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Neurophysiological and Behavioral Dysfunctions After Electromagnetic Field Exposure: A Dose Response Relationship

  • Archana Sharma
  • Kavindra Kumar Kesari
  • H. N. Verma
  • Rashmi Sisodia
Chapter
Part of the Environmental Science and Engineering book series (ESE)

Abstract

For decades, there has been an increasing concern about the potential hazards of ionizing and non-ionizing radiations on human health. This chapter provides several evidences related to pathophysiology of electromagnetic field (EMF) and its effects on different tissues and organs with special reference to neurophysiological and behavioral dysfunctions. Developing central nervous system (CNS) is extremely sensitive to EMF due to various factors especially due to presence of the high amount of water content, lipids and low amount of antioxidant enzymes. Therefore, the study is focused on the effects of radio frequency (RF) EMF and extremely low frequency magnetic field (ELF MF) on neurological disorders. The severity of effects always depends on exposure doses like, exposure duration, position of subjects, power density and field intensity, which could be measured in terms of specific absorption rate (SAR). There are several biomarkers, which are very useful to measure the radiation effects in both in vitro and in vivo model. The most intensely studied biomarkers by various researchers in CNS are protein kinase C, micronuclei, mitochondrial pathways, melatonin, calcium ion concentration, antioxidant enzymes like glutathione, superoxide dismutase, catalase etc. EMF may also lead to alterations in neurotransmission and consequently in cognitive and memory functions which are mainly linked to the brain hippocampus. Thus there are various histopathological aspects of hippocampus, which are studied and discussed in this chapter. Additionally, the dose response relationship between EMF and biological effects are discussed in this chapter.

Keywords

Electromagnetic field Antioxidant enzyme Mitochondrial dysfunction CNS 

References

  1. Agarwal A, Durairajanayagam D (2015) Are men talking their reproductive health away? Asian J Androl 17:433–434Google Scholar
  2. Agarwal A, Singh A, Hamada A et al (2011) Cell phones and male infertility: a review of recent innovations in technology and consequences. Int Braz J Urol 37:432–454CrossRefGoogle Scholar
  3. Ahlbom A, Feychting M, Green A et al (2009) ICNIRP (International Commission for Non-Ionizing Radiation Protection) Standing Committee on Epidemiology. Epidemiologic evidence on mobile phones and tumor risk: a review. Epidemiology 20:639–652CrossRefGoogle Scholar
  4. Akdag MZ, Celik MS, Ketani A et al (1999) Effect of chronic low-intensity microwave radiation on sperm count, sperm morphology, and testicular and epididymal tissues of rats. Electro Magnetobiol 18:133–145Google Scholar
  5. Ammari M, Jacquet A, Lecomte A et al (2008) Effect of head-only sub-chronic and chronic exposure to 900-MHz GSM electromagnetic fields on spatial memory in rats. Brain Inj 22:1021–1029CrossRefGoogle Scholar
  6. Anger WK (1991) Animal test systems to study behavioral dysfunctions of neurodegenerative disorders. Neurotoxicol 12:403–413Google Scholar
  7. Antonsson B, Montessuit S, Lauper S et al (2000) Bax oligomerization is required for channelforming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem J 345:271–278CrossRefGoogle Scholar
  8. Baan R, Grosse Y, Lauby-Secretan B et al (2011) Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncol 12:624–626CrossRefGoogle Scholar
  9. Bagher Z, Shams AR, Farokhi M, Aghaei F (2008) Pyramidal cell damage in mouse brain after exposure to electromagnetic field. Iran J Neurol 7:142–148Google Scholar
  10. Barnett J, Timotijevic L, Shepherd R, Senior V (2007) Public responses to precautionary information from the Department of Health (UK) about possible health risks from mobile phones. Health Policy 82:240–250CrossRefGoogle Scholar
  11. Bas O, Odaci E, Mollaoglu H et al (2009) Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats. Toxicol Ind Health 25:377–384CrossRefGoogle Scholar
  12. Baureus KCL, Sommarin M, Persson BR et al (2003) Interaction between weak low frequency magnetic fields and cell membranes. Bioelectromagnetics 24:395–402CrossRefGoogle Scholar
  13. Baverstock K (2000) Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer. Mutat Res 454:89–109CrossRefGoogle Scholar
