A Semi-supervised Large Margin Algorithm for White Matter Hyperintensity Segmentation

Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10019)


Precise detection and quantification of white matter hyperintensities (WMH) is of great interest in studies of neurodegenerative diseases (NDs). In this work, we propose a novel semi-supervised large margin algorithm for the segmentation of WMH. The proposed algorithm optimizes a kernel based max-margin objective function which aims to maximize the margin averaged over inliers and outliers while exploiting a limited amount of available labelled data. We show that the learning problem can be formulated as a joint framework learning a classifier and a label assignment simultaneously, which can be solved efficiently by an iterative algorithm. We evaluate our method on a database of 280 brain Magnetic Resonance (MR) images from subjects that either suffered from subjective memory complaints or were diagnosed with NDs. The segmented WMH volumes correlate well with the standard clinical measurement (Fazekas score), and both the qualitative visualization results and quantitative correlation scores of the proposed algorithm outperform other well known methods for WMH segmentation.


Dementia With Lewy Body White Matter Hyperintensities Label Data Subjective Memory Complaint Label Assignment 
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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of ComputingImperial College LondonLondonUK
  2. 2.Department of NeurologyVU University Medical CenterAmsterdamThe Netherlands

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