Fat and Stem-Cells

  • Mario Goisis
  • Ribó Planas
  • Muñoz del Olmo
  • Sara Izzo
  • Andrea Sbarbati
  • Giamaica Conti


Human mesenchymal stem-cells (hMSCs) have multipotent differentiation properties. These cells can be obtained from different areas including bone marrow (hBMSCs), dental pulp, umbilical-cord blood, synovial membrane, placenta, the skin, the umbilical cord, skeletal muscle, Wharton’s jelly, the meniscus, mother’s milk, cartilage, ligament, and adipose tissue (ASCs). A great number of applications of hMSCs have been described in literature.


  1. 1.
    Bianchi F, Maioli M, Leonardi E, Olivi E, Pasquinelli G, Valente S, Mendez AJ, Ricordi C, Raffaini M, Tremolada C, Ventura C. A new nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates. Cell Transplant. 2013;22(11):2063–77.CrossRefGoogle Scholar
  2. 2.
    Ventura C, Cantoni S, Bianchi F, Lionetti V, Cavallini C, Scarlata I, Foroni L, Maioli M, Bonsi L, Alviano F, Fossati V, Bagnara GP, Pasquinelli G, Recchia FA, Perbellini A. Hyaluronan mixed esters of butyric and retinoic acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance cardiac repair in infarcted rat hearts. J Biol Chem. 2007;282(19):14243–52.CrossRefGoogle Scholar
  3. 3.
    Cavallari G, Olivi E, Bianchi F, Neri F, Foroni L, Valente S, Manna GL, Nardo B, Stefoni S, Ventura C. Mesenchymal stem cells and islet cotransplantation in diabetic rats: improved islet graft revascularization and function by preconditioned with natural molecules. Cell Transplant. 2012;21(12):2771–81.CrossRefGoogle Scholar
  4. 4.
    Stavely R, Robinson AM, Miller S, Boyd R, Sakkal S, Nurgali K. Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis. Stem Cell Res Ther. 2015;6(1):244.CrossRefGoogle Scholar
  5. 5.
    Wang W, He N, Feng C, Liu V, et al. Human adipose-derived mesenchymal progenitor cells engraft into rabbit articular cartilage. Int J Mol Sci. 2015;16:12076–91.CrossRefGoogle Scholar
  6. 6.
    Chang YH, Liu HW, Wu KC, Ding DC. Mesenchymal stem cells and their clinical applications in osteoarthritis. Cell Transplant. 2016;25:937.CrossRefGoogle Scholar
  7. 7.
    Sato M, Uchida K, Nakajima H, Miyazaki T, Guerrero AR, Watanabe S, Roberts S, Baba H. Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis. Arthritis Res Ther. 2012;14(1):R31.CrossRefGoogle Scholar
  8. 8.
    Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014;32(5):1254–66.CrossRefGoogle Scholar
  9. 9.
    Kølle SF, Fischer-Nielsen A, Mathiasen AB, Elberg JJ, Oliveri RS, Glovinski PV, Kastrup J, Kirchhoff M, Rasmussen BS, Talman ML, Thomsen C, Dickmeiss E, Drzewiecki KT. Enrichment of autologous fat grafts with ex-vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet. 2013;382(9898):1113–20.CrossRefGoogle Scholar
  10. 10.
    Trojahn Kolle SF, Oliveri RS, Glovinski PV, et al. Pooled human platelet lysate versus fetal bovine serum—investigating the proliferation rate, chromosome stability and angiogenic potential of human adipose tissue-derived stem cells intended for clinical use. Cytotherapy. 2013;15:1086.CrossRefGoogle Scholar
  11. 11.
    Chang H, Park JH, Min KH, Lee RS, Kim EK. Whitening effects of adipose-derived stem cells: a preliminary in vivo study. Aesthet Plast Surg. 2014;38(1):230–3.CrossRefGoogle Scholar
  12. 12.
    Kim WS, Park SH, Ahn SJ, Kim HK, Park JS, Lee GY, Kim KJ, Whang KK, Kang SH, Park BS, Sung JH. Whitening effect of adipose-derived stem cells: a critical role of TGF-beta 1. Biol Pharm Bull. 2008;31(4):606–10.CrossRefGoogle Scholar
  13. 13.
    Solano F, Briganti S, Picardo M, Ghanem G. Pigment Cell Res. 2006;19:550–71.CrossRefGoogle Scholar
  14. 14.
    Won C. Hair growth promoting effects of adipose tissue-derived stem cells. J Dermatol Sci. 2010;57:132–46.CrossRefGoogle Scholar
  15. 15.
