroenterol Rep. 2013;15(4):317.PubMedCrossRefGoogle Scholar
  62. 62.
    Schmidt SC, Strauch S, Rosch T, Veltzke-Schlieker W, Jonas S, Pratschke J, et al. Management of esophageal perforations. Surg Endosc. 2010;24(11):2809–13.PubMedCrossRefGoogle Scholar
  63. 63.
    Gauderer MW, Ponsky JL, Izant RJ Jr. Gastrostomy without laparotomy: a percutaneous endoscopic technique. J Pediatr Surg. 1980;15(6):872–5.PubMedCrossRefGoogle Scholar
  64. 64.
    Rahnemai-Azar AA, Rahnemaiazar AA, Naghshizadian R, Kurtz A, Farkas DT. Percutaneous endoscopic gastrostomy: indications, technique, complications and management. World J Gastroenterol. 2014;20(24):7739–51.PubMedPubMedCentralCrossRefGoogle Scholar
  65. 65.
    McClave SA, Chang WK. Complications of enteral access. Gastrointest Endosc. 2003;58(5):739–51.PubMedCrossRefGoogle Scholar
  66. 66.
    Wollman B, D’Agostino HB, Walus-Wigle JR, Easter DW, Beale A. Radiologic, endoscopic, and surgical gastrostomy: an institutional evaluation and meta-analysis of the literature. Radiology. 1995;197(3):699–704.PubMedCrossRefGoogle Scholar
  67. 67.
    Hogan RB, DeMarco DC, Hamilton JK, Walker CO, Polter DE. Percutaneous endoscopic gastrostomy–to push or pull. A prospective randomized trial. Gastrointest Endosc. 1986;32(4):253–8.PubMedCrossRefGoogle Scholar
  68. 68.
    Kozarek RA, Ball TJ, Ryan JA Jr. When push comes to shove: a comparison between two methods of percutaneous endoscopic gastrostomy. Am J Gastroenterol. 1986;81(8):642–6.PubMedGoogle Scholar
  69. 69.
    Brown MC. Cancer metastasis at percutaneous endoscopic gastrostomy stomata is related to the hematogenous or lymphatic spread of circulating tumor cells. Am J Gastroenterol. 2000;95(11):3288–91.PubMedCrossRefGoogle Scholar
  70. 70.
    Jafri NS, Mahid SS, Minor KS, Idstein SR, Hornung CA, Galandiuk S. Meta-analysis: antibiotic prophylaxis to prevent peristomal infection following percutaneous endoscopic gastrostomy. Aliment Pharmacol Ther. 2007;25(6):647–56.PubMedCrossRefGoogle Scholar
  71. 71.
    Committee ASoP, Khashab MA, Chithadi KV, Acosta RD, Bruining DH, Chandrasekhara V, et al. Antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc. 2015;81(1):81–9.Google Scholar
  72. 72.
    Jain NK, Larson DE, Schroeder KW, Burton DD, Cannon KP, Thompson RL, et al. Antibiotic prophylaxis for percutaneous endoscopic gastrostomy. A prospective, randomized, double-blind clinical trial. Ann Intern Med. 1987;107(6):824–8.PubMedCrossRefGoogle Scholar
  73. 73.
    Sturgis TM, Yancy W, Cole JC, Proctor DD, Minhas BS, Marcuard SP. Antibiotic prophylaxis in percutaneous endoscopic gastrostomy. Am J Gastroenterol. 1996;91(11):2301–4.PubMedGoogle Scholar
  74. 74.
    Thomas S, Cantrill S, Waghorn DJ, McIntyre A. The role of screening and antibiotic prophylaxis in the prevention of percutaneous gastrostomy site infection caused by methicillin-resistant Staphylococcus aureus. Aliment Pharmacol Ther. 2007;25(5):593–7.PubMedCrossRefGoogle Scholar
  75. 75.
    Horiuchi A, Nakayama Y, Kajiyama M, Fujii H, Tanaka N. Nasopharyngeal decolonization of methicillin-resistant Staphylococcus aureus can reduce PEG peristomal wound infection. Am J Gastroenterol. 2006;101(2):274–7.PubMedCrossRefGoogle Scholar
  76. 76.
    Evans DA, Bhandarkar DS, Taylor TV. Necrotising fasciitis—a rare complication of percutaneous endoscopic gastrostomy. Endoscopy. 1995;27(8):627.PubMedCrossRefGoogle Scholar
  77. 77.
    Haas DW, Dharmaraja P, Morrison JG, Potts JR 3rd. Necrotizing fasciitis following percutaneous endoscopic gastrostomy. Gastrointest Endosc. 1988;34(6):487–8.PubMedCrossRefGoogle Scholar
  78. 78.
    Chung RS, Schertzer M. Pathogenesis of complications of percutaneous endoscopic gastrostomy. A lesson in surgical principles. Am Surg. 1990;56(3):134–7.PubMedGoogle Scholar
  79. 79.
    Cave DR, Robinson WR, Brotschi EA. Necrotizing fasciitis following percutaneous endoscopic gastrostomy. Gastrointest Endosc. 1986;32(4):294–6.PubMedCrossRefGoogle Scholar
  80. 80.
    Rino Y, Tokunaga M, Morinaga S, Onodera S, Tomiyama I, Imada T, et al. The buried bumper syndrome: an early complication of percutaneous endoscopic gastrostomy. Hepatogastroenterology. 2002;49(46):1183–4.PubMedGoogle Scholar
  81. 81.