  14. Behari J (2009) Biological correlates of low-level electromagnetic-field exposure, general, applied and systems toxicology. Wiley, Book chapter 109. doi: 10.1002/9780470744307.gat171
  15. Bilici M, Efe H, Koroglu MA et al (2001) Antioxidative enzyme activities and lipid peroxidation in major depression; alteration by antidepressant treatments. J Affect Dis 64:43–51CrossRefGoogle Scholar
  16. Blackman CF, Benane SG, Elder JA et al (1980) Induction of calcium ion efflux from brain tissue by radiofrequency radiation: effect of sample number and modulation frequency on the power-density window. Bioelectromagnetics I:3S–43Google Scholar
  17. Bruel-Jungerman E, Davis S, Laroche S (2007) Brain plasticity mechanisms and memory: a party of four. Neuroscientist 13:492–505CrossRefGoogle Scholar
  18. Canu N, Calissano P (2003) In vitro cultured neurons for molecular studies correlating apoptosis with events related to Alzheimer disease. Cerebellum 2:270–278CrossRefGoogle Scholar
  19. Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527–605Google Scholar
  20. Chauhan P, Verma HN, Sisodia R, Kesari KK (2016) Microwave radiation (2.45 GHz) induced oxidative stress: whole body exposure effect on histopathology of Wistar rats. Electromagn Biol Med (in press) doi: 10.3109/15368378.2016.1144063
  21. Chou CK, Guy AW, McDougall J, Lai H (1985) Specific absorption rate in rats exposed to 2450-MHz microwaves under seven exposure conditions. Bioelectromagnetics 6:73–88CrossRefGoogle Scholar
  22. Christ A, Kuster N (2005) Differences in RF Energy absorption in the heads of adults and children. Bioelectromagnet Suppl 7:31–44CrossRefGoogle Scholar
  23. Ciani E, Groneng L, Voltattorni M et al (1996) Inhibition of free radical production of free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons. Brain Res 728:1–6CrossRefGoogle Scholar
  24. Cleary SF (1995) Reproductive toxic effects of electromagnetic radiation. In: Witorsch RJ (ed) Reproductive toxicology, 2nd edn. Raven, New York, pp 263–280Google Scholar
  25. Criswell KA, Krishna G, Zielinski D et al (1998) Use of acridine orange in: flow cytometric assessment of micronuclei induction. Mutat Res 414:63–75Google Scholar
  26. D’Andrea JA, Adair ER, de Lorge JO (2003) Behavioral and cognitive effects of microwave exposure. Bioelectromagnet Suppl 6:S39–S62CrossRefGoogle Scholar
  27. Dahal KP (2013) Mobile communication and its adverse effects. Himalayan Phys 4:51–59Google Scholar
  28. Daniels WMU, Pietersen CY, Carstens ME, Stein DJ (2004) Maternal separation in rats leads to anxiety behaviour, and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metab Brain Dis 19:13–24Google Scholar
  29. Dasdag S, Bilgin HM, Akdag MZ et al (2008) Effect of long term mobile phone exposure on oxidative-antioxidative processes and nitric oxide in rats. Biotechnol Biotechnol Equip 22:992–997CrossRefGoogle Scholar
  30. De-Iullis GN, Newey RJ, King BV et al (2009) Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro. PLoS ONE 4:e6446–e6454CrossRefGoogle Scholar
  31. Di Toro CG, Di Toro PA, Zieher LM, Guelman LR (2005) Sensitivity of cerebellar glutathione system to neonatal ionizing radiation exposure. Neurotoxicol 28:555–561CrossRefGoogle Scholar
  32. Digital Wireless Basics (DWB) (2007) Frequencies V Cellular, PCS, GSM, and Japanese Digital Cellular Frequencies. Accessed at www.privateline.com/PCS/Frequencies.htm
  33. Dimbylow PJ, Mann SM (1994) SAR calculations in an anatomically realistic model of the head for mobile communication transceivers at 900 MHz and 1.8 GHz. Phys Med Biol 39:1537–1544CrossRefGoogle Scholar
  34. Dudai Y (2004) The neurobiology of consolidations, or, how stable is the engram? Annu Rev Psychol 55:51–86CrossRefGoogle Scholar
  35. Ekert R, AD Tillotson D (1978) Potassium activation associated with intraneuronal free calcium. Science 200:437Google Scholar
  36. Falone S, Grossi MR, Cinque B, D’Angelo B, Tettamanti E (2007) Fifty hertz extremely low-frequency electromagnetic field causes changes in redox and differentiative status in neuroblastoma cells. Int J Biochem Cell Biol 39:2093–2106CrossRefGoogle Scholar
  37. Falone S, Mirabilio A, Carbone MC et al (2008) Chronic exposure to 50 Hz magnetic fields causes a significant weakening of antioxidant defence systems in aged rat brain. Int J Biochem Cell Biol 40:2762–2770CrossRefGoogle Scholar
