Spatially Adaptive Spectral Denoising for MR Spectroscopic Imaging using Frequency-Phase Non-local Means

  • Dhritiman DasEmail author
  • Eduardo Coello
  • Rolf F. Schulte
  • Bjoern H. Menze
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9902)


Magnetic resonance spectroscopic imaging (MRSI) is an imaging modality used for generating metabolic maps of the tissue in-vivo. These maps show the concentration of metabolites in the sample being investigated and their accurate quantification is important to diagnose diseases. However, the major roadblocks in accurate metabolite quantification are: low spatial resolution, long scanning times, poor signal-to-noise ratio (SNR) and the subsequent noise-sensitive non-linear model fitting. In this work, we propose a frequency-phase spectral denoising method based on the concept of non-local means (NLM) that improves the robustness of data analysis and scanning times while potentially increasing spatial resolution. We evaluate our method on simulated data sets as well as on human in-vivo MRSI data. Our denoising method improves the SNR while maintaining the spatial resolution of the spectra.



The research leading to these results has received funding from the European Union’s H2020 Framework Programme (H2020-MSCA-ITN-2014) under grant agreement no 642685 MacSeNet.


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Authors and Affiliations

  • Dhritiman Das
    • 1
    • 3
    Email author
  • Eduardo Coello
    • 2
    • 3
  • Rolf F. Schulte
    • 3
  • Bjoern H. Menze
    • 1
  1. 1.Department of Computer ScienceTechnical University of MunichMunichGermany
  2. 2.Department of PhysicsTechnical University of MunichMunichGermany
  3. 3.GE Global ResearchMunichGermany

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