    Sheers R, Chapman S. The buried bumper syndrome: a complication of percutaneous endoscopic gastrostomy. Gut. 1998;43(4):586.PubMedPubMedCentralCrossRefGoogle Scholar
  82. 82.
    Klein S, Heare BR, Soloway RD. The “buried bumper syndrome”: a complication of percutaneous endoscopic gastrostomy. Am J Gastroenterol. 1990;85(4):448–51.PubMedGoogle Scholar
  83. 83.
    Anagnostopoulos GK, Kostopoulos P, Arvanitidis DM. Buried bumper syndrome with a fatal outcome, presenting early as gastrointestinal bleeding after percutaneous endoscopic gastrostomy placement. J Postgrad Med. 2003;49(4):325–7.PubMedGoogle Scholar
  84. 84.
    Larson DE, Burton DD, Schroeder KW, DiMagno EP. Percutaneous endoscopic gastrostomy. Indications, success, complications, and mortality in 314 consecutive patients. Gastroenterology. 1987;93(1):48–52.PubMedCrossRefGoogle Scholar
  85. 85.
    Grant JP. Percutaneous endoscopic gastrostomy. Initial placement by single endoscopic technique and long-term follow-up. Ann Surg. 1993;217(2):168–74.PubMedPubMedCentralCrossRefGoogle Scholar
  86. 86.
    Safadi BY, Marks JM, Ponsky JL. Percutaneous endoscopic gastrostomy. Gastrointest Endosc Clin N Am. 1998;8(3):551–68.PubMedGoogle Scholar
  87. 87.
    Committee ASoP, Anderson MA, Ben-Menachem T, Gan SI, Appalaneni V, Banerjee S, et al. Management of antithrombotic agents for endoscopic procedures. Gastrointest Endosc. 2009;70(6):1060–70.Google Scholar
  88. 88.
    Ahmad J, Thomson S, McFall B, Scoffield J, Taylor M. Colonic injury following percutaneous endoscopic-guided gastrostomy insertion. BMJ Case Rep. 2010;2010.Google Scholar
  89. 89.
    Guloglu R, Taviloglu K, Alimoglu O. Colon injury following percutaneous endoscopic gastrostomy tube insertion. J Laparoendosc Adv Surg Tech A. 2003;13(1):69–72.PubMedCrossRefGoogle Scholar
  90. 90.
    Blum CA, Selander C, Ruddy JM, Leon S. The incidence and clinical significance of pneumoperitoneum after percutaneous endoscopic gastrostomy: a review of 722 cases. Am Surg. 2009;75(1):39–43.PubMedGoogle Scholar
  91. 91.
    Gottfried EB, Plumser AB, Clair MR. Pneumoperitoneum following percutaneous endoscopic gastrostomy. A prospective study. Gastrointest Endosc. 1986;32(6):397–9.PubMedCrossRefGoogle Scholar
  92. 92.
    Foutch PG, Talbert GA, Waring JP, Sanowski RA. Percutaneous endoscopic gastrostomy in patients with prior abdominal surgery: virtues of the safe tract. Am J Gastroenterol. 1988;83(2):147–50.PubMedGoogle Scholar
  93. 93.
    Heuss LT, Froehlich F, Beglinger C. Changing patterns of sedation and monitoring practice during endoscopy: results of a nationwide survey in Switzerland. Endoscopy. 2005;37(2):161–6.PubMedCrossRefGoogle Scholar
  94. 94.
    Fujiwara Y, Arakawa T, Fukuda T, Kimura S, Uchida T, Obata A, et al. Diagnosis of borderline adenomas of the stomach by endoscopic mucosal resection. Endoscopy. 1996;28(5):425–30.PubMedCrossRefGoogle Scholar
  95. 95.
    Muehldorfer SM, Stolte M, Martus P, Hahn EG, Ell C, Multicenter Study Group Gastric P. Diagnostic accuracy of forceps biopsy versus polypectomy for gastric polyps: a prospective multicentre study. Gut. 2002;50(4):465–70.Google Scholar
  96. 96.
    Lanza FL, Graham DY, Nelson RS, Godines R, McKechnie JC. Endoscopic upper gastrointestinal polypectomy. Report of 73 polypectomies in 63 patients. Am J Gastroenterol. 1981;75(5):345–8.PubMedGoogle Scholar
  97. 97.
    Hsieh YH, Lin HJ, Tseng GY, Perng CL, Li AF, Chang FY, et al. Is submucosal epinephrine injection necessary before polypectomy? A prospective, comparative study. Hepatogastroenterology. 2001;48(41):1379–82.PubMedGoogle Scholar
  98. 98.
    Muhldorfer SM, Kekos G, Hahn EG, Ell C. Complications of therapeutic gastrointestinal endoscopy. Endoscopy. 1992;24(4):276–83.PubMedCrossRefGoogle Scholar
  99. 99.
    Bardan E, Maor Y, Carter D, Lang A, Bar-Meir S, Avidan B. Endoscopic ultrasound (EUS) before gastric polyp resection: is it mandatory? J Clin Gastroenterol. 2007;41(4):371–4.PubMedCrossRefGoogle Scholar
  100. 100.
