A Multiscale Cardiac Model for Fast Personalisation and Exploitation
Computer models of the heart are of increasing interest for clinical applications due to their discriminative and predictive abilities. However a single 3D simulation can be computationally expensive and long, which can make some practical applications such as the personalisation phase, or a sensitivity analysis of mechanical parameters over the simulated behaviour quite slow. In this manuscript we present a multiscale 0D/3D model which allows us to have a reliable (and extremely fast) approximation of the behaviour of the 3D model under a few simplifying assumptions. We first detail the two different models, then explain the coupling of the two models to get fast 0D approximation of 3D simulations. Finally we demonstrated how the multiscale model can speed-up an efficient optimization algorithm, which enables a fast personalisation of the 3D simulations by leveraging on the advantages of each scale.
KeywordsComputational Burden Mesh Geometry Personalisation Process Cardiac Model Sarcomere Contraction
This work has been partially funded by the EU FP7-funded project MD-Paedigree (Grant Agreement 600932) and contributes to the objectives of the ERC advanced grant MedYMA (2011-291080).
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