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Melanonychias pp 111-118 | Cite as

Histological Analysis of the Nail Plate in the Diagnosis of Melanonychia and Other Nail Pigmentation

  • Beth S. Ruben
Chapter

Abstract

  • Melanocytic activation is a common cause of pigmentation of the nail plate and consists of melanin production without a proliferation of melanocytes.

  • Melanocytic proliferations (lentigo, nevi, and melanoma) often produce a solitary longitudinal pigmented band.

  • Other causes of nail plate pigmentation: pigmented squamous cell carcinoma, pigmented onychomatricoma, onychocytic matricoma, pigmented onychomycosis, and nail plate hemorrhage.

  • Nail clipping can serve as a less invasive screening procedure for identifying the cause of nail plate discoloration.

  • Fontana–Masson staining is useful in identifying melanin.

  • Benzidine stain can be used to identify hemoglobin.

Keywords

Prussian Blue Nail Plate Melanin Production Nail Sampling Melanin Pigmentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Dermatopathology ServicePalo Alto Medical FoundationPalo AltoUSA

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