Roles of Gap Junctions in Organizing Traveling Waves in a Hippocampal CA3 Network Model

  • Toshikazu Samura
  • Yutaka Sakai
  • Hatsuo Hayashi
  • Takeshi Aihara
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 9947)


Directional traveling waves are organized in a hippocampal CA3 recurrent network model composed of biophysical pyramidal cells and inhibitory interneurons with gap junctions. The network spontaneously organizes neuronal activities traveling in a particular direction and the organized traveling waves are modified by repetitive local inputs. We found that the distributions of inter-spike intervals (ISIs) of pyramidal cells and interneurons are involved with spontaneous traveling waves that can be modified by local stimulation. Similar ISI distributions emerge in a network that has no gap junctions, but strong mutual connections between pyramidal cells and interneurons. These results suggest that interaction between interneurons through gap junctions contributes to enhancing the inhibition of pyramidal cells for organizing traveling waves.


Hippocampus CA3 Traveling waves Gap junctions 


  1. 1.
    Lubenov, E.V., Siapas, A.G.: Hippocampal theta oscillations are travelling waves. Nature 459(7246), 534–539 (2009)CrossRefGoogle Scholar
  2. 2.
    Patel, J., Fujisawa, S., Berényi, A., Royer, S., Buzsáki, G.: Traveling theta waves along the entire septotemporal axis of the hippocampus. Neuron 75(3), 410–417 (2012)CrossRefGoogle Scholar
  3. 3.
    Samura, T., Hayashi, H.: Directional spike propagation in a recurrent network: dynamical firewall as anisotropic recurrent inhibition. Neural Netw. 33, 236–246 (2012)CrossRefGoogle Scholar
  4. 4.
    Samura, T., Yutaka, S., Hatsuo, H., Takeshi, A.: Localized anisotropic inhibition for self-organized directional traveling waves in the hippocampal CA3. In: The Proceedings of 24th Annual Conference of Japanese Neural Network Society, pp. 80–81 (2014)Google Scholar
  5. 5.
    Shinozaki, T., Naruse, Y., Câteau, H.: Gap junctions facilitate propagation of synchronous firing in the cortical neural population: a numerical simulation study. Neural Netw. 46, 91–98 (2013)CrossRefGoogle Scholar
  6. 6.
    Sik, A., Penttonen, M., Ylinen, A., Buzsáki, G.: Hippocampal CA1 interneurons: an in vivo intracellular labeling study. J. Neurosci. 15(10), 6651–6665 (1995)Google Scholar
  7. 7.
    Yang, Q., Michelson, H.B.: Gap junctions synchronize the firing of inhibitory interneurons in guinea pig hippocampus. Brain Res. 907(1–2), 139–143 (2001)CrossRefGoogle Scholar
  8. 8.
    Yoshida, M., Hayashi, H.: Regulation of spontaneous rhythmic activity and organization of pacemakers as memory traces by spike-timing-dependent synaptic plasticity in a hippocampal model. Phys. Rev. E 69(1), 011910:1–011910:15 (2004)MathSciNetCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Toshikazu Samura
    • 1
    • 2
  • Yutaka Sakai
    • 2
  • Hatsuo Hayashi
    • 3
  • Takeshi Aihara
    • 2
  1. 1.Graduate School of Sciences and Technology for InnovationYamaguchi UniversityUbeJapan
  2. 2.Tamagawa University Brain Science InstituteMachidaJapan
  3. 3.Kyushu Institute of TechnologyKitakyushuJapan

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