    Committee AT, Hwang JH, Konda V, Abu Dayyeh BK, Chauhan SS, Enestvedt BK, et al. Endoscopic mucosal resection. Gastrointest Endosc. 2015;82(2):215–26.Google Scholar
  101. 101.
    Tomizawa Y, Iyer PG, Wong Kee Song LM, Buttar NS, Lutzke LS, Wang KK. Safety of endoscopic mucosal resection for Barrett’s esophagus. Am J Gastroenterol. 2013;108(9):1440–7 (quiz 8).Google Scholar
  102. 102.
    Oka S, Tanaka S, Kaneko I, Mouri R, Hirata M, Kawamura T, et al. Advantage of endoscopic submucosal dissection compared with EMR for early gastric cancer. Gastrointest Endosc. 2006;64(6):877–83.PubMedCrossRefGoogle Scholar
  103. 103.
    Catalano F, Trecca A, Rodella L, Lombardo F, Tomezzoli A, Battista S, et al. The modern treatment of early gastric cancer: our experience in an Italian cohort. Surg Endosc. 2009;23(7):1581–6.PubMedCrossRefGoogle Scholar
  104. 104.
    Nakamoto S, Sakai Y, Kasanuki J, Kondo F, Ooka Y, Kato K, et al. Indications for the use of endoscopic mucosal resection for early gastric cancer in Japan: a comparative study with endoscopic submucosal dissection. Endoscopy. 2009;41(9):746–50.PubMedCrossRefGoogle Scholar
  105. 105.
    Okano A, Hajiro K, Takakuwa H, Nishio A, Matsushita M. Predictors of bleeding after endoscopic mucosal resection of gastric tumors. Gastrointest Endosc. 2003;57(6):687–90.PubMedCrossRefGoogle Scholar
  106. 106.
    Konda VJ, Gonzalez Haba Ruiz M, Koons A, Hart J, Xiao SY, Siddiqui UD, et al. Complete endoscopic mucosal resection is effective and durable treatment for Barrett’s-associated neoplasia. Clin Gastroenterol Hepatol. 2014;12(12):2002–10 (e1–2).Google Scholar
  107. 107.
    van Vilsteren FG, Pouw RE, Seewald S, Alvarez Herrero L, Sondermeijer CM, Visser M, et al. Stepwise radical endoscopic resection versus radiofrequency ablation for Barrett’s oesophagus with high-grade dysplasia or early cancer: a multicentre randomised trial. Gut. 2011;60(6):765–73.PubMedCrossRefGoogle Scholar
  108. 108.
    Park YM, Cho E, Kang HY, Kim JM. The effectiveness and safety of endoscopic submucosal dissection compared with endoscopic mucosal resection for early gastric cancer: a systematic review and metaanalysis. Surg Endosc. 2011;25(8):2666–77.PubMedCrossRefGoogle Scholar
  109. 109.
    Fanning SB, Bourke MJ, Williams SJ, Chung A, Kariyawasam VC. Giant laterally spreading tumors of the duodenum: endoscopic resection outcomes, limitations, and caveats. Gastrointest Endosc. 2012;75(4):805–12.PubMedCrossRefGoogle Scholar
  110. 110.
    Larghi A, Lightdale CJ, Memeo L, Bhagat G, Okpara N, Rotterdam H. EUS followed by EMR for staging of high-grade dysplasia and early cancer in Barrett’s esophagus. Gastrointest Endosc. 2005;62(1):16–23.PubMedCrossRefGoogle Scholar
  111. 111.
    Fujishiro M, Yahagi N, Kakushima N, Kodashima S, Muraki Y, Ono S, et al. Endoscopic submucosal dissection of esophageal squamous cell neoplasms. Clin Gastroenterol Hepatol. 2006;4(6):688–94.PubMedCrossRefGoogle Scholar
  112. 112.
    Peters FP, Kara MA, Rosmolen WD, ten Kate FJ, Krishnadath KK, van Lanschot JJ, et al. Stepwise radical endoscopic resection is effective for complete removal of Barrett’s esophagus with early neoplasia: a prospective study. Am J Gastroenterol. 2006;101(7):1449–57.PubMedCrossRefGoogle Scholar
  113. 113.
    Qumseya B, Panossian AM, Rizk C, Cangemi D, Wolfsen C, Raimondo M, et al. Predictors of esophageal stricture formation post endoscopic mucosal resection. Clin Endosc. 2014;47(2):155–61.PubMedPubMedCentralCrossRefGoogle Scholar
  114. 114.
    Yoshida N, Naito Y, Kugai M, Inoue K, Wakabayashi N, Yagi N, et al. Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors. World J Gastroenterol. 2010;16(33):4180–6.PubMedPubMedCentralCrossRefGoogle Scholar
  115. 115.
    Chung IK, Lee JH, Lee SH, Kim SJ, Cho JY, Cho WY, et al. Therapeutic outcomes in 1000 cases of endoscopic submucosal dissection for early gastric neoplasms: Korean ESD Study Group multicenter study. Gastrointest Endosc. 2009;69(7):1228–35.PubMedCrossRefGoogle Scholar
  116. 116.
    Koh R, Hirasawa K, Yahara S, Oka H, Sugimori K, Morimoto M, et al. Antithrombotic drugs are risk factors for delayed postoperative bleeding after endoscopic submucosal dissection for gastric neoplasms. Gastrointest Endosc. 2013;78(3):476–83.PubMedCrossRefGoogle Scholar
  117. 117.
