Computational Model of the Cerebellum and the Basal Ganglia for Interval Timing Learning
In temporal information processing, both the cerebellum and the basal ganglia play essential roles. In particular, for interval timing learning, the cerebellum exhibits temporally localized activity around the onset of the unconditioned stimulus, whereas the basal ganglia represents the passage of time by their ramping-up activity from the onset of the conditioned stimulus to that of the unconditioned stimulus. We present a unified computational model of the cerebellum and the basal ganglia for the interval timing learning task. We report that our model reproduces the localized activity in the cerebellum and the gradual increase of the activity in the basal ganglia. These results suggest that the cerebellum and the basal ganglia play different roles in temporal information processing.
KeywordsComputational model Cerebellum Basal ganglia Interval timing Relay hypothesis
We would like to thank Professor Masaki Tanaka at Hokkaido University for fruitful discussions on his relay hypothesis. Part of this work was supported by JSPS KAKENHI Grant Number 26119511. This paper is based on results obtained from a project commissioned by the New Energy and Industrial Technology Development Organization (NEDO).
- 6.McCormick, D.A., Thompson, R.F.: Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J. Neurosci. 4, 2811–2822 (1984)Google Scholar
- 7.Tanaka, M., Kunimatsu, J., Ohmae, S.: Neural representation of time. Brain Nerve 65, 941–948 (2013)Google Scholar
- 8.Kandel, E.R., Schwartz, J.H., Jessell, T.M., Siegelbaum, S.A., Hudspeth, A.J.: Principles of Neural Science, 5th edn. McGraw-Hill Companies Inc., New York (2013)Google Scholar