  38. Feychting M, Jonsson F, Pedersen NL, Ahlbom A (2003) Occupational magnetic field exposure and neurodegenerative disease. Epidemiology 14:413–419Google Scholar
  39. Feychting M, Ahlbom A, Kheifet L (2005) EMF and health. Annu Rev Public Health 26:165–189CrossRefGoogle Scholar
  40. Fournier NM, Mach QH, Whissell PD, Persinger MA (2012) Neurodevelopmental anomalies of the hippocampus in rats exposed to weak intensity complex magnetic fields throughout gestation. Int J Dev Neurosci 30:427–433CrossRefGoogle Scholar
  41. Fu Y, Wang C, Wang J et al (2008) Long-term exposure to extremely low-frequency magnetic fields impairs spatial recognition memory in mice. Clin Exp Pharmacol Physiol 35:797–800CrossRefGoogle Scholar
  42. Gallagher M, Nicolle MM (1993) Animal models of normal aging: relationship between cognitive decline and markers in hippocampal circuitry. Behav Brain Res 57:155–162CrossRefGoogle Scholar
  43. Gandhi OP, Lazzi G, Furse CM (1996) Electromagnetic absorption in the human head and neck for mobile telephones at 835 and 1900 MHz. IEEE Trans Microwave Theor Tech 44:1884–1897CrossRefGoogle Scholar
  44. García AM, Sisternas A, Hoyos SP (2008) Occupational exposure toextremely low frequency electric and magnetic fields and Alzheimerdisease: a meta-analysis. Int J Epidemiol 37:329–340CrossRefGoogle Scholar
  45. Gilgun-Sherki Y, Melamed E, Offen D (2001) Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 40:959–975CrossRefGoogle Scholar
  46. Grassi C, D’Ascenzo M, Torsello A (2004) Effects of 50 Hz electromagnetic fields on voltage-gated Ca2+channels and their role in modulation of neuroendocrine cell proliferation and death. Cell Calcium 35:307–315CrossRefGoogle Scholar
  47. Guido K, John CR (2000) Mitochondrial control of cell death. Nat Med 6:513–519CrossRefGoogle Scholar
  48. Håkansson N, Gustavsson P, Johansen C, Floderus B (2003) Neurode-generative diseases in welders and other workers exposed to highlevels of magnetic fields. Epidemiology 14:420–426Google Scholar
  49. Harvey L, Arnold B, Lawrence Z et al (1999) Molecular cell biology, 4th ed. Publisher W.H. Freeman & Co Ltd; 4 Revised edition, pp 197–433Google Scholar
  50. Heim C, Owens MJ, Plotsky PM, Nemeroff CB (1997) The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor. Ann NY Acad Sci 821:194–207CrossRefGoogle Scholar
  51. Hongpaisan J, Alkon DL (2007) A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc Natl Acad Sci USA 104:19571–19576CrossRefGoogle Scholar
  52. Hossain H, Uma Devi P (2001) Effect of irradiation at the early foetal stage on adult brain function of mouse: learning and memory. Int J Rad Biol 77:581–585CrossRefGoogle Scholar
  53. Huang KP, Nakabayashi H, Huang FL (1986) Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase. Proc Natl Acad Sci USA 83:8535–8539CrossRefGoogle Scholar
  54. Hug K, Röösli M, Rapp R (2006) Magnetic field exposure and neurodegenerative diseases-recent epidemiological studies. Soz Praventivmed 51:210–220Google Scholar
  55. Huss A, Spoerri A, Egger M, Röösli M, Swiss National Cohort Study (2009) Residence near power lines and mortality from neuro-degenerative diseases: longitudinal study of the Swiss population. Am J Epidemiol 169:167–175Google Scholar
  56. IARC (2002) Non-ionizing radiation, Part 1: static and Extremely Low Frequency (ELF) electric and magnetic fields. In: IARC Monographs on the evaluation of carcinogenic risks to humans, vol 80. International Agency for Research on Cancer, LyonGoogle Scholar
  57. ICNIRP (1998) Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). Health Phys 74:494–522Google Scholar
  58. IEGMP (2000) Mobile phones and health. Report of an Independent Expert Group on Mobile Phones. Chilton, IEGMPGoogle Scholar
  59. Ivancsits S, Diem E, Pilger A et al (2002) Induction of DNA strand breaks by intermittent exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts. Mutat Res 519:1–13CrossRefGoogle Scholar
  60. Ivancsits S, Diem E, Jahn O, Rudiger HW (2003a) Intermittent extremely low frequency electromagnetic fields cause DNA damage in a dose-dependent way. Int Arch Occup Environ Health 76:431–436CrossRefGoogle Scholar
  61. Ivancsits S, Diem E, Jahn O, Rudiger HW (2003b) Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields. Mech Ageing Dev 124:847–850CrossRefGoogle Scholar
  62. Janać B, Tovilović G, Tomić M et al (2009) Effect of continuous exposure to alternating magnetic field (50 Hz, 0.5 mT) on serotonin and dopamine receptors activity in rat brain. Gen Physiol Biophys 28:41–46Google Scholar
