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Progress of Controlled Drug Delivery Systems in Topical Ophthalmology: Focus on Nano and Micro Drug Carriers

  • Ameeduzzafar Zafar
  • Javed Ahmad
  • Richard T. Addo
  • Sohail Akhter
Chapter

Abstract

Corneal and conjunctival epithelia, along with the tear film, serve as biological barriers to protect the eye from the entrance of potentially harmful substances. These barriers create constraint effective drug medication of ocular diseases with topical ocular formulations. Designing an effective therapy for ocular diseases, especially for the anterior segment, has been considered a challenging task. Nano-drug carriers giving us an array of hope for ocular drug therapy, owing to its potential to improve the ocular retention, controlled release, trans-corneal permeation and thus intra-ocular drug availability. Nanotechnology-based formulation design is important in ocular pharmaceuticals yet knowledge of anatomy and physiology of eyes are critical along with the understanding of nanoparticles design. Here, we discussed the ocular transport of topically applied drug, different barriers in its path and how the nanoparticles as drug carriers can improve the drug delivery to the eyes.

Keywords

Ocular drug delivery Topical administration Drug transport barriers Controlled drug release Nanotechnology Targeting 

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© Springer International Publishing AG 2016

Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Authors and Affiliations

  • Ameeduzzafar Zafar
    • 1
  • Javed Ahmad
    • 2
  • Richard T. Addo
    • 3
  • Sohail Akhter
    • 4
    • 5
  1. 1.Department of Pharmaceutics, Faculty of PharmacyJamia Hamdard UniversityNew DelhiIndia
  2. 2.Department of PharmaceuticsNational Institute of Pharmaceutical Education and Research (NIPER)RaebareliIndia
  3. 3.Department of Pharmaceutical Sciences, School of PharmacyUnion UniversityJacksonUSA
  4. 4.LE STUDIUM® Loire Valley Institute for Advanced Studies, Centre-Val de Loire regionOrléansFrance
  5. 5.Nucleic Acids Transfer by Non-Viral MethodsCentre de Biophysique MoléculaireOrléansFrance

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