Advanced Regenerative Strategies for Human Knee Meniscus

  • Ibrahim Fatih Cengiz
  • Joana Silva-Correia
  • Helder Pereira
  • João Espregueira-Mendes
  • Joaquim Miguel Oliveira
  • Rui Luís Reis
Chapter
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 21)

Abstract

The meniscus tissue has important roles in the function and biomechanics of the knee. Despite the great advances in the treatment of meniscus lesions, the clinical need is still not fulfilled. To overcome the challenges of regeneration, tissue engineering-based strategies have been attempted with limited success. The process of meniscus tissue regeneration is very complex and has many parameters that are evident only to a certain degree. Today, the regenerative strategies have been advancing beyond the traditional tissue engineering concept by growing the utilization of the expertises of complementary areas that include, but not limited to, bioreactor engineering, bioprinting coupled to reverse engineering, biology, nanotechnology and gene therapy approaches. Herein, the recent reported advanced strategies involving bioreactors, self-assembling process, and somatic gene therapy for meniscus regeneration are overviewed.

Notes

Acknowledgments

The authors thank to the financial support of the MultiScaleHuman project (Contract number: MRTN-CT-2011-289897) in the Marie Curie Actions—Initial Training Networks. I. F. Cengiz thanks the Portuguese Foundation for Science and Technology (FCT) for the Ph.D. scholarship (SFRH/BD/99555/2014). J. M. Oliveira also thanks to the FCT for the funds provided to under the program Investigador FCT 2012 (IF/00423/2012).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Ibrahim Fatih Cengiz
    • 1
    • 2
  • Joana Silva-Correia
    • 1
    • 2
  • Helder Pereira
    • 1
    • 2
    • 3
    • 4
  • João Espregueira-Mendes
    • 2
    • 3
  • Joaquim Miguel Oliveira
    • 1
    • 2
  • Rui Luís Reis
    • 1
    • 2
  1. 1.3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarco GMRPortugal
  2. 2.ICVS/3B’s—PT Government Associate LaboratoryBraga/GuimarãesPortugal
  3. 3.Clínica Espregueira-Mendes F.C. Porto Stadium—FIFA Medical Centre of ExcellencePortoPortugal
  4. 4.Orthopedic DepartmentCentro Hospitalar Póvoa de VarzimVila do CondePortugal

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