    Yang Z, Wu Q, Liu Z, Wu K, Fan D. Proton pump inhibitors versus histamine-2-receptor antagonists for the management of iatrogenic gastric ulcer after endoscopic mucosal resection or endoscopic submucosal dissection: a meta-analysis of randomized trials. Digestion. 2011;84(4):315–20.PubMedCrossRefGoogle Scholar
  118. 118.
    Lian J, Chen S, Zhang Y, Qiu F. A meta-analysis of endoscopic submucosal dissection and EMR for early gastric cancer. Gastrointest Endosc. 2012;76(4):763–70.PubMedCrossRefGoogle Scholar
  119. 119.
    Jung JH, Choi KD, Ahn JY, Lee JH, Jung HY, Choi KS, et al. Endoscopic submucosal dissection for sessile, nonampullary duodenal adenomas. Endoscopy. 2013;45(2):133–5.PubMedCrossRefGoogle Scholar
  120. 120.
    Guo HM, Zhang XQ, Chen M, Huang SL, Zou XP. Endoscopic submucosal dissection vs endoscopic mucosal resection for superficial esophageal cancer. World J Gastroenterol. 2014;20(18):5540–7.PubMedPubMedCentralCrossRefGoogle Scholar
  121. 121.
    Nakajima T, Saito Y, Tanaka S, Iishi H, Kudo SE, Ikematsu H, et al. Current status of endoscopic resection strategy for large, early colorectal neoplasia in Japan. Surg Endosc. 2013;27(9):3262–70.PubMedCrossRefGoogle Scholar
  122. 122.
    Takahashi H, Arimura Y, Masao H, Okahara S, Tanuma T, Kodaira J, et al. Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video). Gastrointest Endosc. 2010;72(2):255–64 (e1–2).Google Scholar
  123. 123.
    Mizuta H, Nishimori I, Kuratani Y, Higashidani Y, Kohsaki T, Onishi S. Predictive factors for esophageal stenosis after endoscopic submucosal dissection for superficial esophageal cancer. Dis Esophagus. 2009;22(7):626–31.PubMedCrossRefGoogle Scholar
  124. 124.
    Ono S, Fujishiro M, Niimi K, Goto O, Kodashima S, Yamamichi N, et al. Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms. Endoscopy. 2009;41(8):661–5.PubMedCrossRefGoogle Scholar
  125. 125.
    Kim JS, Kim BW, Shin IS. Efficacy and safety of endoscopic submucosal dissection for superficial squamous esophageal neoplasia: a meta-analysis. Dig Dis Sci. 2014;59(8):1862–9.PubMedCrossRefGoogle Scholar
  126. 126.
    Isomoto H, Yamaguchi N, Minami H, Nakao K. Management of complications associated with endoscopic submucosal dissection/ endoscopic mucosal resection for esophageal cancer. Dig Endosc. 2013;25(Suppl 1):29–38.PubMedCrossRefGoogle Scholar
  127. 127.
    Mori H, Rafiq K, Kobara H, Fujihara S, Nishiyama N, Oryuu M, et al. Steroid permeation into the artificial ulcer by combined steroid gel application and balloon dilatation: prevention of esophageal stricture. J Gastroenterol Hepatol. 2013;28(6):999–1003.PubMedCrossRefGoogle Scholar
  128. 128.
    Wen J, Lu Z, Yang Y, Liu Q, Yang J, Wang S, et al. Preventing stricture formation by covered esophageal stent placement after endoscopic submucosal dissection for early esophageal cancer. Dig Dis Sci. 2014;59(3):658–63.PubMedCrossRefGoogle Scholar
  129. 129.
    Dulai GS, Jensen DM, Cortina G, Fontana L, Ippoliti A. Randomized trial of argon plasma coagulation vs. multipolar electrocoagulation for ablation of Barrett’s esophagus. Gastrointest Endosc. 2005;61(2):232–40.PubMedCrossRefGoogle Scholar
  130. 130.
    Luman W, Lessels AM, Palmer KR. Failure of Nd–YAG photocoagulation therapy as treatment for Barrett’s oesophagus—a pilot study. Eur J Gastroenterol Hepatol. 1996;8(7):627–30.PubMedGoogle Scholar
  131. 131.
    Michopoulos S, Tsibouris P, Bouzakis H, Sotiropoulou M, Kralios N. Complete regression of Barrett’s esophagus with heat probe thermocoagulation: mid-term results. Gastrointest Endosc. 1999;50(2):165–72.PubMedCrossRefGoogle Scholar
  132. 132.
    Sampliner RE, Faigel D, Fennerty MB, Lieberman D, Ippoliti A, Lewin K, et al. Effective and safe endoscopic reversal of nondysplastic Barrett’s esophagus with thermal electrocoagulation combined with high-dose acid inhibition: a multicenter study. Gastrointest Endosc. 2001;53(6):554–8.PubMedCrossRefGoogle Scholar
  133. 133.
    Prost B, Poncet G, Scoazec JY, Saurin JC. Unusual complications of argon plasma coagulation. Gastrointest Endosc. 2004;59(7):929–32.PubMedCrossRefGoogle Scholar
  134. 134.