  63. Janković SM, Milošev MZ, Novaković MLJ (2014) The effects of microwave radiation on microbial cultures. Hosp Pharmacol 1:102–108Google Scholar
  64. Jaworska A, Wojewodzka M, De Angelis P (2002) Radiation sensitivity and the status of some radiation sensitivity markers in relatively sensitive lymphoid cells. Radiats Biol Radioecol 42:595–599Google Scholar
  65. Jerman T, Kesner RP, Hunsaker MR (2006) Disconnection analysis of CA3 and DG in mediating encoding but not retrieval in a spatial maze learning task. Learn Mem 13:458–464CrossRefGoogle Scholar
  66. Kang XK, Li LW, Leong MS, Kooi PS (2001) A method of moments study of SAR inside spheroidal human head and current distribution among handset wireless antennas. J Electromag Waves Appl 15:61CrossRefGoogle Scholar
  67. Katsir G, Parola AH (1998) Enhanced proliferation caused by a low frequency weak magnetic field in chick embryo fibroblasts is suppressed by radical scavengers. Biochem Biophys Res Commun 252:753–756CrossRefGoogle Scholar
  68. Katz B, Milledi R (1967) The timing of calcium action during neuromuscular transmission. J Physiol (Lond) 189:535Google Scholar
  69. Keetley V, Wood AW, Spong J, Stough C (2006) Neuropsychological sequelae of digital mobile phone exposure in humans. Neuropsychologia 44:1843–1848CrossRefGoogle Scholar
  70. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257CrossRefGoogle Scholar
  71. Kesari KK, Behari J (2009) Fifty microwave exposure effect of radiations on rat brain. Appl Biochem Biotechnol 158:126–139CrossRefGoogle Scholar
  72. Kesari KK, Behari J (2010) Effect of microwave at 2.45 GHz radiations on reproductive system of male rats. Toxicol Environ Chem 92:1135–1147CrossRefGoogle Scholar
  73. Kesari KK, Behari J (2012) Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: role of ROS. Electromagn Biol Med 31:213–222CrossRefGoogle Scholar
  74. Kesari KK, Behari J, Kumar S (2010a) Mutagenic response of 2.45 GHz radiation exposure on rat brain. Int J Radiat Biol 86:334–343CrossRefGoogle Scholar
  75. Kesari KK, Kumar S, Behari J (2010b) Mobile phone usage and male infertility in Wistar rats. Indian J Exp Biol 48:987–992Google Scholar
  76. Kesari KK, Kumar S, Behari J (2011a) Effects of radiofrequency electromagnetic waves exposure from cellular phone on reproductive pattern in male Wistar rats. Appl Biochem Biotechnol 164:546–559CrossRefGoogle Scholar
  77. Kesari KK, Kumar S, Behari J (2011b) 900-MHz microwave radiation promotes oxidation in rat brain. Electromagn Biol Med 30:219–234CrossRefGoogle Scholar
  78. Kesari KK, Kumar S, Behari J (2012) Evidence for mobile phone radiation exposure effects on reproductive pattern of male rats: role of ROS. Electromagn Biol Med 31:213–222CrossRefGoogle Scholar
  79. Kesari KK, Kumar S, Nirala J et al (2013) Biophysical evaluation of radiofrequency electromagnetic field effects on male reproductive pattern. Cell Biochem Biophys 65:85–96CrossRefGoogle Scholar
  80. Kesari KK, Meena R, Nirala J et al (2014) Effect of 3G Cell Phone Exposure with Computer Controlled 2-D Stepper Motor on Non-Thermal Activation of the hsp27/p38MAPK Stress Pathway in Rat Brain. Cell Biochem Biophy 68:347–358CrossRefGoogle Scholar
  81. Kesari KK, Luukkonen J, Juutilainen J, Naarala J (2015) Genomic instability induced by 50 Hz magnetic fields is a dynamically evolving process not blocked by antioxidant treatment. Mutat Res Genet Toxicol Environ Mutagen 794:46–51CrossRefGoogle Scholar
  82. Kesari KK, Juutilainen J, Luukkonen J, Naarala J (2016) Induction of micronuclei and superoxide production in neuroblastoma and glioma cell lines exposed to weak 50 Hz magnetic fields. J R Soc Interface 13:1–10Google Scholar
  83. Khanzode SD, Dakhale GN, Khanzode SS (2003) Oxidative damage and major depression. Redox Rep 8:365–370CrossRefGoogle Scholar
  84. Khayyat LI, Abou-Zaid D (2009) The effect of isothermal non-ionizing electromagnetic field on the liver of mice. Egypt J Exp Biol (Zool) 5:93–99Google Scholar
  85. Kitaoka K, Kitamura M, Aoi S et al (2013) Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamic-pituitary-adrenal axis in mice. Bioelectromagnetics 34:43–51CrossRefGoogle Scholar
  86. Klann E, Sweatt JD (2008) Altered protein synthesis is a trigger for long-term memory formation. Neurobiol Learn Mem 89:247–259CrossRefGoogle Scholar
