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Current Imaging Strategies for Patient Selection in Acute Ischemic Stroke Trials

  • Jenny P. Tsai
  • Gregory W. AlbersEmail author
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Abstract

Neuroimaging is an important part of acute ischemic stroke trials. Its key components include vascular, ischemic core, and penumbral imaging. These can be acquired by two modalities: computed tomography (CT) and magnetic resonance imaging (MRI). This chapter provides an overview of common CT- and MRI-based angiographic, parenchymal, and perfusion imaging techniques, and their roles in patient selection in acute ischemic stroke trials.

Keywords

Computed tomography Computed tomography angiography Computed tomography perfusion Magnetic resonance angiography Diffusion-weighted imaging Perfusion-weighted imaging Arterial spin labeling ASPECT score 

Abbreviations

ADC

Apparent diffusion coefficient

AHA/ASA

American Heart Association/American Stroke Association

ASL

Arterial spin labeling

ASPECTS

Alberta Stroke Program Early Computed Tomography Score

CBF

Cerebral blood flow

CBV

Cerebral blood volume

CT

Computed tomography

CTA

Computed tomography angiography

CTP

Computed tomography perfusion imaging

DEDAS

Dose Escalation of Desmoteplase for Acute Ischemic Stroke trial

DEFUSE

Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution study

DIAS

Desmoteplase In Acute Stroke trial

DWI

Diffusion-weighted imaging

EPITHET

Echoplanar Imaging Thrombolytic Evaluation trial

EXTEND

EXtending the time for Thrombolysis in Emergency Neurological Deficits trial

FLAIR

Fluid-attenuated inversion recovery sequence

IMS-III

Interventional Management of Stroke-III trial

kVp

Peak kilovoltage

mAs

Milliamps per second

MCA

Middle cerebral artery

MIP

Maximal intensity projection

MP-CTA

Multiphase computed tomography angiography

MRA

Magnetic resonance angiography

MRI

Magnetic resonance imaging

mSv

Millisievert

MTT

Mean transit time

NCCT

Noncontrast computed tomography

PWI

Perfusion-weighted imaging

SNR

Signal-to-noise ratio

Tmax

Time-to-maximum of the residue function

TOF

Time-of-flight

tPA

Tissue plasminogen activator

TTP

Time-to-peak

VERiTAS

Vertebrobasilar Flow Evaluation and Risk in Transient Ischemic Attack and Stroke study

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of NeurologyStanford UniversityStanfordUSA

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