    Roman S, Saurin JC, Dumortier J, Perreira A, Bernard G, Ponchon T. Tolerance and efficacy of argon plasma coagulation for controlling bleeding in patients with typical and atypical manifestations of watermelon stomach. Endoscopy. 2003;35(12):1024–8.PubMedCrossRefGoogle Scholar
  135. 135.
    Herrera S, Bordas JM, Llach J, Gines A, Pellise M, Fernandez-Esparrach G, et al. The beneficial effects of argon plasma coagulation in the management of different types of gastric vascular ectasia lesions in patients admitted for GI hemorrhage. Gastrointest Endosc. 2008;68(3):440–6.PubMedCrossRefGoogle Scholar
  136. 136.
    Overholt BF, Wang KK, Burdick JS, Lightdale CJ, Kimmey M, Nava HR, et al. Five-year efficacy and safety of photodynamic therapy with Photofrin in Barrett’s high-grade dysplasia. Gastrointest Endosc. 2007;66(3):460–8.PubMedCrossRefGoogle Scholar
  137. 137.
    Petersen BT, Chuttani R, Croffie J, DiSario J, Liu J, Mishkin D, et al. Photodynamic therapy for gastrointestinal disease. Gastrointest Endosc. 2006;63(7):927–32.PubMedCrossRefGoogle Scholar
  138. 138.
    Dunkin BJ, Martinez J, Bejarano PA, Smith CD, Chang K, Livingstone AS, et al. Thin-layer ablation of human esophageal epithelium using a bipolar radiofrequency balloon device. Surg Endosc. 2006;20(1):125–30.PubMedCrossRefGoogle Scholar
  139. 139.
    Smith CD, Bejarano PA, Melvin WS, Patti MG, Muthusamy R, Dunkin BJ. Endoscopic ablation of intestinal metaplasia containing high-grade dysplasia in esophagectomy patients using a balloon-based ablation system. Surg Endosc. 2007;21(4):560–9.PubMedCrossRefGoogle Scholar
  140. 140.
    Shaheen NJ, Sharma P, Overholt BF, Wolfsen HC, Sampliner RE, Wang KK, et al. Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Engl J Med. 2009;360(22):2277–88.PubMedCrossRefGoogle Scholar
  141. 141.
    Pouw RE, Gondrie JJ, Van Vilsteren FG, Sondermeijer C, Rosmolen W, Curvers WL, et al. Complications following circumferential radiofrequency energy ablation of Barrett’s esophagus containing early neoplasia. Gastrointestinal Endoscopy. 67(5):AB145.Google Scholar
  142. 142.
    Lyday WD, Corbett FS, Kuperman DA, Kalvaria I, Mavrelis PG, Shughoury AB, et al. Radiofrequency ablation of Barrett’s esophagus: outcomes of 429 patients from a multicenter community practice registry. Endoscopy. 2010;42(4):272–8.PubMedCrossRefGoogle Scholar
  143. 143.
    Vahabzadeh B, Rastogi A, Bansal A, Sharma P. Use of a plastic endoprosthesis to successfully treat esophageal perforation following radiofrequency ablation of Barrett’s esophagus. Endoscopy. 2011;43(1):67–9.PubMedCrossRefGoogle Scholar
  144. 144.
    Greenwald BD, Dumot JA, Abrams JA, Lightdale CJ, David DS, Nishioka NS, et al. Endoscopic spray cryotherapy for esophageal cancer: safety and efficacy. Gastrointest Endosc. 2010;71(4):686–93.PubMedPubMedCentralCrossRefGoogle Scholar
  145. 145.
    Greenwald BD, Dumot JA, Horwhat JD, Lightdale CJ, Abrams JA. Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagus. Dis Esophagus. 2010;23(1):13–9.PubMedCrossRefGoogle Scholar
  146. 146.
    Repici A, Hassan C, Sharma P, Conio M, Siersema P. Systematic review: the role of self-expanding plastic stents for benign oesophageal strictures. Aliment Pharmacol Ther. 2010;31(12):1268–75.PubMedCrossRefGoogle Scholar
  147. 147.
    Bakken JC, Wong Kee Song LM, de Groen PC, Baron TH. Use of a fully covered self-expandable metal stent for the treatment of benign esophageal diseases. Gastrointest Endosc. 2010;72(4):712–20.Google Scholar
  148. 148.
    van Boeckel PG, Dua KS, Weusten BL, Schmits RJ, Surapaneni N, Timmer R, et al. Fully covered self-expandable metal stents (SEMS), partially covered SEMS and self-expandable plastic stents for the treatment of benign esophageal ruptures and anastomotic leaks. BMC Gastroenterol. 2012;12:19.PubMedPubMedCentralCrossRefGoogle Scholar
  149. 149.
    Dua KS, Latif SU, Yang JF, Fang TC, Khan A, Oh Y. Efficacy and safety of a new fully covered self-expandable non-foreshortening metal esophageal stent. Gastrointest Endosc. 2014;80(4):577–85.PubMedCrossRefGoogle Scholar
  150. 150.
    Kozarek R, Baron T, Song HY. Self-expandable stents in the gastrointestinal tract. New York: Springer; 2012.Google Scholar
  151. 151.
    Knyrim K, Wagner HJ, Bethge N, Keymling M, Vakil N. A controlled trial of an expansile metal stent for palliation of esophageal obstruction due to inoperable cancer. N Engl J Med. 1993;329(18):1302–7.PubMedCrossRefGoogle Scholar
  152. 152.