  87. Klur S, Muller C, Pereira de Vasconcelos A et al (2009) Hippocampal-dependent spatial memory functions might be lateralized in rats: an approach combining gene expression profiling and reversible inactivation. Hippocampus 19:800–816CrossRefGoogle Scholar
  88. Koivisto M, Revonsuo A, Krause C et al (2000) Effects of 902 MHz electromagnetic field emitted by cellular telephones on response times in humans. NeuroReport 11:413–415CrossRefGoogle Scholar
  89. Korkalainen M, Huumonen K, Naarala J et al (2012) Dioxininduces genomic instability in mouse embryonic fibroblasts. PLoS ONE 7:e37895CrossRefGoogle Scholar
  90. Kumar S, Kesari K, Behari J (2010a) The influence of microwave exposure on male fertility. Fertil Steril 95:1500–1502CrossRefGoogle Scholar
  91. Kumar S, Kesari KK, Behari J (2010b) Evaluation of genotoxic effects in male Wistar rats following microwave exposure. Indian J Exp Biol 48:586–592Google Scholar
  92. Kumar S, Kesari KK, Behari J (2011) Synergistic effect of 2.45 GHz and pulsed magnetic field on reproductive pattern of male Wistar rats. Clinics (Sao Paulo) 66:1237–1245CrossRefGoogle Scholar
  93. Kumar S, Nirala JP, Behari J et al (2014) Effect of electromagnetic irradiation produced by 3G mobile phone on male rat reproductive system in a simulated scenario. Indian J Exp Biol 52:890–897Google Scholar
  94. Kumari K, Meena R, Kumar S et al (2012) Radiofrequency electromagnetic field exposure effects on antioxidant enzymes and liver function tests. LS Int J Life Sci 1:233–239CrossRefGoogle Scholar
  95. Kunjilwar KK, Behari J (1993) Effect of amplitude-modulated radio frequency radiation on cholinergic system of developing rats. Brain Res 601:321–324CrossRefGoogle Scholar
  96. Lai H (1994) Neurological effects of microwave irradiation. In: Lin JC (ed) Advances in electromagnetic fields in living systems, vol 1. Plenum Press, New York, pp 27–80CrossRefGoogle Scholar
  97. Lai H, Singh NP (1995) Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells. Bioelectromagnetics 16:207–210Google Scholar
  98. Lai H (2002) Neurological effects of radiofrequency electromagnetic, EMF-Scientific and legal Issues, Theory and Evidence of EMF Biological and Health Effects in Catania, Sicily, Italy, Sept 13–14Google Scholar
  99. Lee I, Solivan F (2008) The roles of the medial prefrontal cortex and hippocampus in a spatial paired-association task. Learn Mem 15:357–367CrossRefGoogle Scholar
  100. Li P, Nijhawan D, Budihardjo I et al (1997) Cytochrome c and dATPdependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479–489CrossRefGoogle Scholar
  101. Liu X, Kim CN, Yang J et al (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86:147–157CrossRefGoogle Scholar
  102. Liu R, Liu W, Doctrow SR, Baudry M (2003) Iron toxicity in organotypic cultures of hippocampal slices: role of reactive oxygen species. J Neurochem 85:492–502CrossRefGoogle Scholar
  103. Liu T, Wang S, He L, Ye K (2008) Chronic exposure to low intensity magnetic field improves acquisition and maintenance of memory. NeuroReport 19:549–552CrossRefGoogle Scholar
  104. Llinas R, Nicholson C (1975) Calcium role in depolarization-secretion coupling: an aequorin study in squid giant-synapse. Proc Natl Acad Sci USA 72:187Google Scholar
  105. Luukkonen J, Liimatainen A, Juutilainen J, Naarala J (2014) Induction of genomicinstability, oxidative processes, and mitochondrial activity by 50 Hz magneticfields in human SH-SY5Y neuroblastoma cells. Mutat Res/Fundam Mol Mech Mutagen 760:33–41CrossRefGoogle Scholar
  106. Lyskov EB, Aleksanian ZA, Iousmiaki V et al (1993a) Neurophysiologic effects of short-term exposure to ultra-low-frequency magnetic field. Fiziol Cheloveka 19:121–125Google Scholar
  107. Lyskov EB, Juutilainen J, Jousmaki V et al (1993b) Effects of 45-Hz magnetic fields on the functional state of the human brain. Bioelectromagnetics 14:87–95CrossRefGoogle Scholar
  108. Lyskov E, Sandstrom M, Mild KH (2001) Provocation study of persons with perceived electrical hypersensitivity and controls using magnetic field exposure and recording of electrophysiological characteristics. Bioelectromagnetics 22:45CrossRefGoogle Scholar
  109. Manikonda PK, Rajendra P, Devendranath D et al (2007) Influence of extremely low frequency magnetic fields on Ca2+ signaling and NMDA receptor functions in rat hippocampus. Neurosci Lett 413:145–149Google Scholar
