The Role of Atrial Functional Assessment in Heart Failure

Chapter

Abstract

Cardiac remodelling is a fundamental part of the heart failure syndrome, representing a common response to various pathological stimuli that result in changes in the structural and functional properties of the heart. To date, most studies in HF have focused on ventricular remodelling, and much less emphasis has been placed on atrial structural and functional changes. In reality, the left atrium modulates left ventricular filling by acting as an elastic reservoir, passive conduit, and active booster. Left atrial dysfunction and remodelling are commonly observed in patients with heart failure and altered LA diastolic and systolic properties may influence cardiac filling and output.

Recently, thanks to the development of proper technology for LA function assessment (speckle tracking echo), there is increasing recognition of the importance of LA functional assessment in heart failure patients. LA evaluation remains crucial in the prediction of the development of heart failure, irrespectively of systolic function. If heart failure is established, atrial size and function appear to be powerful predictor of clinical outcomes.

Keywords

Atrial function Heart failure Echocardiography Left atrial strain Prognosis 

Abbreviations

AF

Atrial fibrillation

CT

Computed tomography

HF

Heart failure

HFpEF

Heart failure with preserved ejection fraction

HFrEF

Heart failure with reduced ejection fraction

LA

Left atrium/left atrial

LAEF

Left atrial emptying fraction

LV

Left ventricle/left ventricular

LVEF

Left ventricular ejection fraction

MRI

Magnetic resonance imaging

PALS

Peak atrial longitudinal strain

RV

Right ventricle/right ventricular

STE

Speckle tracking echocardiography

TDI

Tissue Doppler imaging

References

  1. 1.
    Blume GG, Mcleod CJ, Barnes ME, Seward JB, Pellikka PA, Bastiansen PM, Tsang TRM. Left atrial function: physiology, assessment, and clinical implications. Eur J Echocardiogr. 2011;12:421–30.CrossRefPubMedGoogle Scholar
  2. 2.
    Cameli M, Lisi M, Righini FM, Mondillo S. Novel echocardiographic techniques to assess left atrial size, anatomy and function. Cardiovasc Ultrasound. 2012;10:4.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    DY L, Boyd A, AA N, Chi C, Thomas L. Echocardiographic evaluation of left atrial size and function: current understanding, pathophysiologic correlates, and prognostic implications. Am Heart J. 2008;156(6):1056–64.CrossRefGoogle Scholar
  4. 4.
    Shah AM, Lam CSP. Function over form? assessing the left atrium in heart failure. Eur Heart J. 2015;36:711–4.CrossRefPubMedGoogle Scholar
  5. 5.
    Stefanadis C, Dernellis J, Toutouzas PA. Clinical appraisal of left atrial function. Eur Heart J. 2001;22:22–36.CrossRefPubMedGoogle Scholar
  6. 6.
    Triposkiadis F, Tentolouris K, Androulakis A, Trikas A, Toutouzas K, Kyriakidis M, et al. Left atrial mechanical function in the healthy elderly: new insights from a combined assessment of changes in atrial volume and transmitral flow velocity. J Am Soc Echocardiogr. 1995;8:801–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Itoh T, Okamoto H, Nimi T, Morita S, Sawazaki M, Ogawa Y, et al. Left atrial function after cox’s maze operation concomitant with mitral valve operation. Ann Thorac Surg. 1995;60:354–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Kurt M, Wang J, Torre-Amione G, Nagueh SF. Left atrial function in diastolic heart failure. Circ Cardiovasc Imaging. 2009;2:10–5.CrossRefPubMedGoogle Scholar
  9. 9.
    Murata M, Iwanaga S, Tamura Y, Kondo M, Kouyama K, Murata M, Ogawa S. Real-time three-dimensional echocardiographic quantitative analysis of left ventricular diastolic dysfunction. Am J Cardiol. 2008;8:1097–102.CrossRefGoogle Scholar