    Shin H, Ryu HH, Kwon O, Park BS, Jo SJ. Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study. Int J Dermatol. 2015;54(6):730–5.CrossRefGoogle Scholar
  16. 16.
    Fukuoka H, Suga H. Hair regeneration treatment using adipose-derived stem cell conditioned medium: follow-up with trichograms. Eplasty. 2015;15:e10.PubMedPubMedCentralGoogle Scholar
  17. 17.
    Strioga M, Viswanathan S, Darinskas A, Slaby O, Michalek J. Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells. Stem Cells Dev. 2012;21:2724–52.CrossRefGoogle Scholar
  18. 18.
    Tremolada C, Palmieri G, Ricordi C. Adipocyte transplantation and stem cells: plastic surgery meets regenerative medicine. Cell Transplant. 2010;19(10):1217–23.CrossRefGoogle Scholar
  19. 19.
    Wang W, Fang XH, Williams SJ, et al. Lidocaine-induced ASC apoptosis (tumescent v. local anesthesia). Aesthet Plast Surg. 2014;38:1017–23.CrossRefGoogle Scholar
  20. 20.
    Goldman JJ, Wang WZ, Fang XH, Williams SJ, Baynosa RC. Tumescent liposuction without lidocaine. Plast Reconstr Surg Glob Open. 2016;4(8):e829.CrossRefGoogle Scholar
  21. 21.
    Bowen JE. Technical issues in harvesting and concentrating stem cells (bone marrow and adipose). PM R. 2015;7:S8–S18.CrossRefGoogle Scholar
  22. 22.
    Vincent L, Chen W, Hong L. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: contribution to its anti-angiogenic effect. FEBS Lett. 2001;495:159–66.CrossRefGoogle Scholar
  23. 23.
    Raposio E, Caruana G, Bonomini S, Libondi G. A novel and effective strategy for the isolation of adipose-derived stem cells: minimally manipulated adipose-derived stem cells for more rapid and safe stem cell therapy. Plast Reconstr Surg. 2014;133(6):1406–9.PubMedGoogle Scholar
  24. 24.
    Trivisonno A, Di Rocco G, Cannistra C, Finocchi V, Torres Farr S, Monti M, Toietta G. Harvest of superficial layers of fat with a microcannula and isolation of adipose tissue-derived stromal and vascular cells. Aesthet Surg J. 2014;34(4):601–13.CrossRefGoogle Scholar
  25. 25.
    Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg. 2013;132(4):1017–26. Scholar
  26. 26.
    Danilenko DM, Ring BD, Pierce GF. Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy. Mol Med Today. 1996;2:460–7.CrossRefGoogle Scholar
  27. 27.
    De Ugarte DA, Alfonso Z, Zuk PA, Elbarbary A, Zhu M, Ashjian P, Benhaim P, Hedrick MH, Fraser JK. Differential expression of stem cell mobilization-associated molecules on multilineage cells from adipose tissue and bone marrow. Immunol Lett. 2003;89(2-3):267–70.CrossRefGoogle Scholar
  28. 28.
    De Ugarte DA, Morizono K, Elbarbary A, Alfonso Z, Zuk PA, Zhu M, Dragoo JL, Ashjian P, Thomas B, Benhaim P, Chen I, Fraser J, Hedrick MH. Comparison of multilineage cells from human adipose tissue and bone marrow. Cells Tissues Organs. 2003;174(3):101–9.CrossRefGoogle Scholar
  29. 29.
    Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis. Arch Intern Med. 1999;159:941–55.CrossRefGoogle Scholar
  30. 30.
    Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7:211–28.CrossRefGoogle Scholar
  31. 31.
    Goisis M. A novel closed system for isolating stem cells. Face congress, London, 2017.Google Scholar
  32. 32.
    Mahdavian Delavary B, van der Veer WM, van Egmond M, Niessen FB, Beelen RH. Macrophages in skin injury and repair. Immunobiology. 2011;216:753–62.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Mario Goisis
    • 1
  • Ribó Planas
    • 2
  • Muñoz del Olmo
    • 2
  • Sara Izzo
    • 3
  • Andrea Sbarbati
    • 4
  • Giamaica Conti
    • 4
  1. 1.Maxillo-Facial and Aesthetic SurgeonGo Easy ClinicMilanItaly
  2. 2.Clínica PlanasBarcelonaSpain
  3. 3.Department of Plastic Surgery, University of Campania “Luigi Vanvitelli”, NaplesNaplesItaly
  4. 4.Department of Neuroscience, Biomedicine and Movement, Human Anatomy and Histology Section, University of VeronaVeronaItaly

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