  110. Marino AA, Kolomytkin OV, Frilot C (2003) Extracellular currents alter gap junction intercellular communication in synovial fibroblasts. Bioelectromagnetics 24:199–205CrossRefGoogle Scholar
  111. Marzatico F, Porta C, Moroni M et al (2000) In vitro antioxidant properties of amifostine (WR-2721, Ethyol). Cancer Chemother Pharmacol 45:172–176CrossRefGoogle Scholar
  112. Maskey D, Kim M, Aryal B et al (2010) Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain. Brain Res 1313:232–241CrossRefGoogle Scholar
  113. Masuda H, Hirata A, Kawai H et al (2011) Local exposure of the rat cortex to radiofrequency electromagnetic fields increases local cerebral blood flow along with temperature. J Appl Physiol 110:142–148CrossRefGoogle Scholar
  114. Mattson MP, Magnus T (2006) Ageing and neuronal vulnerability. Nat Rev Neurosci 7:278–294CrossRefGoogle Scholar
  115. Mausset AL, de Seze R, Montpeyroux F, Privat A (2001) Effects of radiofrequency exposure on the GABAergic system in the rat cerebellum: clues from semiquantitative immunohistochemistry. Brain Res 912:33–46CrossRefGoogle Scholar
  116. Meena R, Kajal K, Kumar J et al (2014) Therapeutic approaches of melatonin in microwave radiations induced oxidative stress mediated toxicity on male fertility pattern of Wistar rats. Electromagn Biol Med 33:81–91CrossRefGoogle Scholar
  117. Migliore L, Coppedè F, Fenech M, Thomas P (2011) Association of micronucleus frequency with neurodegenerative diseases. Mutagenesis 26:85–92CrossRefGoogle Scholar
  118. Miranda R, Blanco E, Begega A et al (2006) Hippocampal and caudate metabolic activity associated with different navigational strategies. Behav Neurosci 120:641–650CrossRefGoogle Scholar
  119. Moghimi A, Baharara J, Musavi SS (2009) Effect of mobile phone microwaves on fetal period of BALB/c mice in histological characteristics of hippocampus and learning behaviors. Iran J Basic Med Sci 150:150–157Google Scholar
  120. Morgane PJ, Austi- Lafrance RJ, Bronzino JD et al (1992) Malnutrition and the developing central nervous system. In: Issacson RL, Jensen KF (eds) The vulnerable brain and environmental risks, vol 1: Malnutrition and hazard assessment. Plenum, New York, pp 3–44Google Scholar
  121. Morris RGM (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47–60CrossRefGoogle Scholar
  122. Morris RGM, Garrud P, Rawlins JNP, O’Keefe J (1982) Place navigation is impaired in rats with hippocampal lesions. Nature 297:681–683CrossRefGoogle Scholar
  123. Muchmore SW, Sattler M, Liang H et al (1996) X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381:335–341CrossRefGoogle Scholar
  124. Narayanan SN, Kumar RS, Potu BK et al (2009) Spatial memory perfomance of wistar rats exposed to mobile phone. Clinics 64:231–234CrossRefGoogle Scholar
  125. Newmeyer DD, Farschon DM, Reed JC (1994) Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell 79:353–364CrossRefGoogle Scholar
  126. Newton AC (1995) Protein-kinase-C—structure, function, and regulation. J Biol Chem 270:28495–28498CrossRefGoogle Scholar
  127. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607–614CrossRefGoogle Scholar
  128. Oktem F, Ozguner F, Mollaoglu H et al (2005) Oxidative damage in the kidney induced by 900 MHz emitted mobile phone: protection by melatonin. Arch Med Res 36:350–355CrossRefGoogle Scholar
  129. Olton DS, Samuelson RJ (1976) Remembrance of places past—spatial memory in rats. J Exp Psychol Anim Behav Process 2:97–116CrossRefGoogle Scholar
  130. Papageorgiou CC, Nanou ED, Tsiafakis VG, Kapareliotis E, Kontoangelos KA, Capsalis CN, Rabavilas AD, Soldatos CR (2006) Acute mobile phone effects on pre-attentive operation. Neurosci Lett F397:99–103Google Scholar
  131. Parker PJ, Stabel S, Waterfield MD (1984) Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor. EMBO J 3:953–959Google Scholar
  132. Paulraj R, Behari J (2006) Single strand DNA breaks in rat brain cells exposed to microwave radiation. Mutat Res 596:76–80CrossRefGoogle Scholar
  133. Paulraj R, Behari J, Rao AR (1999) Effect of amplitude modulated RF radiation on calcium ion efflux and ODC activity in chronically exposed rat brain. Indian J Biochem Biophys 36:337–340Google Scholar
  134. Petito CK, Halaby IA (1993) Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic protein. Int J Dev Neurosci 11:239–247CrossRefGoogle Scholar