  10. 10.
    Pagel PS, Kehl F, Gare M, et al. Mechanical function of the left atrium: new insights based on analysis of pressure-volume relations and Doppler echocardiography. Anesthesiology. 2003;98:975–94.CrossRefPubMedGoogle Scholar
  11. 11.
    Lupu S, Mitre A, Dobreanu D. Left atrium function assessment by echocardiography – physiological and clinical implications. Med Ultrason. 2014;16(2):152–9.CrossRefPubMedGoogle Scholar
  12. 12.
    Iuchi A, Oki T, Tabata T, Manabe K, Kageji Y, Sasaki M, et al. Changes in pulmon- ary venous and transmitral flow velocity patterns after cardioversion of atrial fibrillation. J Cardiol. 1995;25:317–24.PubMedGoogle Scholar
  13. 13.
    Basnight MA, Gonzalez MS, Kershenovich SC, Appleton CP. Pulmonary venous flow velocity: relation to hemodynamics, mitral flow velocity and left atrial volume, and ejection fraction. J Am Soc Echocardiogr. 1991;4:547–58.CrossRefPubMedGoogle Scholar
  14. 14.
    CM Y, Fung JW, Zhang Q, Kum LC, Lin H, Yip GW, et al. Tissue Doppler echo- cardiographic evidence of atrial mechanical dysfunction in coronary artery disease. Int J Cardiol. 2005;105:178–85.CrossRefGoogle Scholar
  15. 15.
    Cameli M, Caputo M, Mondillo S, Ballo P, Palmerini E, Lisi M, Marino E, Galderisi M. Feasibility and reference values of left atrial longitudinal strain imaging by two-dimensional speckle tracking. Cardiovasc Ultrasound. 2009. doi: 10.1186/1476-7120-7-6. PubMedPubMedCentralGoogle Scholar
  16. 16.
    Hoit BD. Left atrial size and function: role in prognosis. J Am Coll Cardiol. 2014;63:493–505.CrossRefPubMedGoogle Scholar
  17. 17.
    Kim DG, Lee KJ, Lee S, Jeong SY, Lee YS, Choi YJ, Yoon HS, Kim JH, Jeong KT, Park SC, Park M. Feasibility of two-dimensional global longitudinal strain and strain rate imaging for the assessment of left atrial function: a study in subjects with a low probability of cardiovascular disease and normal exercise capacity. Echocardiography. 2009;26:1179–87.CrossRefPubMedGoogle Scholar
  18. 18.
    Saraiva RM, Demirkol S, Buakhamsri A, Greenberg N, Popović ZB, Thomas JD, Klein AL. Left atrial strain measured by two-dimensional speckle tracking represents a new tool to evaluate left atrial function. J Am Soc Echocardiogr. 2010;23:172–80.CrossRefPubMedGoogle Scholar
  19. 19.
    Okamatsu K, Takeuchi M, Nakai H, Nishikage T, Salgo IS, Husson S, Otsuji Y, Lang RM. Effects of aging on left atrial function assessed by two-dimensional speckle tracking echocardiography. J Am Soc Echocardiogr. 2009;22:70–5.CrossRefPubMedGoogle Scholar
  20. 20.
    Di Salvo G, Pacileo G, Castaldi B, Gala S, Morelli C, D’Andrea A, Limongelli G, Del Gaizo F, Merlino E, Russo MG, Calabrò R. Two-dimensional strain and atrial function: a study on patients after percutaneous closure of atrial septal defect. Eur J Echocardiogr. 2009;10:256–9.CrossRefPubMedGoogle Scholar
  21. 21.
    Kokubu N, Yuda S, Tsuchihashi K, Hashimoto A, Nakata T, Miura T, Ura N, Nagao K, Tsuzuki M, Wakabayashi C, Shimamoto K. Noninvasive assessment of left atrial function by strain rate imaging in patients with hypertension: a possible benificial effect of renin-angiotensin system inhibition on left atrial function. Hypertens Res. 2007;30:13–21.CrossRefPubMedGoogle Scholar
  22. 22.
    Pellicori P, Zhang J, Lukaschuk E, Joseph AC, Bourantas CV, Loh H, Bragadeesh T, Clark AL, Cleland JGF. Left atrial function measured by cardiac magnetic resonance imaging in patients with heart failure: clinical associations and prognostic value. Eur Heart J. 2015;36:733–42.CrossRefPubMedGoogle Scholar
  23. 23.