    Sandha GS, Marcon NE. Expandable metal stents for benign esophageal obstruction. Gastrointest Endosc Clin N Am. 1999;9(3):437–46.PubMedGoogle Scholar
  153. 153.
    Ackroyd R, Watson DI, Devitt PG, Jamieson GG. Expandable metallic stents should not be used in the treatment of benign esophageal strictures. J Gastroenterol Hepatol. 2001;16(4):484–7.PubMedCrossRefGoogle Scholar
  154. 154.
    Hirdes MM, Vleggaar FP, Van der Linde K, Willems M, Totte ER, Siersema PD. Esophageal perforation due to removal of partially covered self-expanding metal stents placed for a benign perforation or leak. Endoscopy. 2011;43(2):156–9.PubMedCrossRefGoogle Scholar
  155. 155.
    Hramiec JE, O’Shea MA, Quinlan RM. Expandable metallic esophageal stents in benign disease: a cause for concern. Surg Laparosc Endosc. 1998;8(1):40–3.PubMedCrossRefGoogle Scholar
  156. 156.
    Shenfine J, McNamee P, Steen N, Bond J, Griffin SM. A randomized controlled clinical trial of palliative therapies for patients with inoperable esophageal cancer. Am J Gastroenterol. 2009;104(7):1674–85.PubMedCrossRefGoogle Scholar
  157. 157.
    Jacobson BC, Hirota W, Baron TH, Leighton JA, Faigel DO. Standards of practice committee. American Society for gastrointestinal E. The role of endoscopy in the assessment and treatment of esophageal cancer. Gastrointest Endosc. 2003;57(7):817–22.PubMedCrossRefGoogle Scholar
  158. 158.
    Kozarek RA, Ball TJ, Patterson DJ. Metallic self-expanding stent application in the upper gastrointestinal tract: caveats and concerns. Gastrointest Endosc. 1992;38(1):1–6.PubMedCrossRefGoogle Scholar
  159. 159.
    Tierney W, Chuttani R, Croffie J, DiSario J, Liu J, Mishkin DS, et al. Enteral stents. Gastrointest Endosc. 2006;63(7):920–6.PubMedCrossRefGoogle Scholar
  160. 160.
    Wenger U, Luo J, Lundell L, Lagergren J. A nationwide study of the use of self-expanding stents in patients with esophageal cancer in Sweden. Endoscopy. 2005;37(4):329–34.PubMedCrossRefGoogle Scholar
  161. 161.
    Siersema PD, Tan TG, Sutorius FF, Dees J, van Blankenstein M. Massive hemorrhage caused by a perforating Gianturco-Z stent resulting in an aortoesophageal fistula. Endoscopy. 1997;29(5):416–20.PubMedCrossRefGoogle Scholar
  162. 162.
    Homs MY, Wahab PJ, Kuipers EJ, Steyerberg EW, Grool TA, Haringsma J, et al. Esophageal stents with antireflux valve for tumors of the distal esophagus and gastric cardia: a randomized trial. Gastrointest Endosc. 2004;60(5):695–702.PubMedCrossRefGoogle Scholar
  163. 163.
    Gaidos JK, Draganov PV. Treatment of malignant gastric outlet obstruction with endoscopically placed self-expandable metal stents. World J Gastroenterol. 2009;15(35):4365–71.PubMedPubMedCentralCrossRefGoogle Scholar
  164. 164.
    Tringali A, Didden P, Repici A, Spaander M, Bourke MJ, Williams SJ, et al. Endoscopic treatment of malignant gastric and duodenal strictures: a prospective, multicenter study. Gastrointest Endosc. 2014;79(1):66–75.PubMedCrossRefGoogle Scholar
  165. 165.
    Maetani I, Ukita T, Tada T, Shigoka H, Omuta S, Endo T. Metallic stents for gastric outlet obstruction: reintervention rate is lower with uncovered versus covered stents, despite similar outcomes. Gastrointest Endosc. 2009;69(4):806–12.PubMedCrossRefGoogle Scholar
  166. 166.
    Piesman M, Kozarek RA, Brandabur JJ, Pleskow DK, Chuttani R, Eysselein VE, et al. Improved oral intake after palliative duodenal stenting for malignant obstruction: a prospective multicenter clinical trial. Am J Gastroenterol. 2009;104(10):2404–11.PubMedCrossRefGoogle Scholar
  167. 167.
    Baron TH. Minimizing endoscopic complications: endoluminal stents. Gastrointest Endosc Clin N Am. 2007;17(1):83–104 (vii).Google Scholar
  168. 168.
    El-Tawil AM. Trends on gastrointestinal bleeding and mortality: where are we standing? World J Gastroenterol. 2012;18(11):1154–8.PubMedPubMedCentralCrossRefGoogle Scholar
  169. 169.
    Hwang JH, Shergill AK, Acosta RD, Chandrasekhara V, Chathadi KV, Decker GA, et al. The role of endoscopy in the management of variceal hemorrhage. Gastrointest Endosc. 2014;80(2):221–7.PubMedCrossRefGoogle Scholar
  170. 170.
    Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Practice guidelines committee of the American Association for the study of liver D, practice parameters committee of the American College of G. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46(3):922–38.PubMedCrossRefGoogle Scholar
  171. 171.
    Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila F, Soares-Weiser K, Mendez-Sanchez N, Gluud C, et al. Meta-analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding—an updated Cochrane review. Aliment Pharmacol Ther. 2011;34(5):509–18.PubMedCrossRefGoogle Scholar
  172. 172.
    Soares-Weiser K, Brezis M, Tur-Kaspa R, Leibovici L. Antibiotic prophylaxis for cirrhotic patients with gastrointestinal bleeding. Cochrane Database Syst Rev. 2002(2):CD002907.Google Scholar
  173. 173.
    Koch DG, Arguedas MR, Fallon MB. Risk of aspiration pneumonia in suspected variceal hemorrhage: the value of prophylactic endotracheal intubation prior to endoscopy. Dig Dis Sci. 2007;52(9):2225–8.PubMedCrossRefGoogle Scholar
  174. 174.
    Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Ann Intern Med. 1995;123(4):280–7.PubMedCrossRefGoogle Scholar
  175. 175.
    Schuman BM, Beckman JW, Tedesco FJ, Griffin JW Jr, Assad RT. Complications of endoscopic injection sclerotherapy: a review. Am J Gastroenterol. 1987;82(9):823–30.PubMedGoogle Scholar
  176. 176.
    Poza Cordon J, Froilan Torres C, Burgos Garcia A, Gea Rodriguez F, Suarez de Parga JM. Endoscopic management of esophageal varices. World J Gastrointest Endosc. 2012;4(7):312–22.Google Scholar
  177. 177.
    Young MF, Sanowski RA, Rasche R. Comparison and characterization of ulcerations induced by endoscopic ligation of esophageal varices versus endoscopic sclerotherapy. Gastrointest Endosc. 1993;39(2):119–22.PubMedCrossRefGoogle Scholar
  178. 178.
    Sarin SK, Sachdev G, Nanda R, Batra SK, Anand BS. Comparison of the two time schedules for endoscopic sclerotherapy: a prospective randomised controlled study. Gut. 1986;27(6):710–3.PubMedPubMedCentralCrossRefGoogle Scholar
  179. 179.
    Westaby D, Melia WM, Macdougall BR, Hegarty JE, Williams R. Injection sclerotherapy for oesophageal varices: a prospective randomised trial of different treatment schedules. Gut. 1984;25(2):129–32.PubMedPubMedCentralCrossRefGoogle Scholar
  180. 180.
    Shephard H, Barkin JS. Omeprazole heals mucosal ulcers associated with endoscopic injection sclerotherapy. Gastrointest Endosc. 1993;39(3):474–5.PubMedCrossRefGoogle Scholar
  181. 181.
    Dai C, Liu WX, Jiang M, Sun MJ. Endoscopic variceal ligation compared with endoscopic injection sclerotherapy for treatment of esophageal variceal hemorrhage: a meta-analysis. World J Gastroenterol. 2015;21(8):2534–41.PubMedPubMedCentralCrossRefGoogle Scholar
  182. 182.
    Avgerinos A, Armonis A, Stefanidis G, Mathou N, Vlachogiannakos J, Kougioumtzian A, et al. Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis. Hepatology. 2004;39(6):1623–30.PubMedCrossRefGoogle Scholar
  183. 183.
    Piai G, Cipolletta L, Claar M, Marone G, Bianco MA, Forte G, et al. Prophylactic sclerotherapy of high-risk esophageal varices: results of a multicentric prospective controlled trial. Hepatology. 1988;8(6):1495–500.PubMedCrossRefGoogle Scholar
  184. 184.
    Yuki M, Kazumori H, Yamamoto S, Shizuku T, Kinoshita Y. Prognosis following endoscopic injection sclerotherapy for esophageal varices in adults: 20-year follow-up study. Scand J Gastroenterol. 2008;43(10):1269–74.PubMedCrossRefGoogle Scholar
  185. 185.
    Schmitz RJ, Sharma P, Badr AS, Qamar MT, Weston AP. Incidence and management of esophageal stricture formation, ulcer bleeding, perforation, and massive hematoma formation from sclerotherapy versus band ligation. Am J Gastroenterol. 2001;96(2):437–41.PubMedCrossRefGoogle Scholar
  186. 186.
    Koch H, Henning H, Grimm H, Soehendra N. Prophylactic sclerosing of esophageal varices–results of a prospective controlled study. Endoscopy. 1986;18(2):40–3.PubMedCrossRefGoogle Scholar
  187. 187.
    Stiegmann GV, Goff JS, Michaletz-Onody PA, Korula J, Lieberman D, Saeed ZA, et al. Endoscopic sclerotherapy as compared with endoscopic ligation for bleeding esophageal varices. N Engl J Med. 1992;326(23):1527–32.PubMedCrossRefGoogle Scholar
  188. 188.
    Sorensen T, Burcharth F, Pedersen ML, Findahl F. Oesophageal stricture and dysphagia after endoscopic sclerotherapy for bleeding varices. Gut. 1984;25(5):473–7.PubMedPubMedCentralCrossRefGoogle Scholar
  189. 189.
    Deboever G, Elegeert I, Defloor E. Portal and mesenteric venous thrombosis after endoscopic injection sclerotherapy. Am J Gastroenterol. 1989;84(10):1336–7.PubMedGoogle Scholar
  190. 190.