  135. Pirozzoli M, Marino C, Lovisolo G (2003) Effects of 50 Hz electromagnetic field exposure on apoptosis and differentiation in a neuroblastoma cell line. Bioelectromagnetics 24:510–516CrossRefGoogle Scholar
  136. Polyashuck L (1971) Changes in permeability of histo-hematic barriers under the effect of microwaves. Dokl Akad Nauk Ukr 8:754–758Google Scholar
  137. Przedborski SE (2003) Program project on the pathogenesis and treatment of parkinson’s disease. Report of Columbia University New York, NY 10032Google Scholar
  138. Rachael UM (2010) Somatic and genetic effects of low SAR 2.45 GHz microwave radiation on Wistar rats. Ph.D. thesis, School of Post Graduate Studies of Covenant University, Ota, pp 1Google Scholar
  139. Rao VS, Titushkin IA, Moros EG et al (2008) Nonthermal effects of radiofrequency-field exposure on calcium dynamics in stem cell-derived neuronal cells: elucidation of calcium pathways. Radiat Res 169:319–329CrossRefGoogle Scholar
  140. Ravera S, Bianco B, Cugnoli C et al (2010) Sinusoidal ELF magnetic fields affect acetylcholinesterase activity in cerebellum synaptosomal membranes. Bioelectromagnetics 31:270–276CrossRefGoogle Scholar
  141. Regoli F, Gorbi S, Machella N et al (2005) Pro-oxidant effects of extremely low frequency electromagnetic fields in the land snail Helix aspersa. Free Radical Biol Med 39:1620–1628CrossRefGoogle Scholar
  142. Rolls ET, Kesner RP (2006) A computational theory of hippocampal function, and empirical tests of the theory. Prog Neurobiol 79:1–48CrossRefGoogle Scholar
  143. Röösli M, Lörtscher M, Egger M et al (2007) Leukaemia, brain tumours and exposure to extremely low frequency magnetic fields: cohort study of Swiss railway employees. Occup Environ Med 64:553–559CrossRefGoogle Scholar
  144. Rothman KJ, Chou CK, Morgan R et al (1996) Assessment of cellular telephone and other radio frequency exposure for epidemiologic research. Epidemiology 7:291–298CrossRefGoogle Scholar
  145. Roxanne N (2009) Cell phones and brain cancer—jury still out (Online). Available: URL http://medscape.com
  146. Saito M, Korsmeyer SJ, Schlesinger PH (2000) BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2:553–555CrossRefGoogle Scholar
  147. Salford LG, Brun AE, Eberhardt JL (2003) Nerve cell damage in mammalian brain after exposure to microwaves from GSM mobile phones. Environ Health Perspect 111:881–883CrossRefGoogle Scholar
  148. Salunke BP, Umathe SN, Chavan JG (2013) Low frequency magnetic field induces depression by rising nitric oxide levels in the mouse brain. Int J Res Dev Pharm Life Sci 2:439–450Google Scholar
  149. Schapira AH, Cleeter MW, Muddle JR et al (2006) Proteasomal inhibition causes loss of nigral tyrosine hydroxylase neurons. Ann Neurol 60:253–255CrossRefGoogle Scholar
  150. Schrader SM, Karnity MH (1994) Occupational hazards to male reproductive in state of the art reviews in occupational medicine: preproductive hazards. In: Gold E, Schenker M, Leskey B (eds). Hanley and Belfus, Philadelphia, PA, pp 405–414Google Scholar
  151. Scott D, Hu Q, Roberts SA (1996) Dose-rate sparing for micronucleus induction in lymphocytes of controls and ataxia-telangiectasia heterozygotes exposed to 60Co gamma-irradiation in vitro. Int J Radiat Biol 70:521–527CrossRefGoogle Scholar
  152. Seeman P (1972) The membrane action of anesthetics and tranquilizers. Pharmacol Rev 24:583Google Scholar
  153. Shanes AM (1958) Electrochemical aspects of physiological ad pharmacological action in excitable cells. Pharmacol Rev 10:59Google Scholar
  154. Sharma A, Sisodia R, Bhatnagar D, Saxena VK (2014) Spatial memory and learning performance and its relationship to protein synthesis of Swiss albino mice exposed to 10 GHz microwaves. Int J Rad Biol 90:29–35CrossRefGoogle Scholar
  155. Sharma A, Kesari KK, Saxena VK, Sisodia R (2016) The influence of prenatal 10 GHz microwave radiation exposure on a developing mice brain. Gen Phys Biophys [Epub ahead of print]. Doi: 10.4149/gpb_2016026
  156. Shigenaga MK, Hagen TM, Ames BN (1994) Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A 91:10771–10778CrossRefGoogle Scholar
  157. Simko M, Mattsson MO (2004) Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: Possible immune cell activation. J Cell Biochem 93:83–92CrossRefGoogle Scholar
  158. Sisodia R, Singh S (2009) Biochemical, behavioral and quantitative alterations in cerebellum of Swiss albino mice following irradiation and its modulation by Grewia asiatica. Int J Rad Biol 85:787–795CrossRefGoogle Scholar
