Clinical Presentation of Acute Cutaneous Graft-Versus-Host Disease
Acute cutaneous graft-versus-host disease (aGVHD) has a variety of clinical presentations. In the early posttransplantation setting, histologic confirmation of aGVHD via skin biopsy is frequently equivocal. Additional clinical information may be necessary to differentiate aGVHD from its clinical mimickers such as viral exanthema, morbilliform drug eruptions, engraftment syndrome (ES), pre-engraftment syndrome (PES), and in severe cases, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) [1–3].
KeywordsAcute graft-versus-host disease aGVHD Hematopoietic stem cell transplantation HSCT
- 4.Hymes SR, Alousi AM, Cowen EW. Graft-versus-host disease: part I. Pathogenesis and clinical manifestations of graft-versus-host disease. J Am Acad Dermatol 2012;66:515.e1–18; quiz 533–4.Google Scholar
- 7.Macedo FI, Faris J, Lum LG, Gabali A, Uberti JP, Ratanatharathorn V, White MT. Extensive toxic epidermal necrolysis versus acute graft versus host disease after allogenic hematopoietic stem-cell transplantation: challenges in diagnosis and management. J Burn Care Res. 2014;35:e431–5.CrossRefPubMedGoogle Scholar