    Donal E, Raud-Raynier P, DePlace C, Gervais R, Rosier A, Roulaud M, Ingels A, Carre F, Daubert JC, Denjean A. Resting echocardiographic assessments of left atrial function and filling pressure interest in the understanding of exercise capacity in patients with chronic congestive heart failure. J Am Soc Echocardiogr. 2008;21:703–10.CrossRefPubMedGoogle Scholar
  24. 24.
    Welles CC, IA K, Kwan DM, Whooley MA, Schiller NB, Turakhia MP. Left atrial function predicts heart failure hospitalization in subjects with preserved ejection fraction and coronary heart disease: longitudinal data from the Heart and Soul Study. J Am Coll Cardiol. 2012;59:673–80.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Tan YT, Wenzelburger F, Lee E, Nightingale P, Heatlie G, Leyva F, Sanderson JE. Reduced left atrial function on exercise in patients with heart failure and normal ejection fraction. Heart. 2010;96:1017–23.CrossRefPubMedGoogle Scholar
  26. 26.
    Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA. Cardiovascular features of heart fail- ure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodelling/dysfunction. J Am Coll Cardiol. 2007;49:198–207.CrossRefPubMedGoogle Scholar
  27. 27.
    Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA. Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study). Am J Cardiol. 2006;97:83–9.CrossRefPubMedGoogle Scholar
  28. 28.
    Olsson LG, Swedberg K, Ducharme A, Granger CB, Michelson EL, McMurray JJ, Puu M, Yusuf S, Pfeffer MA, Investigators CHARM. Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: results from the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) program. J Am Coll Cardiol. 2006;47:1997–2004.CrossRefPubMedGoogle Scholar
  29. 29.
    Mondillo S, Cameli M, Caputo ML, Lisi M, Palmerini E, Padeletti M, Ballo P. Early detection of left atrial strain abnormalities by speckle-tracking in hypertensive and diabetic patients with normal left atrial size. J Am Soc Echocardiogr. 2011;24:898–908.CrossRefPubMedGoogle Scholar
  30. 30.
    Wakami K, Ohte N, Asada K, Fukuta H, Goto T, Mukai S, Narita H, Kimura G. Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole. J Am Soc Echocardiogr. 2009;22:847–51.CrossRefPubMedGoogle Scholar
  31. 31.
    Cameli M, Lisi M, Mondillo S, Padeletti M, Ballo P, Tsioulpas C, Bernazzali S, Maccherini M. Left atrial longitudinal strain by speckle tracking echocardiography correlates well with left ventricular filling pressures in patients with heart failure. Cardiovasc Ultrasound. 2010;8:14.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Cameli M, Sparla S, Losito M, Righini FM, Menci D, Lisi M, D’Ascenzi F, Focardi M, Favilli R, Pierli C, Fineschi M, Mondillo S. Correlation of left atrial strain and Doppler measurements with invasive measurement of left ventricular end-diastolic pressure in patients stratified for different values of ejection fraction. Echocardiography. 2016;33(3):398–405.CrossRefPubMedGoogle Scholar
  33. 33.
    Mullens W, Borowski A, Curtin R, Thomas J, Tang W. Tissue Doppler imaging in the estimation of intracrdiac filling pressure in decompensated patients with advanced systolic heart failure. Circulation. 2009;119:62–70.CrossRefPubMedGoogle Scholar
  34. 34.
    Cameli M, Mandoli GE, Loiacono F, Dini FL, Henein M, Mondillo S. Left atrial strain: a new parameter for assessment of left ventricular filling pressure. Heart Fail Rev. 2016;21(1):65–76.CrossRefPubMedGoogle Scholar
  35. 35.
    Yamamoto T, Oki T, Yamada H, Tanaka H, Ishimoto T, Wakatsuki T, Tabata T, Ito S. Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction. J Am Soc Echocardiogr. 2003;16:333–9.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Cardiovascular DiseasesUniversity of SienaSienaItaly

Personalised recommendations