  159. Sonmez OF, Odaci E, Bas O, Kaplan S (2010) Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field. Brain Res 1356:95–101CrossRefGoogle Scholar
  160. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998) Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1:949–957CrossRefGoogle Scholar
  161. Stabel S, Parker PJ (1991) Protein kinase C. Pharmacol Ther 51:71–95CrossRefGoogle Scholar
  162. Stefanics G, Kellényi L, Molnár F et al (2007) Short GSM mobile phone exposure does not alter human auditory brainstem response. BMC Public Health 7:325Google Scholar
  163. Szemerszky R, Zelena D, Barna I, Bárdos G (2010) Stress-related endocrinological and psychopathological effects of short- and long-term 50 Hz electromagnetic field exposure in rats. Brain Res Bull 81:92–99CrossRefGoogle Scholar
  164. Takai Y, Kishimoto A, Inoue M et al (1977) Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues I: purification and characterization of an active enzyme from bovine cerebellum. J Biol Chem 252:7603–7609Google Scholar
  165. TECH (2007) How cell-phone radiation works. Available at: http://www.howstuffworks.com/cell-phone-radiation.htm
  166. Thomas P, Harvey S, Gruner T, Fenech M (2007) The buccal cytome and micronucleus frequency is substantially altered in Down’s syndrome and normal ageing compared to young healthy controls. Mutat Res 638:37–47CrossRefGoogle Scholar
  167. Trippi F, Botto N, Scarpato R, Petrozzi L, Bonucelli U, Latorraca S, Sorbi S, Migliore L (2001) Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer’s disease patients. Mutagenesis 16:323–327Google Scholar
  168. UNSCEAR (2000) United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and Effects of Ionizing Radiation. Report to the General Assembly, vol II: Effects. United Nations, New YorkGoogle Scholar
  169. Uttara B, Singh AV, Zamboni P, Mahajan RT (2009) Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 7:65–74CrossRefGoogle Scholar
  170. Vago D, Kesner RP (2005) An electrophysiological and behavioral characterization of the temporoammonic pathway: disruption produces deficits in retrieval and spatial mismatch. In: Society for Neuroscience 35th Annual Meeting; Washington, DCGoogle Scholar
  171. Verschaeve L (2009) Genetic damage in subjects exposed to radiofrequency radiation. Mutat Res 681:259–270CrossRefGoogle Scholar
  172. Vral A, Thierens H, De Ridder L (1996) Micronucleus induction by 60Co gamma-rays and fast neutrons in ataxia telangiectasia lymphocytes. Int J Radiat Biol 70:171–176CrossRefGoogle Scholar
  173. Wang X, Liu Y, Lei Y et al (2008) Extremely low-frequency electromagnetic field exposure during chronic morphine treatment strengthens downregulation of dopamine D2 receptors in rat dorsal hippocampus after morphine withdrawal. Neurosci Lett 433:178–182CrossRefGoogle Scholar
  174. Wolf FI, Torsello A, Tedesco B et al (2005) 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: possible involvement of a redox mechanism. Biochim Biophys Acta 1743:120–129CrossRefGoogle Scholar
  175. Wyde M, Cesta M, Blystone C et al (2016) Report of Partial Findings from the National Toxicology Program Carcinogenesis Studies of Cell Phone Radiofrequency Radiation in Hsd: Sprague Dawley® SD rats (Whole Body Exposures). Draft 5-19-2016. US National Toxicology Program (NTP) doi:http://dx.doi.org/10.1101/055699
  176. Zare S, Alivandi S, Ebadi AG (2007) Histological studies of the low frequency electromagnetic fields effect on liver, testes and kidney in guinea pig. World Appl Sci J 2:509–511Google Scholar
  177. Zoratti M, Szabo I, De Marchi U (2005) Mitochondrial permeability transitions: how many doors to the house? Biochim Biophys Acta 1706:40–52CrossRefGoogle Scholar
  178. Zwirska-Korczala K, Jochem J, Adamczyk-Sowa M et al (2005) Effect of extremely low frequency of electromagnetic fields on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes—an in vitro study. J Physiol Pharmacol 56:101–108Google Scholar

Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Archana Sharma
    • 1
  • Kavindra Kumar Kesari
    • 2
    • 3
  • H. N. Verma
    • 2
  • Rashmi Sisodia
    • 1
  1. 1.Department of ZoologyUniversity of RajasthanJaipurIndia
  2. 2.Department of Engineering and TechnologyJaipur National UniversityJaipurIndia
  3. 3.Department of Environmental and Biological SciencesUniversity of Eastern FinlandKuopioFinland

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