    Stoltenberg PH, Goodale RL, Silvis SE. Portal vein thrombosis following combined endoscopic variceal sclerosis and vasopressin therapy for bleeding varices. Am J Gastroenterol. 1987;82(12):1297–300.PubMedGoogle Scholar
  191. 191.
    Terada T, Nakanuma Y, Yonejima M, Yokoyama H, Koike N. Portal, mesenteric, and splenic venous thrombosis after endoscopic injection sclerotherapy. J Clin Gastroenterol. 1990;12(2):238–9.PubMedCrossRefGoogle Scholar
  192. 192.
    Ibrarullah M, Wagholikar G, Srinivas M, Mishra A, Reddy DG, Prasadbabu TL. Acute mesenteric venous thrombosis complicating endoscopic variceal sclerotherapy with absolute alcohol. Indian J Gastroenterol. 2003;22(1):27–9.PubMedGoogle Scholar
  193. 193.
    Alexander S, Korman MG, Sievert W. Cyanoacrylate in the treatment of gastric varices complicated by multiple pulmonary emboli. Intern Med J. 2006;36(7):462–5.PubMedCrossRefGoogle Scholar
  194. 194.
    Neumann H, Scheidbach H, Monkemuller K, Pech M, Malfertheiner P. Multiple cyanoacrylate (histoacryl) emboli after injection therapy of cardia varices. Gastrointest Endosc. 2009;70(5):1025–6 (discussion 6).Google Scholar
  195. 195.
    Jia Y, Dwivedi A, Elhanafi S, Ortiz A, Othman M, Zuckerman M. Low risk of bacteremia after endoscopic variceal therapy for esophageal varices: a systematic review and meta-analysis. Endosc Int Open. 2015;3(5):E409–17.PubMedPubMedCentralCrossRefGoogle Scholar
  196. 196.
    Shaheen NJ, Stuart E, Schmitz SM, Mitchell KL, Fried MW, Zacks S, et al. Pantoprazole reduces the size of postbanding ulcers after variceal band ligation: a randomized, controlled trial. Hepatology. 2005;41(3):588–94.PubMedCrossRefGoogle Scholar
  197. 197.
    Vanbiervliet G, Giudicelli-Bornard S, Piche T, Berthier F, Gelsi E, Filippi J, et al. Predictive factors of bleeding related to post-banding ulcer following endoscopic variceal ligation in cirrhotic patients: a case-control study. Aliment Pharmacol Ther. 2010;32(2):225–32.PubMedCrossRefGoogle Scholar
  198. 198.
    Tayama C, Iwao T, Oho K, Toyonaga A, Tanikawa K. Effect of large fundal varices on changes in gastric mucosal hemodynamics after endoscopic variceal ligation. Endoscopy. 1998;30(1):25–31.PubMedCrossRefGoogle Scholar
  199. 199.
    de la Pena J, Rivero M, Sanchez E, Fabrega E, Crespo J, Pons-Romero F. Variceal ligation compared with endoscopic sclerotherapy for variceal hemorrhage: prospective randomized trial. Gastrointest Endosc. 1999;49(4 Pt 1):417–23.PubMedCrossRefGoogle Scholar
  200. 200.
    Laine L, el-Newihi HM, Migikovsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Ann Intern Med. 1993;119(1):1–7.Google Scholar
  201. 201.
    Hwang JH, Fisher DA, Ben-Menachem T, Chandrasekhara V, Chathadi K, Decker GA, et al. The role of endoscopy in the management of acute non-variceal upper GI bleeding. Gastrointest Endosc. 2012;75(6):1132–8.PubMedCrossRefGoogle Scholar
  202. 202.
    Rehman A, Iscimen R, Yilmaz M, Khan H, Belsher J, Gomez JF, et al. Prophylactic endotracheal intubation in critically ill patients undergoing endoscopy for upper GI hemorrhage. Gastrointest Endosc. 2009;69(7):e55–9.PubMedPubMedCentralCrossRefGoogle Scholar
  203. 203.
    Lohse N, Lundstrom LH, Vestergaard TR, Risom M, Rosenstock SJ, Foss NB, et al. Anaesthesia care with and without tracheal intubation during emergency endoscopy for peptic ulcer bleeding: a population-based cohort study. Br J Anaesth. 2015;114(6):901–8.PubMedCrossRefGoogle Scholar
  204. 204.
    Liou TC, Lin SC, Wang HY, Chang WH. Optimal injection volume of epinephrine for endoscopic treatment of peptic ulcer bleeding. World J Gastroenterol. 2006;12(19):3108–13.PubMedPubMedCentralCrossRefGoogle Scholar
  205. 205.
    Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clin Gastroenterol Hepatol. 2009;7(1):33–47 (quiz 1–2).Google Scholar
  206. 206.
    Marmo R, Rotondano G, Piscopo R, Bianco MA, D’Angella R, Cipolletta L. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol. 2007;102(2):279–89 (quiz 469).Google Scholar
  207. 207.
    Sung JJ, Tsoi KK, Lai LH, Wu JC, Lau JY. Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut. 2007;56(10):1364–73.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • C. Andrew Kistler
    • 1
  • Aaron Martin
    • 1
  • Jeremy Kaplan
    • 1
  • Joseph Yoo
    • 1
  • Ali A. Siddiqui
    • 1
    • 2
    Email author
  1. 1.Division of Gastroenterology and HepatologyThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of GastroenterologyThomas Jefferson University HospitalPhiladelphiaUSA

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